Publications by authors named "Dong Won Park"
Introduction: The provision of treatment for epidermal growth factor receptor (EGFR)-mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and treatment outcomes, using a large-scale dataset, have not been conducted. The current study is a prospective and retrospective multicenter observational cohort study that registers all stages of EGFR-mutated NSCLC patients.
View Article and Find Full Text PDFIntroduction: Guideline-discordant low-dose computed tomography (LDCT) screening may cause lung cancer (LC) overdiagnosis, but its extent and consequences are unclear. This study aimed to investigate the prevalence of self-initiated, non-reimbursed LDCT screening in a predominantly non-smoking population and its impact on LC epidemiology and healthcare utilization.
Methods: This nationwide cohort study analyzed data from Korea's National Health Information Database and 11 academic hospital screening centers (1999-2022).
The impact of pulmonary tuberculosis on SARS-CoV-2 infection: a nationwide cohort study.
Front Med (Lausanne)
September 2024
Background: The interaction between COVID-19 and tuberculosis (TB) is not yet fully understood, and large-scale research on the mortality outcome of such dual infection has been limited. This study aimed to investigate the impact of PTB on mortality among patients with COVID-19 within a Korean population by conducting an extensive analysis of a nationwide large dataset.
Method: We investigated the mortality and disease severity among COVID-19 patients who had PTB in South Korea.
Article Synopsis
- - This study investigated the relationship between chronic periodontitis (CP) and lung cancer using a large dataset from the Korean National Health Insurance Service, involving over 72,000 individuals with CP compared to matched controls without CP.
- - Results showed that individuals with CP had a significantly higher risk of developing lung cancer (2.27 times more likely) during an average follow-up of 5.1 years, with the highest risks seen in those with moderate-to-severe CP, women, and never-smokers.
- - The findings suggest that chronic periodontitis may increase lung cancer risk, highlighting the need for further research and awareness regarding oral health's impact on overall health risks.
The Impact of Bronchiectasis on the Clinical Characteristics of Non-Severe Asthma.
Allergy Asthma Immunol Res
May 2024
Current literature primarily delves into the relationship between bronchiectasis and severe asthma, and only a few studies have evaluated the impact of bronchiectasis in patients with non-severe asthma. Therefore, this study investigated the clinical impact of bronchiectasis in patients with non-severe asthma. A prospective observational study of 140 non-severe asthmatic patients with (bronchiectasis group) and without bronchiectasis (control group) was conducted between September 2012 and February 2022.
View Article and Find Full Text PDFComprehensive analyses of the association between a family history of lung cancer and lung cancer risk are limited, especially in the Korean population. We used baseline data from the Korean Genome and Epidemiology Study, conducted between 2001 and 2013. This study enrolled 198,980 individuals.
View Article and Find Full Text PDFArticle Synopsis
- Multiple isotopes, including metal isotopes, are used to identify contamination sources and pathways in groundwater, enhancing environmental forensic reliability.
- The study analyzed groundwater in a mine area, focusing on Cu, Zn, S-O, and O-H isotopes to clarify sources of contamination and geochemical processes like sulfate reduction and sulfide precipitation.
- Findings suggest that contaminated soil affects groundwater at depths less than 5 meters, while deeper groundwater shows higher contamination from adit water, with distinct isotopic signatures aiding in pinpointing contamination sources.
Article Synopsis
- The study aimed to assess the relevance of the advanced lung cancer inflammation index (ALI) as a prognostic tool for patients with limited-stage small-cell lung cancer (LS-SCLC) receiving chemo-radiotherapy.
- 87 patients were analyzed, with results showing that those in the high ALI group had better overall survival compared to the low ALI group.
- The findings indicate that a high ALI score can be used to predict better survival outcomes and may help inform treatment decisions for LS-SCLC patients.
Article Synopsis
- A study evaluated the long-term effects of recovering from COVID-19 on adults with asthma, focusing on severe exacerbations and mortality rates.
- Analyzing data from over 10,700 adults, the researchers found that those who recovered from severe COVID-19 had a significantly higher risk of severe asthma exacerbations and death compared to matched controls without COVID-19.
- The findings suggest that individuals with asthma who experienced severe COVID-19 face increased long-term health risks, while those who had a non-severe case do not show a similar risk.
Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.
Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017.
Background: Single-photon emission computed tomography/computed tomography (SPECT/CT) has the advantage of assessing regional lung function. We aimed to investigate the potential of ventilation (SPECT/CT) for predicting postoperative lung function in patients with lung cancer.
Methods: This retrospective study included consecutive patients with lung cancer who underwent lobectomy, preoperative ventilation, and perfusion SPECT/CT between January 2020 and December 2021.
Background: Adjuvant chemotherapy has reduced the risk of recurrence and death in stage IB non-small cell lung cancer (NSCLC) with high-risk factors; however, the impact of visceral pleural invasion (VPI) on outcomes in stage IB NSCLC treated with adjuvant chemotherapy remains controversial. The aim of this study was to explore the clinical and prognostic significance of adjuvant chemotherapy for stage IB (1-4 cm) NSCLC with VPI.
Methods: This retrospective study included 251 patients admitted between January 2008 and May 2018 from four hospitals who underwent complete resection for Tumor-Node-Metastasis (TNM) 8th edition stage IB NSCLC with VPI.
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility of individuals to AT-DILI and to examine genetic interactions that may lead to isoniazid (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis of 380 pharmacogenes in a discovery cohort of 112 patients (35 AT-DILI patients and 77 controls) receiving AT treatment for active tuberculosis.
View Article and Find Full Text PDFAlthough major countries, such as South Korea, have developed and disseminated national smoking cessation guidelines, these efforts have been limited to developing individual societies or specialized institution-based recommendations. Therefore, evidence-based clinical guidelines are essential for developing smoking cessation interventions and promoting effective smoking cessation treatments. This guideline targets frontline clinical practitioners involved in a smoking cessation treatment support program implemented in 2015 with the support of the National Health Insurance Service.
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- A study in Korea examined how physical activity (PA) levels affect healthcare usage, specifically emergency department visits and hospitalizations, among patients with chronic obstructive pulmonary disease (COPD).
- The research involved a large cohort of 3308 COPD patients and 293,358 non-COPD individuals, analyzing data from 2009 to 2017.
- Findings revealed that COPD patients had significantly higher risks of healthcare visits across all PA levels, especially in those who were sedentary, and increasing PA by just 500 MET-min/week could lower these risks.
Objectives: Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung disease (ILD) after COVID-19 is unclear. We aimed to determine whether COVID-19 increases the risk of newly diagnosed ILD and whether vaccination against COVID-19 can reduce this risk.
Methods: This retrospective cohort study used data from the Korean National Health Insurance claim-based database.
Background: Chronic lung diseases, such as chronic obstructive pulmonary disease or asthma, are associated with an increased risk of dementia. However, few data are available regarding the risk of dementia in individuals with bronchiectasis.
Objectives: To explore the association between bronchiectasis and the risk of incident dementia using a longitudinal population-based cohort.
Introduction: Air pollutants are increasingly recognized to affect long-term outcomes in patients with bronchiectasis. We aimed to figure out the association between air pollutants and the risk of healthcare utilization in patients with bronchiectasis.
Methods: Data for 1,029 subjects with bronchiectasis in Seoul were extracted.
Background: The association between systemic sclerosis and the development of bronchiectasis is unclear. This study aimed to compare the risk of bronchiectasis between individuals with systemic sclerosis and those without using a nationwide longitudinal dataset.
Methods: Using the Korean National Health Insurance Service dataset between 2010 and 2017, we identified 4845 individuals aged ≥ 20 years with systemic sclerosis and 24,225 without systemic sclerosis who were matched 1:5 by age and sex.