Synthesizing Conductive Metal-Organic Framework Nanosheets for High-Performing Chemiresistive Sensors.

Two-dimensional conjugated metal-organic frameworks (2D -MOFs) are emerging as unique electrode materials with great potential for electronic applications. However, traditional devices based on -MOFs often utilize them directly in the powder or nanoparticle form, leading to weak adhesion to the device substrate and resulting in low stability and high noise levels in the final device. In this study, we present a novel approach utilizing thin -MOFs synthesized via a general MOF nanosheet sacrifice approach, enhancing their aspect ratio and flexibility for high-performance electronic applications.

Impact of Different Greenspace Metrics on Cardiovascular Disease Incidence in Urban Settings: A Comparative Analysis.

Cardiovascular diseases (CVDs) are the leading cause of global mortality, and urban greenspace can reduce CVDs risk. However, the evidence relating various greenspace metrics to CVDs risk is inconclusive. To enhance the understanding of the correlation between greenspace and CVDs, we compared three greenspace indicators-street view-based greenspace (SVG), normalized difference vegetation index (NDVI), and green cover rate (GCR).

and evaluation of the effects of condensed tannins and catechins monomers on antioxidant and intestinal health of Chinese seabass ().

Plant-derived condensed tannins (CT) exhibit strong bioactivity of antioxidant, immunostimulation and intestinal protection, but with little clues of the mechanism of action. Since CT are consist of catechins (CAs) monomers, e.g.

An efficient electrolyte additive of quaternized hardwood kraft lignin enabling dendrite-free aqueous zinc-ion batteries.

Aqueous zinc-ion batteries (AZIBs) have great application potential in large-scale grid energy storage systems. However, the practical application of AZIBs is hindered by several serious issues arising from zinc anodes, such as hydrogen evolution, corrosion, and the formation of zinc dendrites and byproducts. In this study, renewable and low-cost hardwood kraft lignin was modified by the grafting of quaternary ammonium groups.

Exploring the repository of de novo-designed bifunctional antimicrobial peptides through deep learning.

Antimicrobial peptides (AMPs) are attractive candidates to combat antibiotic resistance for their capability to target biomembranes and restrict a wide range of pathogens. It is a daunting challenge to discover novel AMPs due to their sparse distributions in a vast peptide universe, especially for peptides that demonstrate potencies for both bacterial membranes and viral envelopes. Here, we establish a de novo AMP design framework by bridging a deep generative module and a graph-encoding activity regressor.

Detritivore identity modulates effects of nutrient enrichment and a common fungicide presence on leaf litter decomposition and fungal community.

Understanding the interaction of biotic and abiotic factors on ecosystem function is crucial for freshwater ecosystem management, However, the influence of nutrient enrichment, fungicide presence, and detritivore identity on leaf litter decomposition and associated fungal communities remains poorly understood. We conducted a microcosm experiment to examine: 1) the individual and combined effects of nutrient enrichment and a common fungicide on leaf litter decomposition and fungal communities; and 2) how two types of detritivore invertebrates (scrapers vs. shredders) influence these effects.

Quantum Well Superlattice Heteronanostructures for Efficient Photocatalytic Hydrogen Evolution.

In this study, we construct a quantum well effect-based two-dimensional Z-scheme superlattice heteronanostructure photocatalyst constructed from hydrogen-bonded porphyrin organic frameworks (HOFs) and carbon nitride. Porphyrin HOFs extend spectral absorption, while their π-conjugation and electron density variations significantly enhance charge separation and exhibit favorable alignment with the energy levels of carbon nitride, thereby enabling efficient charge transfer. Carboxylic acid channels in the HOFs further promote the decomposition of water molecules, thereby boosting hydrogen production.

Predicting post-hepatectomy liver failure using a nomogram based on portal vein width, inflammatory indices, and the albumin-bilirubin score.

Background: Post-hepatectomy liver failure (PHLF) after liver resection is one of the main complications causing postoperative death in patients with hepatocellular carcinoma (HCC). It is crucial to help clinicians identify potential high-risk PHLF patients as early as possible through preoperative evaluation.

Aim: To identify risk factors for PHLF and develop a prediction model.

Insights of Surface-Enhanced Raman Spectroscopy Detection by Guiding Molecules into Nanostructures to Activate Hot Spots.

A misunderstanding of how target molecules enter hot spot nanostructures has significantly hindered the advancement of surface-enhanced Raman spectroscopy (SERS) detection methods in recent years. The challenge lies in finding convenient ways to transport target molecules to various nanostructures. In this work, we discovered that filling the gaps in empty nanostructures with water is often difficult, as metal surfaces are not well wetted.

Tonoplast Sugar Transporters Coordinately Regulate Tomato Fruit Development and Quality.

Fruit yield and quality are antagonistically regulated traits in tomato. An excessive focus on increasing yield often leads to a decline in quality. How to achieve the delicate balance between high yield and desirable fruit quality is still a big challenge.

Mendelian non-syndromic and syndromic hearing loss genes contribute to presbycusis.

Age-related (AR) hearing loss (HL) is the most prevalent sensorineural disorder in older adults. Here we demonstrate that rare-variants in well-established Mendelian HL genes play an important role in ARHL etiology. In all we identified 32 Mendelian HL genes which are associated with ARHL.

Exploration of ammonia stripping coupled adsorption-membrane filtration process for treating kitchen waste biogas slurry.

The potential contamination of biogas slurry generated from the anaerobic digestion of kitchen waste (KW) poses a considerable challenge to its safe and effective utilization as a fertilizer. To tackle this problem, a novel route termed "AS-BC" was developed, integrating ammonia stripping (AS), biochar adsorption, and ceramic membrane filtration (CMF) for comprehensive pollutant mitigation. A stepwise optimization was carried out, comparing biochar adsorption investigation, the AS process, and the combined AS + CMF process.

The case-only design is a powerful approach to detect interactions but should be used with caution.

Background: The case-only design is a powerful approach to identify gene gene and gene environment interactions for complex traits. It has been demonstrated that for the case-only design to be valid the genetic and environmental factors must be independent in the population. Additionally, there is a rare disease assumption for the case-only design, but the impact of disease prevalence and other factors, e.

(E,E)-2,4-decadienal improved the stability of gelatin emulsion manufactured by low-energy stirring emulsification.

The study investigated the impact of varying concentrations of (E,E)-2,4-decadienal (DDE; 0, 9, 27, 54, and 81 μg/mL) on the stability of gelatin emulsions prepared via a low-energy stirring emulsification method, which relies solely on simple mechanical stirring. As the concentration of DDE increased, the emulsifying activity index, emulsion stability index, and viscosity of emulsions first increased significantly (P < 0.05) and then decreased significantly (P < 0.

Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is a common pediatric emergency primarily afflicting preterm infants, yet its mechanisms remain to be fully understood. Here, we report that plasma fibroblast growth factor (FGF)19, a target of farnesoid X receptor (FXR), was positively correlated with the clinical parameters of NEC. NEC patients and the NEC murine model displayed abundant FXR in intestinal epithelial cells (IECs), which was restricted by microbiota-derived short-chain fatty acids (SCFAs) under homeostasis.

Dispersion engineering for broadband visible microcombs via mode hybridization and inverse design.

We propose a reliable and simple approach for dispersion engineering in lithium niobate microring resonators (MRRs). With strong coupling-induced mode hybridization and inverse design method, we overcome the large normal dispersion and achieve broadband frequency comb coverage near 525 nm. We adopt a neural network method in the inverse design, which outperforms the traditional forward design based on manual trial-and-error and intuitive judgment.

Rational Construction of Layered Two-Dimensional Conjugated Metal-Organic Frameworks with Room-Temperature Quantum Coherence.

Two-dimensional conjugated metal-organic frameworks (2D c-MOFs) have emerged as an intriguing class of quantum materials due to their high crystallinity, persistent spin centers, and tunable structures and topologies. However, it remains unclear how to achieve long spin relaxation time at room temperature in 2D c-MOFs via a bottom-up design strategy. Herein, we design a hexahydroxytrithiatruxene ligand (HHTH) to minimize the influence of nuclear spin on electron spin relaxation while weakening -π conjugation to construct a "spin docking" for preserving spin centers, which enables the resulting 2D c-MOFs, NiHHTH, to exhibit quantum coherence and Rabi oscillations at room temperature.

1.55 GHz balanced homodyne detector with high gain flatness based on low noise amplifier.

In this paper, a model for simulating the shot noise power and the electronic noise power of a balanced homodyne detector (BHD) using cascaded low noise amplifiers (LNAs) is presented. Moreover, the factors influencing the enhancement of BHD gain flatness are analyzed. Based on these theories, a BHD with a large clearance between shot noise and electronic noise, along with a flat broadband frequency response, is designed using LNAs and an optimized printed circuit board design.

Discovery of Novel Pyrrolo[2,3-]pyridine-Based CSF-1R Inhibitors with Demonstrated Efficacy against Patient-Derived Colorectal Cancer Organoids.

Repolarizing M2-like tumor associated macrophages (TAMs) into M1 phenotype by blocking CSF-1/CSF-1R signaling pathway represents a promising strategy to remodel the tumor immune microenvironment. Therefore, the discovery of novel potent CSF-1R inhibitors is of great significance for colorectal cancer immunotherapy. In this work, a series of novel CSF-1R inhibitors were designed and synthesized through rational molecular hybridization strategy and step by step structural optimization based on PLX3397 and BLZ945.

Ubiquitin-conjugating enzyme gene SgUBC2 confers manganese tolerance in Stylosanthes guianensis through antioxidant defense augmentation and manganese-responsive gene regulation.

Stylo (Stylosanthes guianensis) is an important tropical legume with superior tolerance to manganese (Mn) toxicity, which severely constrains plant growth, especially in tropical acid soils. However, the mechanisms underlying Mn tolerance in stylo remain largely unknown. In this study, excess Mn-caused growth inhibition was observed in stylo shoots but not roots, accompanied by increased activities of superoxide dismutase and catalase, as well as elevated concentrations of ascorbate and glutathione, which may contribute to oxidative stress scavenging under Mn toxicity.

Biohybrid microrobots with a Spirulina skeleton and MOF skin for efficient organic pollutant adsorption.

Wastewater treatment is a key component in maintaining environmental health and sustainable urban life, and the rapid development of micro/nanotechnology has opened up new avenues for more efficient treatment processes. This work developed a novel biohybrid microrobot for the efficient adsorption of a series of organic pollutants in water-the microrobot with a biodegradable Spirulina skeleton and biocompatible ZIF-8 skin. The microrobot not only has a low-cost and simple preparation method but also shows attractive propulsion in various contaminant solutions (including rhodamine B, methylene blue, and methyl orange) under a low-intensity (3 mT) rotating magnetic field and has excellent directional control.

Risk of Cervical Carcinoma After Unfavorable Behavior and High Genetic Risk in the UK Biobank: A Prospective Nested Case-Control Study.

: Previous studies have established a general understanding of the association between risky sexual behavior, genetic risk, and cervical carcinoma. However, these studies were conducted several years ago and lack systematic analysis using high-quality and population-based data. : We conducted a prospective nested case-control study to identify risky behaviors and developed a behavior score.

Psychological safety and psychosocial safety climate in workplace: A bibliometric analysis and systematic review towards a research agenda.

Introduction: Research on workplace safety has seen significant growth in academic and industry-focused literature over the past 20 years. However, the extant literature on workplace safety tends to focus on safety outcomes of physical accidents and injuries while relegating its conceptual and theoretical development to the background. Psychological safety and psychosocial safety climate in the workplace are essential to workers' health and safety.

Cerebrospinal fluid and serum cytokine profiles in severe viral encephalitis with implications for refractory status epilepticus: a retrospective observational study.

Background: To identify new intervention targets, we explored the correlation between cytokines and the development of refractory status epilepticus (RSE) in patients with severe viral encephalitis (SVE).

Methods: We examined the characteristics of 14 cytokines in the cerebrospinal fluid (CSF) and serum, analyzing their correlation with acute symptomatic seizures and prognosis. Furthermore, we conducted a dynamic analysis of differences and correlations in the expression of cytokines among patients with SVE without seizures, those with controlled seizures, and those with RSE.

Designing hydrogel for application in spinal surgery.

Spinal diseases and injuries are prevalent in clinical settings and impose a substantial burden on healthcare systems. Current treatments for spinal diseases are predominantly limited to surgical interventions, drug injections, and conservative treatments. Generally, these treatment modalities have limited or no long-term benefits.