Publications by authors named "Dong Wan Shin"
Article Synopsis
- This study investigates genetic differences in drug metabolism among three East Asian populations (Korean, Japanese, and Chinese) to understand how these variations affect drug responses.
- Researchers analyzed 1936 genetic variants related to drug-processing enzymes and found that over half of the variants were the same across the groups, indicating little genetic diversity in this context.
- The findings suggest that these populations are genetically similar in terms of drug metabolism, meaning they may respond similarly to medications despite being distinct ethnic groups.
A Bayesian model-based clustering approach is proposed for identifying differentially expressed genes in meta-analysis. A Bayesian hierarchical model is used as a scientific tool for combining information from different studies, and a mixture prior is used to separate differentially expressed genes from non-differentially expressed genes. Posterior estimation of the parameters and missing observations are done by using a simple Markov chain Monte Carlo method.
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