Publications by authors named "Dong Soo Yu"

Purpose: The objective of this study is to evaluate the relationship of psoriasis and neovascular age-related macular degeneration (nAMD) in a population with diabetic mellitus (DM).

Design: Nationwide, population-based, retrospective cohort study.

Methods: Records of patients over 40 years of age who had been diagnosed with type 2 diabetes mellitus from January 2009 to December 2012 were analyzed.

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  • Psoriasis is a chronic skin condition influenced by genetic and environmental factors, with the scalp being a commonly affected area that is challenging to treat.
  • A study analyzed the scalp microbiomes of 11 psoriasis patients with varying severity, revealing a notable link between fungal diversity and disease severity.
  • Findings suggest that increased fungal diversity and certain microbial compositions could play a role in the severity of scalp psoriasis, indicating potential for new targeted therapies.
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  • Microcystic adnexal carcinoma (MAC) is a rare but aggressive skin cancer with a high chance of recurrence, although it rarely spreads to distant sites.
  • A 55-year-old man on immunosuppressants after liver transplantation developed a growing skin nodule, which was diagnosed as MAC after a biopsy.
  • Despite successful removal of the primary tumor, the patient returned 11 months later with new skin nodules elsewhere on his body, also confirmed to be MAC, highlighting the potential for distant spread in this rare cancer.
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Purpose: The objective of this research was to explore how psoriasis is linked to the occurrence of retinal vein occlusion (RVO) in diabetic population.

Methods: This was a retrospective, nationwide, population-based cohort study that examined medical records from January 2009 to December 2012. The study focused on patients ≥20 years of age who had been diagnosed with Type 2 diabetes mellitus (DM).

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Psoriasis is a chronic inflammatory skin disease associated with various factors. Recently, alterations in the gut and skin microbiomes have been shown to interact with host immunity, affect skin barrier function, as well as development and progression of psoriasis. We aimed to analyze the microbiota of the scalp of patients with psoriasis and determine the characteristics of the microbiome according to disease severity.

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Background: Ultraviolet radiation causes skin damage due to increased production of reactive oxygen species (ROS) and inflammatory intermediates and direct attack of DNA of skin cells. Astaxanthin is a reddish pigment that belongs to a group of chemicals called carotenoids and has protective effects as an antioxidant.

Objective: To determine the beneficial effects of astaxanthin on damaged human skin after exposure to ultraviolet radiation.

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Background: Cutaneous squamous cell carcinoma (cSCC) is the second most common nonmelanoma skin cancer worldwide. Recent studies have reported several genetic mutations in development of cSCC such as TP53, HRAS, and NOTCH1. Whole-exome sequencing (WES) of cSCC has not been reported in East Asian populations.

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Background: Botulinum toxin type A is widely used to treat primary axillary hyperhidrosis and has proven to be an effective and safe approach. Onabotulinumtoxin A was approved by the FDA as a treatment for primary axillary hyperhidrosis. This study aimed to evaluate the efficacy and safety of Neu-BoNT/A in subjects diagnosed with primary axillary hyperhidrosis.

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Sarcoidosis is a systemic granulomatous disease that affects a variety of organs. Although the etiology has not been fully understood, it is thought that diverse genetic and environmental factors interact with the immune system to develop granulomas. The incidence and death rate of sarcoidosis vary according to race.

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Background: Background: Hot springs have been traditionally used as an alternative treatment for a wide range of diseases, including rheumatoid arthritis, bronchial asthma, diabetes, hypertension, psoriasis and atopic dermatitis. However, the clinical effects and therapeutic mechanisms associated with hot springs remain poorly defined.

Objective: The purpose of this study was to demonstrate the different effects of hot springs on cellular viability and secretion of inflammatory cytokines on keratinocyte in two geographically representative types of hot springs: NaHCO-type and NaCl-type, which are the most common types in South Korea.

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Little is known about the comorbidities in actinic keratosis patients. To evaluate the association of actinic keratosis with certain malignancies. All patients with actinic keratosis (n = 61,438) and age- and sex-matched control subjects (n = 307,190) at a 5:1 ratio were enrolled using data from the Korean National Health Insurance Service between the years 2007 and 2014.

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  • * Researchers compared these patients to a control group of similar age and sex who did not have actinic keratosis, analyzing each for systemic inflammatory diseases before the skin diagnosis.
  • * The findings indicated that patients with actinic keratosis were more likely to have rheumatoid arthritis and psoriasis, but there was no significant link found with diseases like Behçet's, Crohn's, ulcerative colitis, or multiple sclerosis.
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This study analysed genomic mutations in basal cell carcinoma using whole exome sequencing of DNA specimens obtained from 20 Korean patients. Histological evaluation determined that 15 (75%) were low-risk basal cell carcinomas, and 5 (25%) were high-risk basal cell carcinomas. Seventy-five percent of the basal cell carcinomas harboured somatic mutations in hedge-hog pathway genes (PTCH1, 40% and SMO, 50%) and 45% harboured mutations in TP53.

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An eccrine poroma (EP) is a benign adnexal tumor that typically presents as a single lesion. Eccrine poromatosis defined as multiple EPs is an uncommon presentation. A 54-year-old male had undergone operation for stomach cancer 10 years prior and insisted that he had also taken adjuvant chemotherapy.

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No study has examined the associations between vitiligo and smoking. The purpose of this study was to investigate the incidence of vitiligo according to smoking status. We used clinical data from individuals aged over 20 years who received a health examination in the National Insurance Program between 2009 and 2012 (n = 23,503,807).

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Objective: Behçet disease (BD) is a chronic inflammatory multiorgan disease. An increased risk of cardiovascular disease (CVD) and heightened death rate with BD have been suggested, but to our knowledge, a nationwide large-scale study has not been conducted to date. This study aimed to determine the overall CV risk and death rate in patients with BD versus controls using the Korean National Health Insurance Service claim database.

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Background: Although several studies have reported a correlation between Behçet's disease (BD) and Parkinson's disease, this association has not yet been clarified.

Objective: To determine the risk of Parkinson's disease in patients with BD.

Methods: BD patients (n = 17,179; mean age, 51.

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