Preclinical metabolism and metabolic drug-drug interaction profile of pedunculoside and rotundic acid.

Pedunculoside and rotundic acid, the most abundant components in plants of the genus Ilex L. (Aquifoliaceae), exhibit biological and pharmacological significance in the treatment of cardiovascular diseases. However, there have been few studies on their metabolism.

Total Reflection X-ray Fluorescence Spectrometry: A Comprehensive Review of Critical Components, Analytical Benefits and Practical Applications.

Total reflection X-ray fluorescence spectrometry (TXRF) is a pivotal technique in modern atomic spectroscopy, distinguished by its capability for multi-element simultaneous determination, a wide dynamic concentration range, samples do not require acid digestion. Additionally, TXRF exhibits negligible matrix effects when samples are prepared as thin films. Based on these unique features, recent research efforts have increasingly employed laboratory-built TXRF systems for the determination of major and trace elements in various samples.

Liver function abnormality on admission predicts long COVID syndrome in digestive system.

Background: Clinical practice showed that many patients with SARS-CoV-2 infection presented with long COVID syndrome in digestive system. We sought to investigate the factor affecting the incidence of long COVID syndrome in digestive system.

Methods And Results: Patients with SARS-CoV-2 infection diagnosed at two centers of Zhongshan Hospital and one center of Shanghai Pudong Hospital from March 01, 2022 to May 31, 2022 were enrolled, collected in the hospital database, and followed up until March 30, 2023.

Phosphination of aryl/alkyl bromides Mn-mediated reductive C-P coupling.

Mn-mediated reductive cross-coupling of organic bromides with 2-bromo-1,3,2-diazaphospholene was developed for efficient construction of C-P bonds under mild conditions. Mechanistic studies suggested that bromides are activated by formed bis-diazaphospholene hybrid radical and polar mechanisms.

Intraoperative Communication Among Men and Women Surgeons With Nursing and Anesthesia Providers.

Introduction: Gender bias has been reported by women surgeons, but its impact on communication in the operating room (OR) is unclear. OR communication is critical to understand, as it directly impacts patient outcomes. The current study evaluates potential gender bias in the type and quality of communication between surgeons and OR nursing and anesthesia providers.

Boron-Doping Engineering in AgCd Bimetallic Catalyst Enabling Efficient CO Electroreduction to CO and Aqueous Zn-CO Batteries.

The limited adsorption and activation of CO on catalyst and the high energy barrier for intermediate formation hinder the development of electrochemical CO reduction reactions (CORR). Herein, this work reports a boron (B) doping engineering in AgCd bimetals to alleviate the above limitations for efficient CO electroreduction to CO and aqueous Zn-CO batteries. Specifically, the B-doped AgCd bimetallic catalyst (AgCd-B) is prepared via a simple reduction reaction at room temperature.

Shatianyu ( L. Osbeck) whole fruit alleviated loperamide-induced constipation enhancing gut microbiota-mediated intestinal serotonin secretion and mucosal barrier homeostasis.

This study aims to explore the effects of Shatianyu ( L. Osbeck) whole fruit powder (SWFP) enriched in flavonoids and dietary fiber on loperamide-induced constipation after a 4-week administration in the diet, together with possible microbiota-mediated mechanisms. The SWFP intervention shortened the first defecation time and increased defecation frequency; it also increased the serum serotonin (5-HT) level and decreased the LPS level in constipation mice.

Associations of age and sex with characteristics of extracellular vesicles and protein-enriched fractions of blood plasma.

Extracellular vesicles (EVs) are nanosized particles that are released by various cell types and play vital roles in intercellular communication. They carry biological molecules reflecting the physiological and pathological states of their source cells and tissues, showing potential as biomarkers. However, the impact of demographic factors like age and sex on the properties of blood plasma EVs remains underexplored.

Degradation of extracellular antibiotic resistance gene through singlet oxygen produced by carbon nanotubes-activated persulfate.

Extracellular antibiotic resistance gene (eARG) has emerged as a global crisis in recent years, yet commonly used disinfectants have proven ineffective for their elimination. Seeking to enhance the degradation efficiency of eARG, this study explored the potential of carbon nanotubes-activated persulfate (CNTs + PS) system as a novel method for eradicating eARG. Our findings demonstrated that CNTs + PS effectively disrupted the intact structure of eARG, inhibited their genetic replication and horizontal transfer capability, achieving remarkable degradation of eARG contamination.