Publications by authors named "Dong Kuai"
Article Synopsis
- - The study investigates the link between the most recent ischemic event (either a transient ischemic attack [TIA] or stroke) and the risk of subsequent strokes in patients with symptomatic artery occlusion receiving medical treatment.
- - It involved 165 patients, comparing those with TIAs to those with strokes, and found no significant difference in the incidence of ipsilateral ischemic strokes, showing a rate of 13.3% for TIAs and 6.7% for strokes.
- - The conclusions indicate that patients experiencing a TIA are not at a lower risk for future strokes compared to those who have had a stroke, suggesting similar risks regardless of the prior event.
Article Synopsis
- The study explores the link between body mass index (BMI) and the risk of ischemic stroke in patients with blocked arteries, aiming to see if BMI can help identify those who might need surgery.
- Out of 165 patients treated only with medical management, 9.7% experienced a stroke, with higher BMIs showing a stronger connection to this risk; the critical BMI cutoff was identified at 24.5 kg/m².
- Patients with a BMI ≥24.5 kg/m² benefited more from surgical bypass compared to those with lower BMIs, suggesting the need for further large studies to solidify these results.
Article Synopsis
- The study looked at patients with severe strokes who were treated successfully but still had bad outcomes or deaths in the following 90 days.
- It involved 207 people from a trial in China and found that 38% had poor results, while 12.6% died after treatment.
- Key risk factors for dying or having bad outcomes included being older than 67, having specific types of artery blockage, and having a high initial stroke severity score.
Importance: Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit for stroke prevention in patients with atherosclerotic occlusion of the internal carotid artery (ICA) or middle cerebral artery (MCA), but there have been subsequent improvements in surgical techniques and patient selection.
Objective: To evaluate EC-IC bypass surgery in symptomatic patients with atherosclerotic occlusion of the ICA or MCA, using refined patient and operator selection.
Design, Setting, And Participants: This was a randomized, open-label, outcome assessor-blinded trial conducted at 13 centers in China.
Article Synopsis
- The study aimed to compare the safety and efficacy of the Neurohawk retriever and the Solitaire FR for treating acute ischemic stroke caused by large vessel occlusion, using a randomized controlled trial with a focus on non-inferiority.
- A total of 232 patients participated, showing a successful reperfusion rate of 88.70% for Neurohawk and 90.60% for Solitaire, with no significant differences in safety outcomes or overall effectiveness between the two devices.
- Subgroup analyses indicated that both devices performed similarly in terms of outcomes, regardless of whether the strokes were caused by intracranial atherosclerotic disease or other factors, with comparable rates of all-cause mortality within 90 days.
The present study aimed to investigate potential gene markers for predicting the formation of carotid atheroma plaques using high‑throughput bioinformatics methods. The GSE43292 gene expression profile was downloaded from the Gene Expression Omnibus database. Following data processing, differentially expressed genes (DEGs) were screened using a paired t‑test in the Linear Models for Microarray Data package with the criteria of a false discovery rate of P<0.
View Article and Find Full Text PDFBackground: Patients with symptomatic internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion with haemodynamic insufficiency are at high risk for recurrent stroke when treated medically.
Methods: The Carotid or Middle cerebral artery Occlusion Surgery Study (CMOSS) trial is an ongoing, government-funded, prospective, multicentre, randomised controlled trial. The CMOSS will recruit 330 patients with symptomatic ICA or MCA occlusion (parallel design, 1:1 allocation ratio) and haemodynamic insufficiency.
MicroRNA (miR)-497 plays a tumor-suppressive role in several malignancies and is involved in glioma invasiveness and resistance to chemotherapy. To add to the knowledge of the clinical significance of miR-497 in human gliomas, quantitative real-time polymerase chain reaction was performed to detect the expression of miR-497 in 110 pairs of freshly prepared glioma and nonneoplastic brain tissues. Then the associations of miR-497 expression with various clinicopathological characteristics and overall survival of glioma patients were estimated statistically.
View Article and Find Full Text PDFBackground: FRAT1 positively regulates the Wnt/β-catenin signaling pathway by inhibiting GSK-3-mediated phosphorylation of β-catenin. It was originally characterized as a protein frequently rearranged in advanced T cell lymphoma, but has recently also been identified as a proto-oncogene involved in tumorigenesis. Our previous studies showed that FRAT1 was dramatically overexpressed in gliomas and its expression level was significantly increased along with clinicopathological grades.
View Article and Find Full Text PDF