Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1-Dependent Regulation of MAD2L1 mRNA Stability.

Patients diagnosed with soft tissue sarcoma (STS) often present at intermediate to advanced stages, with inherently limited therapeutic options available. There is an urgent need to identify novel therapeutic targets. In this study, by screening STS data from the Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) databases, KIFC1 is identified as a potential biomarker and a promising therapeutic target for STS.

A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV.

Epstein-Barr virus (EBV) is a global public health concern, as it is known to cause multiple diseases while also being etiologically associated with a wide range of epithelial and lymphoid malignancies. Currently, there is no available prophylactic vaccine against EBV. gB is the EBV fusion protein that mediates viral membrane fusion and participates in host recognition, making it critical for EBV infection in both B cells and epithelial cells.

Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade.

Purpose: Radiation-induced sarcomas (RIS) have a poor prognosis and lack effective treatments. Its genome and tumor microenvironment are not well characterized and need further exploration.

Experimental Design: Here, we performed whole-exome sequencing (WES) and mRNA sequencing (mRNA-seq) on patients with RIS and primary sarcomas (WES samples 46 vs.

A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice.

Antibiotic-associated diarrhea (AAD) is a common side-effect of antibiotic treatment resulting from an imbalance in the colonic bacteria. The hypothesis of this study is to ask whether polysaccharide from the rhizome of Dioscorea opposita which is recorded as conventional herbs and food for diarrhea treatment in Southeast Asia, may be an active compound against diarrhea induced by antibiotics. To address, firstly, a homogenous polysaccharide, DOP0.

The Impact of Unplanned Excision on the Outcomes of Patients With Soft Tissue Sarcoma of the Trunk and Extremity: A Propensity Score Matching Analysis.

Background: Unplanned excision (UPE) of soft tissue sarcoma (STS) is often chosen in the early phase by general physicians without any radiological evaluation.

Purpose: The present study aimed to evaluate the impact of UPE on the clinical outcomes of patients with STS of the trunk and extremity.

Materials And Methods: Patients with STS of the trunk and extremity who underwent R0 resection between 1998 and 2016 were included and divided into the UPE and planned excision (PE) groups.

[High Throughput Screening Analysis of Preservatives and Sweeteners in Carbonated Beverages Based on Improved Standard Addition Method].

Simulated water samples of 3 kinds of preservatives and 4 kinds of sweeteners were formulated by using orthogonal design. Kernel independent component analysis (KICA) was used to process the UV spectra of the simulated water samples and the beverages added different amounts of the additive standards, then the independent components (ICs), i. e.

[Determination and comparison of metal elements in Huai radix rehmanniae at different grades by ICP-MS].

The Huai radix rehmanniae at different grades was pretreated by wet digestion, and then the metal elements in the radix rehmanniae and the prepared sample by steaming method were determined using ICP-MS. The results indicate that there is no obvious difference in the metal elements between the different grades and between the dried radix rehmanniae and its corresponding prepared product. There are elements Zn, Cu, Cr, Fe, Mn, Sn, Ni, Mo, Go, etc.

From 1D zigzag chain to 1D tubular structure, weak field ligand-dependent assembly of cucurbit[6]uril-based tubular coordination polymer.

The reaction of cucurbit[6]uril with Cu(NO3)2 and CuCl2, respectively, generates a 1D zigzag chain of {[Cu(H2O)4(cucurbit[6]uril)].(NO3)2.(H2O)8}n and a 1D tubular structure of {[Cu(H2O)2(Cl)2(cucurbit[6]uril)](1/3).

[Joint inhibition of benzene and monosubstituted benzenes on ammonia-oxidizing activity of sediment].

The joint inhibitions of benzene and three kinds of monosubstituted benzenes (aniline, phenol and nitrobenzene) on ammonia-oxidizing activity of sediment was investigated in order to study the effects of combined pollutants on nitrification process in the nitrogen cycle. The results showed that the joint inhibiton of 11 different kinds of mixtures, including binary or multi-equitoxic mixtures among benzene, aniline, phenol and nitrobenzene, exhibited different effects on ammonia-oxidizing activity of sediment, among which seven were addictive effect, three were synergistic, and only the mixture of benzene and phenol was antagonism. A conclusion could be made that the addition of nitrobenze to a mixture usually exhibited addictive effect.

[Inhibition of aromatics on ammonia-oxidizing activity of sediment].

The inhibition of 24 aromatics on ammonia-oxidizing activity of nitrifying bacteria in sediment was measured. The effects of the kind, number and position of substituted groups on ammonia-oxidizing activity of nitrifying bacteria were discussed. The inhibition of mono-substituted benzenes on ammonia-oxidizing activity of nitrifying bacteria were in order of -OH > -NO2 > -NH2 > -Cl > -CH3 > -H.