Monochromatic Responsive HOF Heterostructures via VIA-Group-Based Framework Hybridization for Fully-Covert Photonic Barcode.

Luminescent responsive heterostructures with region-domained emission and integrated responsiveness exhibit great potential in information security, but always suffer from the direct exposure of fingerprint information at the initial state, making it easy to decode the hidden confidential information. Herein, the first monochromatic responsive hydrogen-bonded organic framework (HOF) heterostructures are reported based on VIA-group-based framework hybridization toward fully-covert photonic barcodes. Designed HOF blocks with different VIA-group elements are integrated via a configuration-assimilation-based assembly method to generate the intrinsic monochromatic HOF heterostructures.

Stereoselective synthesis of a KRAS inhibitor with a quinoline-piperazine scaffold.

We developed a novel synthetic route for the KRAS inhibitor, focusing on the efficient construction of its central quinoline scaffold. The method offers several advantages: eliminates the formation of regioselective by-products and avoids the use of high temperatures and nitric acid. The last step of the overall route enables gentle hydrolysis of phenyl esters with methanol and potassium carbonate, which greatly reduces the occurrence of side reactions.

Difunctionalization of Alkenes toward 3,3-Disubstituted and Dihydrobenzoindolines by Using an Imidazolylidene Palladacyclic Catalyst.

The synthesis of valuable 2a,3-dihydrobenzo[]indolines was successfully achieved by combining IPr-Pd-Oxa-catalyzed cross-coupling and proton-induced hydroarylation in a one-pot method. In situ-generated alkynyl-functionalized 3,3-disubstituted indolines were proved as the key intermediate, bearing a broad scope of substrates with diverse functional groups and electronic properties.

Evaluative Methodology for HRD Testing: Development of Standard Tools for Consistency Assessment.

Homologous recombination deficiency (HRD) has emerged as a critical prognostic and predictive biomarker in oncology. However, current testing methods, especially those reliant on targeted panels, are plagued by inconsistent results from the same samples. This highlights the urgent need for standardized benchmarks to evaluate HRD assay performance.

Automated segmentation by SCA-UNet can be directly used for radiomics diagnosis of thymic epithelial tumors.

Background: Automatic segmentation of thymic lesions in preoperative computed tomography (CT) images is crucial for accurate diagnosis but remains time-consuming. Although UNet is widely used in medical imaging, its performance is limited by the inherent drawbacks of convolutional neural networks (CNNs), such as restricted receptive fields and limited global context modeling, which affect segmentation efficiency.

Method: 712 patients with mediastinal lesions admitted to Shanghai General Hospital between October 2014 and January 2023 were included in the study.

d-π Orbital Interaction Promoting NO Selective Reduction on the Mn-Doped α-FeO(001) Catalyst.

Understanding the structure-activity relationship on a solid surface is crucial for developing an efficient low-temperature NH-SCR catalyst. Herein, an in-depth investigation was conducted on a single-atom Mn-doped α-FeO catalyst by combining experimental studies and density functional theory calculations. Mn doping not only facilitates N-H cleavage in the Eley-Rideal (E-R) pathway but also promotes the adsorption of NO and the cleavage of the N-O bond, lowering the energy barrier of the rate-determining step in the Langmuir-Hinshelwood (L-H) pathway.

Investigation and study on the epidemiology of gestational diabetes mellitus in Guizhou.

Background: Gestational diabetes mellitus (GDM) is a growing public health concern, particularly in regions with diverse ethnic populations. Understanding the incidence and risk factors of GDM is crucial for early prevention and management, especially in underrepresented areas like Guizhou Province, China, where geographic and ethnic diversity may influence the disease's prevalence and risk profiles.

Aim: To investigate the incidence of GDM and identify its associated risk and protective factors among different ethnic groups in Guizhou Province, providing essential data for early prevention strategies.

Classification of acute myeloid leukemia based on multi-omics and prognosis prediction value.

Acute myeloid leukemia (AML) is a heterogeneous cancer, making outcomes prediction challenging. Several predictive and prognostic models are used but have considerable inaccuracy at individual level. We tried to increase prediction accuracy using a multi-omics strategy.

Constructing SiO-Supported Atomically Dispersed Platinum Catalysts with Single-Atom and Atomic Cluster Dual Sites to Tame Hydrogenation Performance.

Construction and optimization of stable atomically dispersed metal sites on SiO surfaces are important yet challenging topics. In this work, we developed the amino group-assisted atomic layer deposition strategy to deposit the atomically dispersed Pt on SiO support for the first time, in which the particle size and ratio of Pt entities from single atom (Pt) to atomic cluster (Pt ) and nanoparticle (Pt ) on the SiO surface were well modulated. We demonstrated the importance of dual-site synergy for optimizing the activity of single-atom catalysts.

CmTGA8-CmAPX1/CmGSTU25 regulatory model involved in trehalose induced cold tolerance in oriental melon seedlings.

Plants have developed complex regulatory networks to adapt to various stresses, including cold stress. Trehalose (Tre), known as the "sugar of life," plays a crucial role in enhancing cold tolerance by triggering antioxidation. However, the underlying regulatory mechanisms remain unclear.

A novel technique for rapid localization of pulmonary nodules on-site in operating room followed by lung resection: a case series.

Background: The localization of pulmonary nodules is crucial for surgical intervention. However, a safe, simple, and efficient method remains elusive. This study aims to evaluate the safety and feasibility of a newly developed preoperative localization method for pulmonary nodules called Rapid Localization of Pulmonary Nodules On-Site (RLPN-OS).

A comprehensive retrospect on the current perspectives and future prospects of pneumoconiosis.

Pneumoconiosis is a widespread occupational pulmonary disease caused by inhalation and retention of dust particles in the lungs, is characterized by chronic pulmonary inflammation and progressive fibrosis, potentially leading to respiratory and/or heart failure. Workers exposed to dust, such as coal miners, foundry workers, and construction workers, are at risk of pneumoconiosis. This review synthesizes the international and national classifications, epidemiological characteristics, strategies for prevention, clinical manifestations, diagnosis, pathogenesis, and treatment of pneumoconiosis.

A Deep Learning Approach for Mental Fatigue State Assessment.

This study investigates mental fatigue in sports activities by leveraging deep learning techniques, deviating from the conventional use of heart rate variability (HRV) feature analysis found in previous research. The study utilizes a hybrid deep neural network model, which integrates Residual Networks (ResNet) and Bidirectional Long Short-Term Memory (Bi-LSTM) for feature extraction, and a transformer for feature fusion. The model achieves an impressive accuracy of 95.

Targeted Modulation of the Meningeal Lymphatic Reverse Pathway for Immunotherapy of Breast Cancer Brain Metastases.

Treatment of tumor brain metastases remains challenging due to the ineffectiveness of drugs in crossing the blood-brain barrier (BBB). Here, we proposed a potential strategy to target and modulate the meningeal lymphatic system for immunotherapy of breast cancer brain metastases (BCBM) through peripheral administration. CT/fluorescence dual-modality imaging demonstrated that the phospholipid nanoprobe (α-PLNPs) through intracisternal magna injection effectively labeled and long-range tracked the meningeal lymphatic pathway from meningeal lymphatic vessels (MLVs) to periphery drainage cervical lymph nodes (CLNs).

Late-Stage C-H Functionalization of Dehydroalanine-Containing Peptides with Arylthianthrenium Salts and Its Application in Synthesis of Tentoxin Analogue.

Dehydrophenylalanine has a characteristic unsaturated double bond that makes it indispensable in the context of peptides and proteins. In this study, we report the Pd-catalyzed C(sp)-H arylation of dehydroalanine-containing peptides with arylthianthrenium salts under mild and base free conditions, which provides efficient access to dehydrophenylalanine-containing peptides. This approach enables the efficient coupling of different drug scaffolds and bioactive molecules to the peptides.

Striking Improvement of N Selectivity in NH Oxidation Reaction on FeO-Based Catalysts via SiO Doping.

The emission of NH has been reported to pose a serious threat to both human health and the environment. To efficiently eliminate NH, catalysts for the selective catalytic oxidation of NH (NH-SCO) have been intensively studied. FeO-based catalysts were found to exhibit superior NH oxidation activity; however, the low N selectivity made it less attractive in practical applications.

Exploring B7-H4's role in prostate cancer dormancy post-androgen deprivation therapy: extracellular matrix interactions and therapeutic opportunities.

Prostate cancer (PCa) is mainly managed with androgen deprivation therapy (ADT), but this often leads to a dormant state and subsequent relapse as lethal castration-resistant prostate cancer (CRPC). Using our unique PCa patient-derived xenograft (PDX) dormancy models, we investigated this critical dormant phase and discovered a selective increase in B7-H4 expression during the dormancy period following mouse host castration. This finding is supported by observations in clinical specimens of PCa patients treated with ADT.

Multipopulation Whale Optimization-Based Feature Selection Algorithm and Its Application in Human Fall Detection Using Inertial Measurement Unit Sensors.

Feature selection (FS) is a key process in many pattern-recognition tasks, which reduces dimensionality by eliminating redundant or irrelevant features. However, for complex high-dimensional issues, traditional FS methods cannot find the ideal feature combination. To overcome this disadvantage, this paper presents a multispiral whale optimization algorithm (MSWOA) for feature selection.

Anthropogenic Drivers of Small-Island Effects in Urban Remnant Woody Plants.

The positive relationship between species richness and area is a fundamental principle in ecology. However, this pattern deviates on small islands, where species richness either changes independently of area or increases at a slower rate-a phenomenon known as the Small-Island Effect (SIE). While the SIE has been well documented in natural ecosystem, its presence in highly fragmented and disturbed urban ecosystem remains unexplored, posing challenges for urban vegetation conservation.

Visual detection of ciprofloxacin using a multi-emission ratiometric fluorescence sensor based on the molecularly imprinted polymers doped with terbium(III) ions.

Ciprofloxacin (CIP) is a commonly used antibiotic, but its abuse may cause bacterial resistance, posing a high risk to the environment and human health. Herein, based on the molecular imprinting technology, this study proposed a ratiometric fluorescence sensor employing the "post-doping" strategy, which aims to be rapid, selective, and visually easy-to-use for CIP detection to address antibiotic residues and environmental risks. Specifically, by exploiting the "antenna effect" of lanthanide metal ions (Ln), terbium (III) (Tb) chosen as a fluorescence-assisted functional monomer as well as the red emitting CdTe quantum dots (QDs) as the internal reference signal were introduced into multi-emission Tb-CdTe@SiO@MIPs (TbMIPs).

Advancements in flexible biomechanical energy harvesting for smart health applications.

Advancing flexible electronics enables timely smart health management and diagnostic interventions. However, current health electronics typically rely on replaceable batteries or external power sources, requiring direct contact with the human skin or organs. This setup often results in rigid and bulky devices, reducing user comfort during long-term use.

Recovery in soil carbon stocks but reduced carbon stabilization after near-natural restoration in degraded alpine meadows.

Near-natural restoration is acknowledged as an effective strategy for enhancing soil organic carbon (SOC) sequestration in degraded grasslands. However, the alterations in SOC fractions, stability, and relative sequestration capacity after restoration of degraded alpine meadows remain uncertain. In this study, we utilized the degraded alpine meadows on the northeastern edge of the Tibetan Plateau as a research area, with grazing as the control (CK) and restoration of 20 years of banned grazing (BG) and growing season resting grazing (RG).

Classifying intentions for carbon neutrality participation through latent class analysis.

This study aims to classify citizens' intentions to participate in carbon neutrality activities, emphasizing the crucial role of public engagement in achieving sustainability goals amid the climate crisis. The climate crisis has rapidly become one of the most pressing challenges to global sustainable development, with carbon neutrality as a key objective. To understand variations in citizens' willingness to engage in carbon neutrality efforts, we conducted a Latent Class Analysis (LCA) on responses from 800 residents of Cheongju, South Korea, categorizing their willingness to participate in 13 different carbon neutrality activities.

Cx43 Regulates Nicotine-Induced Proliferation and Migration of Distal Pulmonary Artery Smooth Muscle Cells by the ERK1/2 Signaling Pathway.

Pulmonary hypertension is a progressive disease associated with remodeling of the pulmonary vasculature. Excessive proliferation and migration of pulmonary artery smooth muscle cells (PASMCs) play important roles in nicotine-induced vascular injury. Connexin 43 (Cx43) is involved in intracellular communication and regulation of the pulmonary vasculature.