Publications by authors named "Dong Kyoung Chang"
Factors associated with vaccination among inflammatory bowel disease patients in Korea.
Korean J Gastroenterol
April 2013
Background/aims: Vaccinations are generally recommended in patients with inflammatory bowel disease (IBD). However, several studies showed low rates of vaccinations in IBD patients. Furthermore, vaccination rate among IBD patients in Korea has never been investigated.
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- The study aimed to find epigenetic markers in plasma that could help detect colorectal cancer at an early stage.
- Researchers analyzed the methylation patterns of 10 genes in tissue and plasma samples from patients with colorectal cancer and healthy individuals, using a method called methylation-specific PCR.
- The findings suggested that specific genes (APC, MGMT, RASSF2A, and Wif-1) could serve as effective biomarkers, showing high sensitivity (86.5%) and specificity (92.1%) for early detection of the disease in plasma samples.
This study was aimed at investigating the involvement of the SUV39H1 histone methyltransferase on the epigenetic change of euchromatic promoter in colorectal cancer. We retrospectively analyzed the mRNA levels of SUV39H1 and the promoter methylation of the p14(ARF), p16(INK4a) and HLTF genes as well as the mRNA levels of DNA methyltransferase 1 (DNMT1) in fresh frozen tissues from 219 colorectal cancer patients. The mRNA levels of the SUV39H1 and DNMT1 were assessed via quantitative real-time PCR and the methylation profiles of the CpG islands were determined using methylation-specific PCR.
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