MRI-based Deep Learning Algorithm for Assisting Clinically Significant Prostate Cancer Detection: A Bicenter Prospective Study.

Background Although artificial intelligence is actively being developed for prostate MRI, few studies have prospectively validated these tools. Purpose To compare the diagnostic performance of a commercial deep learning algorithm (DLA) and radiologists' clinical reports for cancer detection in participants from two hospitals using histopathologic findings from biopsy specimens as the reference standard. Materials and Methods This prospective bicenter study enrolled participants suspected of having prostate cancer (PCa) who were scheduled for biopsy based on clinical information, including prostate MRI, from December 2022 to July 2023.

Novel approach to upcycling food processing biomass: development of rice snacks using rice bran emulsifier.

This study addresses the need for innovative approaches to upcycling rice bran as a biomass resource. A novel upcycling ingredient derived from rice bran was developed, and its application in the production of rice crackers with enhanced texture was explored. The effects of different emulsifier types and concentrations on the texture, flavor, and overall quality of rice crackers-by influencing the uniformity of oil and moisture in the formulation-were confirmed through systematic analytical methods.

Preoperative Prediction Model for Early Recurrence of Intrahepatic Cholangiocarcinoma After Surgical Resection: Development and External Validation Study.

Purpose: We aimed to develop a preoperative risk scoring system to predict early recurrence (ER) of intrahepatic cholangiocarcinoma (ICCA) after resection, utilizing clinical and computed tomography (CT) features.

Materials And Methods: This multicenter study included 365 patients who underwent curative-intent surgical resection for ICCA at six institutions between 2009 and 2016. Of these, 264 patients from one institution constituted the development cohort, while 101 patients from the other institutions constituted the external validation cohort.

Effect of combining serum alpha-fetoprotein with LI-RADS v2018 on gadoxetate-enhanced MRI in the diagnosis and prognostication of hepatocellular carcinoma.

Objectives: To evaluate the performance of combining serum alpha-fetoprotein (AFP) with LI-RADS (LI-RADS + AFP) on gadoxetate-enhanced MRI for diagnosing hepatocellular carcinoma (HCC) ≤ 3.0 cm and predicting post-surgical patient outcomes, compared to LI-RADS v2018.

Methods: Patients with hepatic observations ≤ 3.

Inter-reader reliability of Ovarian-Adnexal Reporting and Data System US: a systematic review and meta-analysis.

Purpose: Ovarian-Adnexal Reporting and Data System (O-RADS) US provides a standardized lexicon for ovarian and adnexal lesions, facilitating risk stratification based on morphological features for malignancy assessment, which is essential for proper management. However, systematic determination of inter-reader reliability in O-RADS US categorization remains unexplored. This study aimed to systematically determine the inter-reader reliability of O-RADS US categorization and identify the factors that affect it.

Evaluating Meniscus, Ligament and Soft Tissue Injury Using MRI in Tibial Plateau Fractures: A Tscherne Classification Approach.

: This study investigated associated meniscus and ligament injuries in tibial plateau fractures using magnetic resonance imaging (MRI) and assessed soft tissue injuries in relation to the Schatzker classification and Tscherne classification. : The data of 185 patients who sustained tibial plateau fractures from January 2010 to April 2021 were retrospectively reviewed. Fractures were classified according to the Schatzker classification system.

Up-regulation of Melanophilin (MLPH) gene during avian adipogenesis and decreased fat pad weights with adipocyte hypotrophy in MLPH knockout quail.

Advanced genetic and nutritional strategies aimed at modulating fat deposition can significantly reduce production costs and enhance profitability in the poultry industry. Melanophilin (MLPH) is recognized as a key gene regulating pigmentation as shown by diluted hair and feather coloration in MLPH mutant animals, including avian models. However, the effects of MLPH during fat accretion have not been studied yet.

Enhanced Synaptic Memory Window and Linearity in Planar InSe Ferroelectric Junctions.

A synaptic memristor using 2D ferroelectric junctions is a promising candidate for future neuromorphic computing with ultra-low power consumption, parallel computing, and adaptive scalable computing technologies. However, its utilization is restricted due to the limited operational voltage memory window and low on/off current (I) ratio of the memristor devices. Here, it is demonstrated that synaptic operations of 2D InSe ferroelectric junctions in a planar memristor architecture can reach a voltage memory window as high as 16 V (±8 V) and I ratio of 10, significantly higher than the current literature values.

A 2-oxoglutarate-dependent dioxygenase, GLUCORAPHASATIN SYNTHASE 1 (GRS1) is a major determinant for different aliphatic glucosinolates between radish and Chinese cabbage.

Glucosinolates (GSLs) are secondary metabolites in Brassicaceae plants and play a defensive role against a variety of abiotic and biotic stresses. Also, it exhibits anti-cancer activity against cancer cell in human. Different profiles of aliphatic GSL compounds between radish and Chinese cabbage were previously reported.

Electrical transport phenomena in two-dimensional metallic 2H-NbSe: an experimental and theoretical study.

Two-dimensional (2D) metallic transition metal dichalcogenides (TMDCs) have attracted extensive interest in various fields owing to their unique electronic properties. However, studies on their transport properties and the modulation of these properties based on their band structure are limited. Herein, we studied the transport phenomena in 2D metallic 2H-NbSe using experimental and theoretical approaches.

Effects of Length-to-Width Ratio on Magnetic and Microstructural Properties of Die-Upset Nd-Fe-B Magnets.

In this study, the effects of the length-to-width ratio on the magnetic and microstructural properties of die-upset Nd-Fe-B magnets were examined. A die-upset magnet with a uniform shape and no significant cracking was successfully developed. During the die-upset process, the applied pressure was not uniform across the magnet and varied depending on its shape and position.

Sinapine suppresses ROS-induced C2C12 myoblast cell death through MAPK and autophagy pathways.

Oxidative stress in skeletal muscle can lead to muscle atrophy through reactive oxygen species (ROS)-induced damage and cell death. -Butyl hydroperoxide (TBHP), an exogenous ROS generator, induces oxidative stress and cell death in various cells. Sinapine from cruciferous plants possesses beneficial effects, but its role in protecting skeletal muscle cells against ROS-induced cell death remains unclear.

Heart-specific expression of the green fluorescent protein gene in avian embryos by administration of recombinant adenovirus type-5 vector into the embryonic blood vessel.

Genetic modification could provide direct functions of genes that could potentially contribute to diverse areas of research including genetics, developmental biology, and physiology. It has been reported that genes of interest could be introduced via recombinant adenovirus type 5 (Ad5) in poultry. Successful gene delivery to mammal fetuses promises substantial progress in clinical and developmental biology, but it is limited because of difficulties in injecting specific sites and invasiveness.

A skin-interfaced microfluidic platform supports dynamic sweat biochemical analysis during human exercise.

Blood lactate concentration is an established circulating biomarker for measuring muscle acidity and can be evaluated for monitoring endurance, training routines, or athletic performance. Sweat is an alternative biofluid that may serve similar purposes and offers the advantage of noninvasive collection and continuous monitoring. The relationship between blood lactate and dynamic sweat biochemistry for wearable engineering applications in physiological fitness remains poorly defined.

Multi-Load Topology Optimization Design for the Structural Safety Maintenance of Low- and Intermediate-Level Radioactive Waste Packaging Containers in the Case of a Collision.

This paper presents an optimized design approach using nonlinear dynamic analysis and finite element methods to ensure the structural integrity of square-shaped containers made from ductile cast iron for intermediate- and low-level radioactive waste packaging. Ductile cast iron, with its spherical graphite structure, effectively distributes stress throughout the material, leading to a storage capacity increase of approximately 18%. Considering the critical need for containers that maintain integrity under extreme conditions like earthquakes, the design focuses on mitigating stress concentrations at the corners of square structures.

Development of 3D compound structures and highly wettable carbonate hydroxide electrodes for high-performance supercapacitors.

A facile hydrothermal method was employed to fabricate tailored NiCo(CO)(OH) electrodes for high-performance supercapacitors. Ni and Co ions, transition metals with versatile oxidation states, were used, promoting redox reactions. Additionally, a comparative analysis of the characteristics and electrochemical properties between electrodes fabricated with 3D Ni foam substrates and those without substrates was conducted.

Blood culture bottles meet the operating room: enhancing the diagnostic accuracy of infectious spondylitis through open microsurgical biopsy and intraoperative inoculation.

Purpose: Infectious spondylitis is caused by hematogenous seeding or adjacent soft tissue infection. No study has provided evidence that incubating biopsy specimens in blood culture bottles could enhance detection rates, nor has any study compared this method with conventional culture techniques. We aimed to assess the diagnostic yield of open microsurgical biopsies for infectious spondylitis and the efficacy of various culture media in the presence and absence of pre-biopsy antibiotic therapy.

RECIST 1.1, mRECIST, and Choi criteria for evaluating treatment response and survival outcomes in hepatocellular carcinoma patients treated with atezolizumab plus bevacizumab.

Objectives: We aimed to compare the early responder rates, defined as complete or partial responders, using response evaluation criteria in solid tumors (RECIST) 1.1, modified RECIST (mRECIST), and Choi criteria in advanced HCC patients treated with atezolizumab-bevacizumab (atezo-bev), and to correlate them with progression-free survival (PFS) and overall survival (OS).

Methods: This retrospective study included advanced HCC patients treated with ≥ 3 cycles of atezo-bev.

Predictive Value of Bolster Supine X-Ray for the Correction of Segmental Deformity After Thoracolumbar Fusion Surgery.

Background And Objectives: Assessment of thoracolumbar spine flexibility is crucial for determining which osteotomy to perform (posterior column osteotomy or 3-column osteotomy) to restore sagittal balance. Although preoperative bolster supine X-rays have been used to evaluate spine flexibility, their correlation with postoperative spinopelvic parameters has not been reported. We aimed to evaluate the predictive value of bolster X-ray for correcting sagittal deformities after thoracolumbar fusion surgery.