Risk factors for mediastinal lymph node metastases in early-stage non-small-cell lung cancer and prediction model establishment.

This study aimed to explore the risk factors for mediastinal lymph node metastases (MLNM) in patients with early-stage non-small-cell lung cancer (NSCLC) and to establish a predictive model. A retrospective analysis was conducted on the clinical data from NSCLC patients treated at the Second Affiliated Hospital of Guangzhou Medical University and the First Affiliated Dongguan Hospital of Guangdong Medical University between March 2021 and March 2023. Baseline clinical data, laboratory parameters, and pathological features were collected and analyzed.

Large-Scale Mapping of Maize Plant Density Using Multi-Temporal Optical and Radar Data: Models, Potential and Application Strategy.

Accurate crop density estimation is critical for effective agricultural resource management, yet existing methods face challenges due to data acquisition difficulties and low model usability caused by inconsistencies between optical and radar imagery. This study presents a novel approach to maize density estimation by integrating optical and radar data, addressing these challenges with a unique mapping strategy. The strategy combines available data selection, key feature extraction, and optimization to improve accuracy across diverse growth stages.

Exosome-Mediated Lectin Pathway and Resistin-MIF-AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia.

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet levels and heightened susceptibility to bleeding resulting from augmented autologous platelet destruction and diminished thrombopoiesis. Although antibody-mediated autoimmune reactions are widely recognized as primary factors, the precise etiological agents that trigger ITP remain unidentified. The pathogenesis of ITP remains unclear owing to the absence of comprehensive high-throughput data, except for the belated emergence of autoreactive antibodies.

Early differentiation of committed erythroid cells defined by miR-144/451 expression.

Before committing to an erythroid cell lineage, hematopoietic stem cells differentiate along a myeloid cell pathway to generate megakaryocyte-erythroid biopotential progenitor cells in bone marrow. Recent studies suggest that erythroid progenitors (EryPs) could be generated at the level of common myeloid progenitors (CMPs). However, due to a lack of suitable markers, little is known about the early differentiation of these committed EryP cells during CMP development.

Study protocol: A national cross-sectional study on psychology and behavior investigation of Chinese residents in 2023.

Introduction: This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

Interventional surgery shows efficacy for diabetic patients withperipheral vascular disease.

Objective: To analyze the effect of interventional surgery on treatment efficacy and inflammatory cytokine (ICK) levels in diabetic patients with peripheral vascular disease (PVD).

Methods: A total of 116 diabetic patients with PVD admitted to the Second Affiliated Hospital of Guangzhou Medical University from August 2020 to March 2022 were selected for this retrospective analysis. Patients were divided into two groups: 58 patients receiving conventional medication were assigned to the control group, while 58 patients receiving interventional surgery in addition to conventional medication were assigned to the research group.

Construction of a lung cancer 3D culture model based on alginate/gelatin micro-beads for drug evaluation.

Background: Lung cancer is one of the most common malignant tumors worldwide. Despite advances in lung cancer treatment, patients still face challenges related to drug resistance and recurrence. Current methods for evaluating anti-cancer drug activity are insufficient, as they rely on two-dimensional (2D) cell culture and animal models.

Main Coronary Flow Calculation With the Assistance of Physiological Side Branch Flow.

Objective: Fractional flow reserve (FFR) derived from coronary angiography, referred to as ICA-FFR, is a less-invasive alternative for invasive FFR measurement based on computational fluid dynamics. Blood flow into side branches influences the accuracy of ICA-FFR. However, properly compensating for side branch flow in ICAFFR analysis is challenging.

Structure-activity relationship study of Pseudellone C as anti-glioma agents by targeting TNF/TNFR signaling pathway.

Glioma, a common primary brain tumor, is highly infiltrative and invasive, often leading to drug resistance and recurrence. Therefore, the development of novel therapeutic agents is urgently needed. Pseudellone C is a novel marine triindole alkaloid.

Dysregulated T-cell homeostasis and decreased CD30 Treg proliferating in aplastic anemia.

Aplastic anemia (AA) is an autoimmune hematopoietic disease mediated by autoreactive T cells leading to bone marrow failure. However, the precise role of autoreactive T cells in the development of AA is not fully understood, hindering the advancement of therapeutic and diagnostic strategies. In this study, we conducted a single-cell transcriptome analysis of CD8 T cells, conventional CD4 T (CD4 Tconv) cells, and Treg cells, to elucidate the potential disruption of T cell homeostasis in patients with AA.

Successful Retrograde Percutaneous Coronary Intervention for Chronic Total Occlusion in a Patient with Dextrocardia.

Dextrocardia is a very rare congenital malposition, and most cardiologists are not familiar with the radiographic angiograms of this condition. Here, we first report a case of dextrocardia with a chronic total occlusion (CTO) lesion undergoing retrograde percutaneous coronary intervention (PCI). Significant difficulties in lesion interpretation and device manipulation were encountered with the original angiograms.

The denitrification characteristics of NaSO solution in a falling film reactor.

Wet scrubbing technology is an effective emission control technology for marine diesel engines. Nitric oxide (NO) is one of the main component of ship emissions, the sodium persulfate (NaSO) can facilitate the NO mass transfer process to a rapid reaction. Falling film reactors are widely used in rapid gas-liquid reactions, however, the reaction characteristics of denitrification using NaSO solution in a falling film reactor are not clear, which were investigated in this paper.

Pilot-Scale Experimental Study on the Coupling of Venturi-Bubbling Reactor to Promote the Absorption of Leaked HS.

Natural gas generates varying concentrations of HS during natural formation and extraction, and HS leak accidents are frequent, posing a significant threat to the safety of human life and the environment. Conventional treatment technology equipment is large and does not meet the emergency requirements of the complex topographical gas field. This study aimed to design a pilot-scale method coupling the venturi and bubbling reactors to reduce equipment size and improve emergency capabilities for the absorption of leaked HS.

Understanding the mechanism of safety attitude mitigates the turnover intention novice nurses via the person-centred method: A theory-driven, deductive cross-sectional study.

Aim: Examine profiles of safety attitudes among novices and explore whether profiles moderate the occupational identity-turnover pathway.

Background: Novice nurses face unique challenges in adopting positive safety attitudes, which influence outcomes like turnover. However, past research found only average levels of safety attitudes among novices, ignoring possible heterogeneity.

Small-molecule α-lipoic acid targets ELK1 to balance human neutrophil and erythrocyte differentiation.

Background: Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid and myeloid differentiation might help to find new target for therapy of myeloid leukemia.

High-Loading Smart Carrier Containing 2-Mercaptobenzimidazole-Zn-Polydopamine with pH-Responsive Function to Fabricate High-Performance Waterborne Epoxy Anticorrosion Coatings.

Corrosion inhibitor additives are considered to be one of the effective methods to slow down the corrosion of metals, but the corrosion inhibitors will decompose and lose their effect in a long-term corrosive environment. In this work, a smart corrosion inhibitor carrier 2-mercaptobenzimidazole-Zn-polydopamine@graphite (MZPG) with excellent pH response was designed and synthesized using a one-pot method. This corrosion inhibitor carrier not only has a very high 2-mercaptobenzimidazole (MBI) loading capacity (38.

Structural elucidation and anti-psoriasis activity of a novel polysaccharide from Saussurea Costus.

PSCP, a novel water-soluble polysaccharide, was extracted from the root of Saussurea costus and subsequently purified using DEAE-52 cellulose and Sephadax G-50 columns. The elucidation of its structure involved various techniques including HPGPC, FT-IR, HPLC-ELSD, GC-MS, NMR, AFM, and SEM. The results show that PSCP was a homogeneous heteropoly saccharide having molecular weight of 4131 Da and mainly composed of 1-α-D-Glcp-(-2-β-D-Fruf-1-)-2-β-D-Fruf.

Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells.

Background: Mesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic stem/progenitor cells (HSPCs). MSCs derived from human pluripotent stem cells represent an ideal alternative because of their unlimited supply. However, the role of MSCs with neural crest origin derived from HPSCs on the maintenance of HSPCs has not been reported.

Short time effects of two radiofrequency ablation methods on hypertrophic obstructive cardiomyopathy.

Background: Radiofrequency ablation has been applied for the treatment of hypertrophic obstructive cardiomyopathy (HOCM). The two known procedures are percutaneous intramyocardial septal radiofrequency ablation (PIMSRA) and endocardial radiofrequency septal ablation (ERSA).

Methods: This study presents a retrospective analysis of the PIMSRA and ERSA procedures in patients with drug-refractory HOCM.

Transcription factor Hoxb5 reveals the unidirectional hierarchy of hematopoietic stem cell pool.

Hoxb5 exhibits preferential expression in hematopoietic stem cells (HSCs) and uniquely marks the long-term HSCs (LT-HSCs). Previous studies have demonstrated the remarkable capability of Hoxb5 to alter cell fates when enforced expression in blood progenitors, such as B cell progenitors and multipotent progenitors. Additionally, Hoxb5 deficiency does not hinder the generation of LT-HSCs.

A DNA-inspired injectable adhesive hydrogel with dual nitric oxide donors to promote angiogenesis for enhanced wound healing.

Chronic diabetic wounds are a severe complication of diabetes, often leading to high treatment costs and high amputation rates. Numerous studies have revealed that nitric oxide (NO) therapy is a promising option because it favours wound revascularization. Here, base-paired injectable adhesive hydrogels (CAT) were prepared using adenine- and thymine-modified chitosan (CSA and CST).

Pioneering Enhanced Corrosion Resistance along the Normal Plane of an Ultra-Light Mg-Li Extruded Sheet.

The microstructure and corrosion anisotropy of the Mg-5Li extruded sheet were investigated in this work. Three distinct samples cut from the normal plane (A), longitudinal plane (B), and cross-sectional plane (C) of the as-extruded sheet were prepared. The microstructure was analyzed using optical microscopy (OM), scanning electron microscopy (SEM), and X-ray diffraction (XRD).

Sensory-Guided Isolation, Identification, and Active Site Calculation of Novel Umami Peptides from Ethanol Precipitation Fractions of Fermented Grain Wine (Huangjiu).

Huangjiu is rich in low-molecular-weight peptides and has an umami taste. In order for its umami peptides to be discovered, huangjiu was subjected to ultrafiltration, ethanol precipitation, and macroporous resin purification processes. The target fractions were gathered according to sensory evaluation.