TFE3 fusion proteins promote the progression of TFE3 rearranged renal cell carcinoma via enhancing chaperone-mediated lipophagy.

Background: TFE3 rearranged renal cell carcinoma (TFE3 rRCC), classified as a distinct entity of RCCs, exhibits aggressive biological behavior and possesses unique metabolic characteristics. In the present study, TFE3 rRCC with high expression of TFE3 fusion proteins was employed to investigate the features of lipid metabolism and its underlying mechanism in cancer progression.

Methods: Fluorescence microscope and flow cytometry were employed to detect lipid droplets (LDs).

π-π Conjugated Bonds Stacking/Scattering for Switchable Lubrication in Supramolecular Hydrogel.

Existing polymer materials often lack the ability to dynamically adjust lubrication in response to external stimuli. This gap in adaptable lubrication technology limits their application in advanced systems such as intelligent motion devices and soft robotics. To address this challenge, a dual-responsive lubricating hydrogel is introduced designed with a thermal and shear-responsive supramolecular network integrated into a stable polymer framework.

An entomopathogenic strain of (hypocreales: Cordycipitaceae) against (acarina: Tetranychidae) and its compatibility with (acarina: Phytoseiidae).

is an important pest on several agricultural crops, and its resistance to pesticides has promoted the exploration of biological control strategies. and have been identified as potential agents for suppressing spider mites. This study aimed to investigate the pathogenicity of on and its compatibility with .

Induces Strong Defense and Increases Resistance in Tomato to .

Pre-stimulation of plants can change their resistance mechanisms, thereby enhancing their defense responses. , a broad-spectrum entomogenous fungi, can also induce plant defenses, but it received little attention. Here, we show that can act as a stimulus to prime tomato defense responses, improving resistance in the plant to herbivore stress.

Development of a Casting Process Database for Rapid Process Design Using Case-Based Reasoning.

Casting process design is crucial in manufacturing; however, traditional design workflows are time-consuming and seriously reliant on the experience and expertise of designers. To overcome these challenges, database technology has emerged as a promising solution to optimize the design process and enhance efficiency. However, conventional database storing process cases often lack adequate parametric information, limiting their ability to support intelligent and automated design.

Electronic Promoter Breaks the Linear Scaling Relationship: Ultra-Rapid High-Temperature Synthesis of Heterostructured CoS/SnO@C as a Bifunctional Oxygen Catalyst for Li-O Batteries.

Li-O batteries urgently needs high discharge capacity and stable cycling performance, requiring effective and reliable bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, Hovenia acerba Lindl-like heterostructure composed of cobalt sulfide and tin dioxide supported on carbon substrate (CoS/SnO@C) is prepared via CO laser irradiation technology. The half-wave potential of CoS/SnO@C for the ORR is 0.

Remote epitaxy and exfoliation of vanadium dioxide via sub-nanometer thick amorphous interlayer.

The recently emerged remote epitaxy technique, utilizing 2D materials (mostly graphene) as interlayers between the epilayer and the substrate, enables the exfoliation of crystalline nanomembranes from the substrate, expanding the range of potential device applications. However, remote epitaxy has been so far applied to a limited range of material systems, owing to the need of stringent growth conditions to avoid graphene damaging, and has therefore remained challenging for the synthesis of oxide nanomembranes. Here, we demonstrate the remote epitaxial growth of an oxide nanomembrane (vanadium dioxide, VO) with a sub-nanometer thick amorphous interlayer, which can withstand potential sputtering-induced damage and oxidation.

[Detection and Treatment for Hemolytic Transfusion Reaction in Patient with Combined Antibody Consisted of Anti-Fy and Anti-Jk].

Objective: To investigate and assess hemolytic transfusion reaction in patient with complex and combined anti-Fy and anti-Jk which so as to provide a safety blood transfusion strategy.

Methods: ABO/Rh blood grouping, antibody screening and identification, and Coombs' tests were performed by the routine serological methods include manual tube and automatic blood group analyzer with matching micro-column gel cards from Diagnostic Grifols and Jiangsu LIBO. The hospital information system and laboratory information system were used to collect dada on patients' blood routine tests, liver and kidney function, coagulation, cardiac function, and other clinical indicators before and after blood transfusion were analyzed and compared in conjunction with the patients' clinical manifestations.

Manipulating π-π Interactions between Single Molecules by Using Antenna Electrodes as Optical Tweezers.

Via conductance measurements of thousands of single-molecule junctions, we report that the π-π coupling between neighboring aromatic molecules can be manipulated by laser illumination. We reveal that this optical manipulation originates from the optical plasmonic gradient force generated inside the nanogaps, in which the gapped antenna electrodes act as optical tweezers pushing the neighboring molecules closer together. These findings offer a nondestructive approach to regulate the interaction of the molecules, deepening the understanding of the mechanism of π-π interaction, and open an avenue to manipulate the relative position of extremely small objects down to the scale of single molecules.

Plasma bile acid profile analysis by liquid chromatography-tandem mass spectrometry and its application in healthy subjects and IBD patients.

Bile acids (BAs), not only promote the absorption of fat-soluble nutrients and regulate the metabolism of multiple substances but also have a potential role as diagnostic and prognostic indicators in a variety of diseases such as cholestasis, hepatocellular carcinoma, and diabetes mellitus. Here, a rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of 50 BAs was developed and validated. Sample preparation included internal standard spiking, followed by protein precipitation, centrifugation, solvent evaporation, and reconstitution.

Gating the Rectifying Direction of Tunneling Current through Single-Molecule Junctions.

In electronic functional chips, one of the most crucial components is the field-effect transistor (FET). To meet the urgent demands for further miniaturization of electronic devices, solid-state single-molecule transistors by molecular orbital gating have been extensively reported. However, under negative bias and positive bias, achieving a distinct gating effect is extremely challenging because molecular orbital gating is independent of the bias polarity.

Synergistic growth suppression of Fusarium oxysporum MLY127 through Dimethachlon Nanoencapsulation and co-application with Bacillus velezensis MLY71.

Fusarium oxysporum is a destructive plant pathogen with robust survival mechanisms, complicating control efforts. This study aimed to develop nanoformulated fungicides, screen antagonistic bacteria, and evaluate their combined efficacy. A novel self-emulsifying nanoemulsion (DZW) was formulated using zein and benzaldehyde-modified wheat gluten (BgWG) as carriers for dimethachlon (DTN).

Band Alignment Semimetal Heterojunction-Based Ultrabroadband Photodetector for Noncontact Gesture Interaction with Low Latency.

Non-contact gesture recognition and interaction (NGRI) revolutionizes the natural user interface, fundamentally transforming human interactions with daily-use technology. Conventional NGRI systems frequently encounter obstacles such as pronounced latency and environmental disturbances, including humidity or lighting conditions, resulting in compromised system fluidity and robustness. This study highlights the utilization of silicon-based semimetal heterojunction photodetectors for precise gesture recognition and seamless human-machine interaction.

Overexpression of STX11 alleviates pulmonary fibrosis by inhibiting fibroblast activation via the PI3K/AKT/mTOR pathway.

Fibroblast activation plays an important role in the occurrence and development of idiopathic pulmonary fibrosis (IPF), which is a progressive, incurable, and fibrotic lung disease. However, the underlying mechanism of fibroblast activation in IPF remains elusive. Here, we showed that the expression levels of STX11 and SNAP25 were downregulated in the lung tissues from patients with IPF and mice with bleomycin (BLM)-induced lung fibrosis as well as in the activated fibroblasts.

Minimally Invasive Distal Gastrectomy: Evolving Surgical Techniques.

Surgical management of gastric cancer has evolved over the years. Incorporation of minimally invasive techniques has led to shorter hospital stays, reduced wound complications, and earlier return to functional activity. Nevertheless, the development of minimally invasive total gastrectomy as a repertoire in the management of proximal or diffuse gastric cancer requires significant commitment and support owing to the complexity of the procedure.

Prevalence and distribution of serological characteristics of weak ABO subgroups in the Chinese population.

Objectives: This study aimed to determine the true frequency of weak ABO subgroups and to investigate the serological characteristics of various subgroup alleles in the Chinese population.

Methods: A total of 2,945,643 blood samples were collected from January 2009 to December 2017. After initial screening and re-examination using automatic blood group analyzers, all ABO-discrepant samples were confirmed by standard serological analysis and molecular detection by DNA sequencing.

Combining APCS-MLR model to evaluate the distribution and sources of rare earth elements in a large catchment.

Rare earth elements (REEs), functioning as indicators for environmental tracking, revealing the impacts of human activities on changes in aquatic ecosystems. However, systematic research on the geochemical characteristics of REEs in large river basins remains relatively scarce. Therefore, this research investigates the geochemical properties of REEs within the Yangtze River basin, analyzing the quantity and spatial distribution of REEs in surface aquatic environments across the upstream, midstream, and downstream segments of the Yangtze River, and quantitatively assessing their sources.

Determining the evaporation and evolution of surface water in a large catchment using isotopes and multiple models.

The evolution and formation mechanisms of chemical components in surface water can reflect changes in the geological background of a basin and the extent of human interference. The Yangtze River basin is the largest water source area in China, yet its main ion sources and formation mechanisms are not fully understood. This study uses a combination of hydrochemistry, stable isotopes (δO, δD), the Craig-Gordon model, and the APCS-MLR model to quantitatively assess the water source replenishment and evaporation intensity of surface water in the Yangtze River.

Curcumin-mediated enhancement of lung barrier function in rats with high-altitude-associated acute lung injury via inhibition of inflammatory response.

Background: Exposure to a hypobaric hypoxic environment at high altitudes can lead to lung injury. In this study, we aimed to determine whether curcumin (Cur) could improve lung barrier function and protect against high-altitude-associated acute lung injury.

Methods: Two hundred healthy rats were randomly divided into standard control, high-altitude control (HC), salidroside (40 mg/kg, positive control), and Cur (200 mg/kg) groups.

Gamma-butyrobetaine hydroxylase (BBOX1) exerts suppressive effects on HepG2 hepatoblastoma cells.

Gamma-butyrobetaine hydroxylase (BBOX1) plays a pivotal role in catalyzing the final stage of L-carnitine biosynthesis. Recently, increasing number of studies have reported that BBOX1 is weakly expressed in tumor cells and exhibits antitumor activity. The role of BBOX1 in Hepatoblastoma (HB) has yet to be determined.

The complete genome sequence of a strain MLY93 isolated from spot disease-infected tobacco leaves in China.

This study presents the complete gene sequence of a strain isolated from tobacco spot disease leaves in Xingyi, Guizhou Province, China. The genetic understanding of is advanced by this research.

Giant Hall Switching by Surface-State-Mediated Spin-Orbit Torque in a Hard Ferromagnetic Topological Insulator.

Topological insulators (TI) and magnetic topological insulators (MTI) can apply highly efficient spin-orbit torque (SOT) and manipulate the magnetization with their unique topological surface states (TSS) with ultrahigh efficiency. Here, efficient SOT switching of a hard MTI, V-doped (Bi,Sb)Te (VBST), with a large coercive field that can prevent the influence of an external magnetic field, is demonstrated. A giant switched anomalous Hall resistance of 9.