Temporal multilayer structures in discrete physical systems towards arbitrary-dimensional non-Abelian Aharonov-Bohm interferences.

Temporal modulation recently draws great attentions in wave manipulations, with which one can introduce the concept of temporal multilayer structure, a temporal counterpart of spatially multilayer configurations. This kind of multilayer structure holds temporal interfaces in the time domain, which provides additional flexibility in temporal operations. Here we take this opportunity and propose to simulate a non-Abelian gauge field with a temporal multilayer structure in the discrete physical system.

Pressure-Induced Re-Entrant Superconductivity in Transition Metal Dichalcogenide TiSe.

Transition metal dichalcogenide TiSe exhibits a superconducting dome within a low pressure range of 2-4 GPa, which peaks with the maximal transition temperature T of ≈1.8 K. Here it is reported that applying high pressure induces a new superconducting state in TiSe, which starts at ≈16 GPa with a substantially higher T that reaches 5.

MiR-221-5p regulates blood-brain barrier dysfunction through the angiopoietin-1/-2/Tie-2 signaling axis after subarachnoid hemorrhage.

Aim: To explore the potential role of microRNA miR-221-5p on the angiopoietin-1 (Ang-1)/Ang-2/Tie-2 signaling axis after subarachnoid hemorrhage (SAH) in a rat model.

Methods: Aspects of the rat's behavior were measured using the Kaoutzanis scoring system to test neurological responses. This included feeding behavior, body contraction, motor, and eye-opening responses.

[Application of analgesia and sedation under BIS monitoring combined with hydraulic coupling intracranial pressure monitoring in severe craniocerebral injury].

Objective: To investigate the clinical value of analgesia and sedation under bispectral index (BIS) monitoring combined with hydraulic coupled intracranial pressure (ICP) monitoring in severe craniocerebral injury (sTBI).

Methods: (1) A prospective self-controlled parallel control study was conducted. A total of 32 patients with sTBI after craniotomy admitted to the intensive care unit (ICU) of the First People's Hospital of Huzhou from December 2020 to July 2021 were selected as the research objects.

Effects of Ion Irradiation and Temperature on Mechanical Properties of GaN Single Crystals under Nanoindentation.

Understanding the impact of irradiation and temperature on the mechanical properties of GaN single crystals holds significant relevance for rational designs and applications of GaN-based transistors, lasers, and sensors. This study systematically investigates the influence of C-ion irradiation and temperature on pop-in events, hardness, Young's modulus, and fracture behavior of GaN single crystals through nanoindentation experiments. In comparison with unirradiated GaN samples, the pop-in phenomenon for ion-irradiated GaN samples is associated with a larger critical indentation load, which decreases with increasing temperature.

Clinical characteristics and prognostic risk factors of candidemia in non-neutropenic patients: a retrospective cohort study.

This study aimed to determine the clinical characteristics and the prognostic risk factors in non-neutropenic patients with candidemia. Data were retrospectively collected through the medical record information system. Non-neutropenic patients with candidemia were relatively aged, with a more than one-third rate of in-hospitalization mortality.

STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.

Background: Striatin interacting protein 2 (STRIP2) is a core component of the striatin-interacting phosphatase and kinase (STRIPAK) complexes, which is involved in tumor initiation and progression via the regulation of cell contractile and metastasis. However, the underlying molecular mechanisms of STRIP2 in non-small cell lung cancer (NSCLC) progression remain largely unknown.

Methods: The expressions of STRIP2 and IGF2BP3 in human NSCLC specimens and NSCLC cell lines were detected using quantitative RT-PCR, western blotting, and immunohistochemistry (IHC) analyses.

Spacer-Dependent and Pressure-Tuned Structures and Optoelectronic Properties of 2D Hybrid Halide Perovskites.

Compared with their 3D counterparts, 2D hybrid organic-inorganic halide perovskites (HOIPs) exhibit enhanced chemical stabilities and superior optoelectronic properties, which can be further tuned by the application of external pressure. Here, we report the first high-pressure study on CMAPbI (CMA = cylcohexanemethylammonium), a 2D HOIP with a soft organic spacer cation containing a flexible cyclohexyl ring, using UV-visible absorption, photoluminescence (PL) and vibrational spectroscopy, and synchrotron X-ray microdiffraction, all aided with density functional theory (DFT) calculations. Substantial anisotropic compression behavior is observed, as characterized by unprecedented negative linear compressibility along the axis.

Incidence, clinical characteristics, risk factors and outcomes of patients with mixed Candida/bacterial bloodstream infections: a retrospective study.

Purpose: The mixed Candida/bacterial bloodstream infections (mixed C/B-BSIs) is worthy of particular attention recently, and we analyzed the incidence, co-pathogens, clinical characteristics, risk factors, and outcomes of mixed C/B-BSIs compared with monomicrobial candidemia (mono-candidemia) in adult patients in China.

Methods: All hospitalized adults with candidemia were recruited for this retrospective observational study from January 1, 2013, to December 31, 2019.

Results: Of the 296 patients with candidemia, 78 cases (26.

PPDPF promotes lung adenocarcinoma progression via inhibiting apoptosis and NK cell-mediated cytotoxicity through STAT3.

Lung cancer is the most common malignancy and the leading cause of cancer death worldwide, and lung adenocarcinoma (LUAD) is the most prevalent subtype. Considering the emergence of resistance to therapies, it is urgent to develop more effective therapies to improve the prognosis. Here we reported that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) deficiency inhibited LUAD development both in vitro and in vivo.

Mechanical Properties of GaN Single Crystals upon C Ion Irradiation: Nanoindentation Analysis.

Mechanical properties of gallium nitride (GaN) single crystals upon carbon ion irradiation are examined using nanoindentation analysis at room temperature. Pop-in events in the load-depth curves are observed for unirradiated and irradiated GaN samples. A statistical linear relationship between the critical indentation load for the occurrence of the pop-in event and the associated displacement jump is exhibited.

Clinical Features, Strain Distribution, Antifungal Resistance and Prognosis of Patients with Non Candidemia: A Retrospective Observational Study.

Purpose: () candidemia has been well reported in previous studies, while research on non (NAC) bloodstream infections remains poorly explored. Therefore, the present study aimed to investigate the clinical characteristics and outcomes of patients with NAC candidemia.

Patients And Methods: We recruited inpatients with candidemia from January 2013 to June 2020 in a tertiary hospital for this retrospective observational study.

Stabilizing LiNi Co Mn O Cathode by Doping Sulfate for Lithium-Ion Batteries.

Residual sulfate (SO ) in precursor Ni Co Mn (OH) (pre-NCM) is commonly regarded as being harmful to Li[Ni Co Mn ]O (NCM) performance, leading to significant performance losses and also hampering the electrode fabrication. Therefore, manufacturers try their best to lower sulfate contents in pre-NCM. However, how the sulfate affects the cathode materials is not systematically studied.

Therapeutic efficacy of chitosan nanoparticles loaded with BCG-polysaccharide nucleic acid and ovalbumin on airway inflammation in asthmatic mice.

In this study, immunoregulation and desensitization therapies were jointly applied in the treatment of asthma, in which chitosan (CS) nanoparticles were used. BALB/c mice were selected and mouse models of asthma were constructed. Mice were divided into 7 groups.

Analysis of Adherence to Antihypertensive Drugs in Chinese Patients with Hypertension: A Retrospective Analysis Using the China Health Insurance Association Database.

Objective: To analyze the adherence to antihypertensive drugs in Chinese patients with hypertension and the factors associated with the drug adherence.

Methods: The data for this analysis were obtained from the 2014 China Health Insurance Association (CHIRA) database. The study included 64,576 patients aged ≥18 years who were prescribed one of the seven antihypertensive drugs included in the study in their first prescription in 2014 and were observed for ≥180 days.

Comparative study on the pressure-induced phase transformation of anatase TiO hollow and solid microspheres.

Nanostructured anatase TiO undergoes pressure-induced phase transformation, and the transformation sequence is significantly different from the bulk counterpart. The size and the morphology are found both playing a critical role in the phase transformation behavior. In this work, we prepare anatase TiO microspheres using a hydrothermal method.

LiF Splitting Catalyzed by Dual Metal Nanodomains for an Efficient Fluoride Conversion Cathode.

The critical challenges for fluoride conversion cathodes lie in the absence of built-in Li source, poor capacity retention, and rate performance. For lithiated fluorides, the reason to limit their competitiveness is rooted in the facile coarsing of insulating LiF (as built-in Li source) and its insufficient splitting kinetics during charging. Previous efforts on blending LiF nanodomains with reductive metal, metal oxide, or fluoride by ball-milling method still face the problems of large overpotential and low current density.

Identification of tumor-educated platelet biomarkers of non-small-cell lung cancer.

Background: Lung cancer is a severe cancer with a high death rate. The 5-year survival rate for stage III lung cancer is much lower than stage I. Early detection and intervention of lung cancer patients can significantly increase their survival time.

EGFR may participate in immune evasion through regulation of B7‑H5 expression in non‑small cell lung carcinoma.

Lung cancer is one of the most prevalent malignancies worldwide; it has been ranked the most lethal type of cancer. Non‑small cell lung carcinoma (NSCLC) comprises >80% of all types of lung cancer. Although certain achievements have been made in the treatment of NSCLC, including the targeted gene drug epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), the five‑year survival rate of patients has not significantly increased.

Evaluation of Preprocedural Laboratory Parameters as Predictors of Drug-Eluting Stent Restenosis in Coronary Chronic Total Occlusion Lesions.

This retrospective, single-center study assessed the prognostic value of several emerging inflammatory markers as predictors of in-stent restenosis (ISR) after drug-eluting stent implantation for coronary chronic total occlusion (CTO) lesions. Consecutive patients (n = 416) who underwent successful percutaneous coronary intervention (PCI) for documented CTO lesions and with follow-up angiography were enrolled. Preprocedural high-sensitivity C-reactive protein (hsCRP), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) were analyzed.

Temperature-dependent thermal properties of Ru/C multilayers.

Multilayers made of Ru/C are the most promising candidates when working in the energy region 8-20 keV. The stability of its thermal properties, including thermal expansion and thermal conduction, needs to be considered for monochromator or focusing components. Ru/C multilayers with periodic thicknesses of 3, 4 and 5 nm were investigated in situ by grazing-incidence X-ray reflectometry and diffuse scattering in order to study their thermal expansion characteristics as a function of annealing temperature up to 400°C.

Correlation between nitric oxide content in exhaled breath condensate and the severity of acute respiratory distress syndrome.

Nitric oxide (NO) can induce necrosis and detachment of branchial epithelium, aggregate inflammation and induce acute respiratory distress syndrome (ARDS). The detection of NO in exhaled breath condensate (EBC) has not been widely applied in evaluating ARDS condition. This study thus tested NO in EBC of ARDS patients, in order to provide non-invasive method to monitor disease condition of ARDS.