HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function.

Unlabelled: Herpesviruses, including α-herpesvirus and herpes simplex virus (HSV-1), are masters of immune evasion. Previously we demonstrated that CD1d-restricted NKT cells are required for optimal anti-HSV-1 immune responses and HSV-1 efficiently downregulates CD1d to suppress NKT cell function. To delineate how the virus evades NKT cell function and establishes infection , we screened an HSV-1 expression library to identify the viral gene(s) downregulating CD1d and discovered that a leaky late gene, UL56, most efficiently suppresses CD1d expression by degrading the protein, apparently via both proteasome- and lysosome-dependent pathways.

A Study of the Medicinal Plants of Genus sp.: Aiming to Expand Valuable Medicinal Resources for Medical Treatment.

<b>Background and Objective:</b> <i>Orthosiphon</i> sp., contains many active ingredients that are beneficial to health. In addition to prevention, they are also used in treatment.

Sm-labeled FeO@lapatinib nanoparticles as a potential therapeutic agent for breast cancer: synthesis, quality control, and evaluation.

The present study introduces FeO-coated lapatinib-labeled Sm nanoparticles (denoted as FeO@lapatinib-Sm) as a promising avenue for advancing breast cancer treatment. The radiolabeled nanoparticles combine various attributes, offering enhanced therapeutic precision. The integration of lapatinib confers therapeutic effects and targeted delivery.

Dual anticancer and antibacterial activity of fluorescent naphthoimidazolium salts.

Cancer has emerged as a significant global health challenge, ranking as the second leading cause of death worldwide. Moreover, cancer patients frequently experience compromised immune systems, rendering them susceptible to bacterial infections. Combining anticancer and antibacterial properties in a single drug could lead to improved overall treatment outcomes and patient well-being.

Safety assessment, radioiodination and preclinical evaluation of antinuclear antibody as novel medication for prostate cancer in mouse xenograft model.

This study aims to provide in vitro and in vivo data to support the utilization of antinuclear antibodies (ANAs) as novel tools for the diagnosis and treatment of prostate cancers. The hematological, biochemical, and histological toxicities of ANAs were assessed at the doses of 5 and 50 μg per mouse. Radiolabeling study was then conducted with ANA and I using the chloramine T method, and the biodistribution and treatment efficacy were subsequently investigated in a PC3 xenograft model.

Screening for adverse childhood experiences among young people using drugs in Vietnam: related factors and clinical implications.

Background: Research evidence shows a strong association between adverse childhood experiences (ACEs) and later-life substance use. But little is known about the prevalence and impact of ACEs among young people using drugs (YPUD) in Vietnam.

Method: A cross-sectional study using respondent-driven sampling and peer recruitment methods was conducted among YPUD aged 16-24 in three cities in Vietnam.

Identifying the impact of land use land cover change on streamflow and nitrate load following modeling approach: a case study in the upstream Dong Nai River basin, Vietnam.

Tri An Reservoir is a vital source of water for agriculture, industry, hydropower, and public usage in Southern Vietnam. Due to human activities, water eutrophication has become a serious problem in recent decades. This study investigated for the first time the impact of land use and land cover (LULC) change on streamflow and nitrate load from the upstream Dong Nai River basin, which is the largest watershed of the reservoir.

COVID-19 vaccine acceptance and its determinants among Vietnamese teachers: a web-based cross-sectional survey.

Objectives: This paper aimed to describe acceptance of the COVID-19 vaccine and its determinants among Vietnamese teachers.

Methods: This was a web-based cross-sectional survey with a sample of 17,176 teachers from kindergarten to high school who currently reside in Vietnam. A participant who exhibited "acceptance" towards the vaccine gave the following response: .

Cost of postoperative sepsis in Vietnam.

Despite improvements in medical care, the burden of sepsis remains high. In this study, we evaluated the incremental cost associated with postoperative sepsis and the impact of postoperative sepsis on clinical outcomes among surgical patients in Vietnam. We used the national database that contained 1,241,893 surgical patients undergoing seven types of surgery.

Why using bed nets is a challenge among minority populations in Central Vietnam.

Background: Despite freely distributed insecticide-treated nets (ITNs) and health information campaigns to increase their use among populations at risk, malaria transmission persists in forested areas in Vietnam, especially among ethnic minority communities. A mixed-methods study was conducted in four villages of Ca Dong and M'nong ethnicity in Central Vietnam between 2009 and 2011 to assess factors limiting the uptake of ITNs.

Methods: The mixed-methods research design consisted of a qualitative study to explore the context and barriers to ITN use, and a cross-sectional household survey (n = 141) to quantify factors for limited and appropriate net use.

Comparative cellular analysis of motor cortex in human, marmoset and mouse.

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals. Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei in humans, marmoset monkeys and mice, we demonstrate a broadly conserved cellular makeup of this region, with similarities that mirror evolutionary distance and are consistent between the transcriptome and epigenome. The core conserved molecular identities of neuronal and non-neuronal cell types allow us to generate a cross-species consensus classification of cell types, and to infer conserved properties of cell types across species.

Co-Doped NdFeO Nanoparticles: Synthesis, Optical, and Magnetic Properties Study.

In this work, single-phase nanostructured NdFeCoO ( = 0, 0.1, 0.2, and 0.

Estimation of nitrogen and phosphorus concentrations from water quality surrogates using machine learning in the Tri An Reservoir, Vietnam.

Surface water eutrophication due to excessive nutrients has become a major environmental problem around the world in the past few decades. Among these nutrients, nitrogen and phosphorus are two of the most important harmful cyanobacterial bloom (HCB) drivers. A reliable prediction of these parameters, therefore, is necessary for the management of rivers, lakes, and reservoirs.

Mortality, disease and associated antimicrobial use in commercial small-scale chicken flocks in the Mekong Delta of Vietnam.

Raising chickens in small-scale flocks following all-in-all-out management is common in the Mekong Delta of Vietnam. These flocks represent an intermediate category between backyard and intensive (industrial) farming systems. However, little is known about the occurrence and burden of disease and/or mortality in such flocks, and their potential association with antimicrobial usage (AMU).

Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells.

The attachment of polyethylene glycol (PEG) increases the circulation time of drug-containing nanoparticles; however, this also negatively affects cellular uptake. To overcome this problem, unique lipid polymer hybrid (LPH) nanoparticles were developed with a pH-responsive PEG layer that detached prior to cell uptake. Docetaxel (DTX) was incorporated into the lipid core of the nanoparticles, which was then shielded with the pH-responsive block co-polymer polyethylene glycol-b-polyaspartic acid (PEG-b-PAsp) using a modified emulsion method.