The subcutaneous tunneled periareolar approach in lung resection performed through uniportal video-assisted thoracic surgery.

The approach for traditional uniportal video-assisted thoracoscopic surgery (Uni-VATS) is typically located on the lateral chest wall, the resulting pain and visible scars may have a negative psychological impact on patients. We present our preliminary experience with the subcutaneous tunneled periareolar approach (STPA) in lung resection performed through Uni-VATS for treating pulmonary nodules. From December 2023 through to June 2024, five patients underwent this procedure, including three cases of the wedge resection, one case of the lobectomy, and one case of the segmentectomy.

Nanophotonic Zero-Index-Material-Enabled Optical Coherent Interferometry with High Signal-to-Noise Ratio.

Optical interferometry enables distance measurement with record-high precision. However, the conventional interference intensity shows fast spatial variations, limiting photodetection to a single spot. The light intensity at this spot is affected by various noises, restricting the signal-to-noise ratio (SNR) of a coherent system.

Zanamivir alleviates ethanol intoxication through activating catalase.

Objectives: Acute alcohol intoxication is characterized as high morbidity and mortality. To explore new chemicals to relieve ethanol intoxication, we tried to explore the activators of catalase (CAT), an enzyme responsible for oxidization of ethanol into acetaldehyde to accelerate ethanol removal.

Methods: We identified zanamivir, an antiviral agent, activated CAT in vitro after screening of clinical chemicals.

Baicalein relieves lung graft ischemia-reperfusion injury by reducing advanced glycation endproducts: From screens to mechanisms.

Background: The lack of effective drugs for treating ischemia-reperfusion injury (IRI) in lung transplants (LTx) remains an issue. Traditional Chinese medicine (TCM) ingredients are promising but poorly studied in LTx. This study aimed to identify potential ingredients and elucidate their mechanisms.

Collaborative performance of enzymatic saccharification and organic pollutant degradation from PHP (phosphoric acid coupled with hydrogen peroxide) pretreatment of lignocellulose.

As a newly developed technology, lignocellulose pretreatment of PHP (phosphoric acid coupled with hydrogen peroxide) can facilitate the enzymatic hydrolysis of pretreated lignocellulose for glucose production. It also has been found that the derived oxidative tail gas from pretreatment can facilely degrade organic pollutant. To balance the pollutant degradation and the glucose yield, the collaborative optimization on pretreatment was investigated.

The swelling-induced fractionation strategy to mediate cellulose availability and lignin structural integrity.

We report a facile fractionation strategy using choline hydroxide (ChOH) based alkaline deep eutectic solvents (DES) for whole-component upgrading of bagasse. Through selective lignin and xylan dissolution, along with extensive biomass swelling, high-value lignin-carbohydrate complexes (LCC, with high β-O-4 bond content of 68.9/100 Ar) and high-purity xylan were extracted without compromising cellulose recovery and hydrolysis.

Case report: A case of giant malignant solitary fibrous tumor of the pleura with Doege-Potter's syndrome and review of the literature.

The solitary fibrous tumor of the pleura (SFTP) is a rare intrathoracic neoplasm that commonly originates from the subpleural mesenchymal cells of the visceral pleura and accounts for less than 5% of all pleural tumors. We reported a case of a 54-year-old man with a two-week history of hypoglycemia, a six-month history of productive cough and fatigue, and chronic right chest pain. Radiological techniques revealed a giant intra-thoracic mass with hypervascularization, and pathological staining was carried out to make a definitive diagnosis of SFTP.

How to select agroforestry waste biomass for electrospinning and its potential application in bone tissue engineering.

The high value-added utilization of agroforestry waste biomass is an urgent requirment. Herein, a feasible approach was provided to obtain biodegradable cellulose fibrous films from agroforestry waste biomass. The cellulose used was extracted from agroforestry waste biomass and then the cellulose fibrous film was obtained by direct electrospinning.

A novel rat lung transplantation model using venoarterial extracorporeal membrane oxygenation support.

Objectives: Extracorporeal membrane oxygenation (ECMO) has become an important life support technique during lung transplantation. We aimed to develop a rat model for lung transplantation using venoarterial (VA) ECMO support.

Methods: Adult male Sprague-Dawley rats weighing 400 to 450 g were used in this study.

Exploring the spatiotemporal trends and influencing factors of human settlement suitability in Hunan province traditional villages.

The conservation and sustainable development of traditional villages have raised global attention in the context of rapid urbanization and modernization. Taking 703 traditional villages in Hunan Province as an example, this study first constructed a Traditional Village Human Settlement Suitability (TVHSS) evaluation system based on the Pressure-State-Response (PSR) model. Then, the entropy weighting method was used to assess the spatiotemporal evolution of TVHSS from 2005 to 2020, while the Geographically Weighted Regression (GWR) model was employed to analyze the influencing factors.

How Green Space Justice in urban built-up areas affects public mental health: a moderated chain mediation model.

Background: Green and blue spaces, as crucial components of urban ecosystems, significantly impact the physical and mental health of residents. However, the mechanisms through which Green/Blue Space Justice influence residents' health remain unclear.

Methods: This study aims to explore the impact of green spaces on public psychological responses, physical activity, and mental health from a justice perspective, and to examine the moderating role of blue spaces in this relationship.

Advances and trends in the application of functional near-infrared spectroscopy for pediatric assessments: a bibliometric analysis.

Objective: The objective is to elucidate the collaboration and current research status in the pediatric field of fNIRS using bibliometric analysis, and to discuss future directions.

Method: Bibliometric analysis was conducted on publications related to pediatric fNIRS research published before June 2024 in the Web of Science Core Collection using VOSviewer software and R language.

Results: A total of 761 documents were retrieved, published by 2,686 authors from 893 institutions across 44 countries in 239 journals.

Prognostic prediction model for patients with pathological T1N0 stage esophageal squamous cell carcinoma undergone esophagectomy.

Background: There is a shortage of reliable predictive models to provide valuable prognostic information for early esophageal squamous cell carcinoma (ESCC) without lymph node metastasis (LNM). We aimed to develop and validate a nomogram using the prognostic factors in T1N0 ESCC patients.

Methods: Patients with pathological T1N0 ESCC who underwent esophagectomy between 2014 and 2021 at three institutes were reviewed.

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study.

Background: The lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as saturated fatty acids in cardiovascular diseases, including hypertension and ischemic stroke, are less frequent.

Objectives: This study aims to identify fatty acids associated with blood pressure and ischemic stroke through Mendelian randomization.

A cascaded process to upgrade bleached bamboo pulp into dissolving pulp and arabinoxylan.

The dissolving pulp preparation from bleached kraft pulp while realizing the high-value application of hemicellulose fraction is of great significance for improving the overall economics of the process. This work proposed a two-step cascaded process of deep eutectic solvent (DES) pretreatment combined with mechanical refining for the co-production of dissolving pulp and arabinoxylan (AX) from bleached bamboo pulp. Results showed that using alkaline DES composed of quaternary ammonium hydroxide and urea prepared high-quality dissolving pulp (α-cellulose content of 97.

Radiotherapy and chemoradiotherapy for postoperative recurrence in patients with esophageal squamous cell carcinoma.

Background: The optimal treatment for esophageal squamous cell carcinoma (ESCC) patients with postoperative recurrence remains controversial. We aimed to evaluate the effects of radiotherapy (RT) and chemoradiotherapy (CRT) on postoperative recurrence in ESCC patients.

Methods: Recurrence ESCC patients who received salvage RT and CRT from January 2015 to January 2019 were retrospectively reviewed.

Machine learning model predicts airway stenosis requiring clinical intervention in patients after lung transplantation: a retrospective case-controlled study.

Background: Patients with airway stenosis (AS) are associated with considerable morbidity and mortality after lung transplantation (LTx). This study aims to develop and validate machine learning (ML) models to predict AS requiring clinical intervention in patients after LTx.

Methods: Patients who underwent LTx between January 2017 and December 2019 were reviewed.

Molecular Iridium Catalyzed Electrochemical Formic Acid Oxidation: Mechanistic Insights.

Electrochemical formic acid oxidation reaction (FAOR) is a pivotal model for understanding organic fuel oxidation and advancing sustainable energy technologies. Here, we present mechanistic insights into a novel molecular-like iridium catalyst (Ir-N-C) for FAOR. Our studies reveal that isolated sites facilitate a preferential dehydrogenation pathway, circumventing catalyst poisoning and exhibiting high inherent activity.

Phaser-Trim: A Phase Separation Based Genetically Encoded Reporter for H3K9 Trimethylation in Living Cells.

Histone methylation is a key epigenetic modification that regulates the chromatin structure and gene expression for proper cellular and physiological processes. Aberrant histone methylation patterns are implicated in many diseases. Therefore, monitoring histone methylation dynamics in living cells and species is essential for elucidating its regulatory mechanisms and identifying potential therapeutic targets.

Understanding the treatment response and resistance to targeted therapies in non-small cell lung cancer: clinical insights and perspectives.

Lung cancer remains the leading cause of mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer with a generally poor prognosis. In recent years, advances in targeted therapy and sequencing technology have brought significant improvement in the therapeutic outcomes of patients with advanced NSCLC.

Lamivudine protects mice from gastric ulcer by activating PGK1 to suppress ferroptosis.

Gastric ulcer is a highly prevalent digestive tract disease across the world, which is recurrent and hard to cure, sometimes transforming into gastric cancer if left untreated, posing great threat to human health. To develop new medicines for gastric ulcer, we ran a series of screens with ethanol stress model in GES-1 cells, and we uncovered that lamivudine rescued cells from ethanol toxicity. Then, we confirmed this discovery using the well-established ethanol-induced gastric ulcer model in mice and our findings suggest that lamivudine can directly activate phosphoglycerate kinase 1 (PGK1, EC 2.

Clinical characteristics and outcomes of lung transplantation in patients with severe COVID-19 infection: A systematic review and meta-analysis.

Objectives: To synthesize the clinical experience of patients with COVID-19-associated acute respiratory distress syndrome (ARDS) or pulmonary fibrosis (PF) receiving lung transplantation (LTx) and compare the characteristics and outcomes of COVID-19 and non-COVID-19 LTx patients.

Methods: A literature search of online databases (PubMed, Web of Science, Embase, the Cochrane Library, China Science and Technology Journal Database, and Wan Fang databases) was performed regarding LTx for COVID-19-associated ARDS or PF. This study was registered on PROSPERO (CRD2024507647).

Salvage surgery and conversion surgery for patients with nonsmall cell lung cancer: a narrative review.

Nonsmall cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths. With the development of screening, patient selection, and treatment strategies, patients' survival outcomes and living quality significantly improved. However, some patients still have local recurrence or residual tumors after receiving definitive therapies.