Publications by authors named "Dong Yeup Lee"
Background: Programmed death-ligand 1 (PD-L1) expression is abundant not only in malignant cells but also in infiltrating cells within the tumor microenvironment (TME) of hepatocellular carcinoma (HCC). This study explored the association between PD-L1 expression in TME and outcomes in HCC patients treated with atezolizumab plus bevacizumab (AB), emphasizing the implications of PD-L1 expression in both malignant and tumor-infiltrating cells.
Methods: This study included 72 patients with HCC who underwent percutaneous core needle liver biopsy before AB treatment between September 2020 and December 2023.
Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern, and despite its high prevalence, lifestyle modifications such as exercise play a pivotal role in resolving this condition. This study aims to identify factors associated with NAFLD resolution, with a focus on the role of exercise, in different age groups.
Methods: Longitudinal data from Korean military officers, during the period 2019-2021, were obtained from the National Health Information Database.
Background/aims: Although numerous noninvasive steatosis indices have been developed to assess hepatic steatosis, whether they can be applied to young adults in the evaluation of metabolic dysfunction-associated steatotic liver disease (MASLD) remains uncertain.
Methods: Data from patients under 35 years of age who visited the Liver Health Clinic at the Armed Forces Goyang Hospital between July 2022 and January 2024 were retrospectively collected. Steatosis was diagnosed on the basis of a controlled attenuation parameter score ≥250 dB/m.
Hepatic graft-versus-host disease (GVHD) significantly impacts morbidity and mortality among allogeneic hematopoietic stem cell transplant recipients. However, the relationship between clinical and immunopathological phenotypes and their influence on clinical outcomes in hepatic GVHD is not well understood. In this study, we aimed to study the implications of portal T-cell infiltration on the clinical outcomes in hepatic GHVD and its similarities to autoimmune liver disease.
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- HCC (Hepatocellular carcinoma) is a common cancer, but the reasons for resistance to the treatment drug sorafenib are not thoroughly understood.
- A study utilized machine learning to identify that unphosphorylated interferon-stimulated genes (U-ISGs) and the U-ISGF3 complex are linked to sorafenib resistance in liver cancer cells.
- The findings suggest that targeting the U-ISGF3 complex could help overcome sorafenib resistance in patients, indicating its potential relevance for treatment strategies.