Intact N-glycopeptide analysis of human platelets reveals a Glycostructure important for platelet function.

Glycosylation is an important posttranslational modification in platelets, and the glycosylation pattern is critical for platelet function. To date, the exploration of the roles of various glycoforms in specific platelet functions is largely lacking. In this study, a global analysis of intact N-glycopeptides in human platelets was performed to map all the glycopeptides, glycosites and glycans of platelets.

Understanding the behavioral intentions of MaaS during public health events.

Introduction: Mobility as a Service (MaaS) integrates various modes of transportation, provides personalized travel services for travelers, and improves the efficiency of traditional travel modes. To examine the mechanisms underlying the impact of sudden public health events on the behavioral intentions to use MaaS and provide theoretical support for the sustainable development of MaaS, this research investigates the Beijing MaaS program as a case.

Methods: A total of 630 questionnaires were collected.

Effects of storage on volatile organic components and physiological properties of different storage-tolerant rice varieties.

The effects of storage on rice flavor among different rice varieties have not been well studied. To address this gap, we analyzed volatile organic components (VOCs) identified by gas chromatography-ion mobility spectrometry (GC-IMS) and related physicochemical properties of different storage-tolerant rice varieties during storage. The results showed that VOCs of four rice varieties significantly changed after 6 months of storage; OPLS-DA analysis classified the four rice varieties into two groups.

Mitigation of Polysulfide Shuttling in Lithium-Sulfur Batteries Utilizing Vanadium Pentoxide/Polypyrrole Nanocomposite Separators.

Lithium-sulfur (Li-S) batteries are promising energy storage devices due to their high theoretical energy density and cost-effectiveness. However, the shuttle effect of polysulfides during the charging and discharging processes leads to a rapid decline in capacity, thereby restricting their application in energy storage. The separator, a crucial component of Li-S batteries, facilitates the transport of Li ions.

Triple circularly polarized luminescence of phenylalanine-based supramolecular gels regulated by kinetic and thermodynamic assembly pathways.

A single phenylalanine-based gelator can self-assemble into various chiral nanostructures with triple circularly polarized luminescence (CPL). Its supramolecular assembly and CPL emission are found to be dependent on the kinetic and thermodynamic pathways. This work provides new insight into the regulation of CPL-active functional materials.

Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis.

Introduction: Amyotrophic lateral sclerosis (ALS) is a rare, devastating neurodegenerative disease that affects upper and lower motor neurons, resulting in muscle atrophy, spasticity, hyperreflexia, and paralysis. Inflammation plays an important role in the development of ALS, and associated with rapid disease progression. Current observational studies indicate the thinning of cortical thickness in patients with ALS is associated with rapid disease progression and cognitive changes.

Multiphase Radical Chemical Processes Induced by Air Pollutants and the Associated Health Effects.

Air pollution is increasingly recognized as a significant health risk, yet our understanding of its underlying chemical and physiological mechanisms remains incomplete. Fine particulate matter (PM) and ozone (O) interact with biomolecules in intracellular and microenvironments, such as the epithelial lining fluid (ELF), leading to the generation of reactive oxygen species (ROS). These ROS trigger cellular inflammatory responses and oxidative stress, contributing to a spectrum of diseases affecting the respiratory, cardiovascular, and central nervous systems.

Quantum Dot Luminescence Microspheres Enable Ultra-Efficient and Bright Micro-LEDs.

Quantum dot (QD)-converted micrometer-scale light-emitting diodes (micro-LEDs) are regarded as an effective solution for achieving high-performance full-color micro-LED displays because of their narrow-band emission, simplified mass transfer, facile drive circuits, and low cost. However, these micro-LEDs suffer from significant blue light leakage and unsatisfactory electroluminescence properties due to the poor light conversion efficiency and stability of the QDs. Herein, the construction of green and red QD luminescence microspheres with the simultaneously high conversion efficiency of blue light and strong photoluminescence stability are proposed.

Autism screening tool validation for toddlers and young children: advantages and limitations.

Background: Early identification is crucial for children with autism. However, many children are diagnosed later due to the lack of specific assessment tools in primary care settings. The study aims to evaluate the effectiveness of the STAT in screening autism across different age groups while assessing its advantages and limitations.

Ultrasensitive Xe Magnetic Resonance Imaging: From Clinical Monitoring to Molecular Sensing.

Magnetic resonance imaging (MRI) is a cornerstone technology in clinical diagnostics and in vivo research, offering unparalleled visualization capabilities. Despite significant advancements in the past century, traditional H MRI still faces sensitivity limitations that hinder its further development. To overcome this challenge, hyperpolarization methods have been introduced, disrupting the thermal equilibrium of nuclear spins and leading to an increased proportion of hyperpolarized spins, thereby enhancing sensitivity by hundreds to tens of thousands of times.

Dopamine Drives Feedforward Inhibition to Orexin Feeding System, Mediating Weight Loss Induced by Morphine Addiction.

Feeding behavior changes induced by opioid addiction significantly contribute to the worsening opioid crisis. Activation of the reward system has shown to provoke binge eating disorder in individuals with opioid use disorder, whereas prolonged opioid exposure leads to weight loss. Understanding the mechanisms underlying these phenomena is essential for addressing this pressing societal issue.

Spin Magnetic Effect Activate Dual Site Intramolecular O─O Bridging for Nickel-Iron Hydroxide Enhanced Oxygen Evolution Catalysis.

The oxygen evolution reaction (OER) involves the recombination of diamagnetic hydroxyl (OH) or water (HO) into the paramagnetic triplet state of oxygen (O). The spin conservation of oxygen intermediates plays a crucial role in OER, however, research on spin dynamics during the catalytic process remains in its early stages. Herein, β-Ni(OH) and Fe-doped β-Ni(OH) (NiFe(OH)) are utilized as model catalysts to understand the mechanism of spin magnetic effects at iron (III) sites during OER.

Effects of upper extremity blood flow restriction training on muscle strength and hypertrophy: a systematic review and meta-analysis.

Background: Low load resistance training with blood flow restriction (LL-BFRT) has been shown to improve muscle strength and hypertrophic function. The effect of LL-BFRT on lower extremity muscle improvement has been widely discussed. However, no studies have discussed the effect of this training method on the upper extremity muscles until now.

Identification of Different Steaming Degrees of Panax quinquefolius L. Based on GC-IMS Combined With Machine Learning.

Rationale: Panax quinquefolius L. (PQ), a commonly used traditional Chinese medicine and a food, is usually processed into various products, including white PQ, red PQ (two- or three-time steamed PQ), and black PQ (nine-time steamed PQ). Previous studies demonstrated that volatile components (VOCs) were the important active substances of PQ, which had antibacterial, antiviral, and anti-leukemia activities.

"Cu-N" Site-Driven Selectivity Switch for Electrocatalytic CO Reduction.

The comprehensive understanding of the effect of the chemical environment surrounding active sites on the pathway for the electrochemical carbon dioxide reduction reaction (eCORR) is essential for the development of advanced catalysts for large-scale applications. Based on a series of model catalysts engineered by the coordination of copper ions with various isomers of phenylenediamine [i.e.

Modification at ITO/NiO Interface with MoS Enables Hole Transport for Efficient and Stable Inverted Perovskite Solar Cells.

Inverted perovskite solar cells (IPSCs) utilizing nickel oxide (NiO) as hole transport material have made great progress, driven by improvements in materials and interface engineering. However, challenges remain due to the low intrinsic conductivity of NiO and inefficient hole transport. In this study, we introduced MoS nanoparticles at the indium tin oxide (ITO) /NiO interface to enhance the ITO surface and optimize the deposition of NiO, resulting in increased conductivity linked to a ratio of Ni:Ni.

A modern scientific perspective on the flavor and functional properties of diverse teas in traditional cuisine "tea-flavored fish": From macroscopic quality to microscopic variations.

The historical appreciation of tea dates back to ancient times, while technological limitations have long hindered in-depth exploration of its flavor complexity and functional attributes. This study investigated the effects of various teas on a traditional delicacy, "tea-flavored fish", using teas processed via traditional methods. Analysis of functional components revealed that processing and fermentation reduced catechin levels (186.

Global research trends on nanotechnology and colorectal cancer: a two-decade analysis.

Introduction: Colorectal cancer (CRC) remains a serious threat to humans worldwide. In this study, we used bibliometric analysis of the scientific literature to assess the trends and prospects of nanotechnology applications in CRC.

Materials And Methods: We used the Web of Science Core Collection database to screen relevant publications on nanotechnology and CRC from 2004 to 2023 based on the inclusion criteria.

Hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity syndrome after brain injury: a multicenter, retrospective cohort study.

Hyperbaric oxygen has been used to treat many diseases. However, there are few reports on hyperbaric oxygen treatment for paroxysmal sympathetic hyperactivity at home and abroad, and the clinical experience is very limited. To understand the efficacy of hyperbaric oxygen treatment for paroxysmal sympathetic hyperactivity after brain injury, this retrospective study was conducted in the adult intensive care units of five medical centers in central China.

Serum magnesium, not calcium, is inversely associated with abnormal HbA1c concentrations in adults with coronary artery disease.

Background And Objectives: Mechanism studies have indicated that magnesium (Mg) and calcium (Ca) have important biological functions in glucose regulation, but epidemiological data on their associations with glycosylated hemoglobin (HbA1c) are sparse. We aimed to explore the associations of Mg and Ca with abnormal HbA1c, and examine the mediating effects of inflammation in coronary artery disease (CAD) Chinese adults.

Methods And Study Design: A hospital-based cross-sectional study of 11934 patients with CAD was conducted.

The multifaceted roles of macrophages in the transition from hepatitis to hepatocellular carcinoma: From mechanisms to therapeutic strategies.

Macrophages are central to the progression from hepatitis to hepatocellular carcinoma (HCC), with their remarkable plasticity and ability to adapt to the changing liver microenvironment. Chronic inflammation, fibrosis, and ultimately tumorigenesis are driven by macrophage activation, making them key regulators of liver disease progression. This review explores the diverse roles of macrophages in the transition from hepatitis to HCC.

Post-transcriptional and post-translational regulation of anthocyanin biosynthesis in sweetpotato by Ib-miR2111 and IbKFB: Implications for health promotion.

Introduction: Sweetpotato (Ipomoea batatas (L.) Lam.) is a genetically intricate hexaploid crop.

Mechanical and microscopic characterization of expansive soils modified by water-soluble polymers.

With the advancement of ecological and environmental protection construction, the research on the modification of expansive soil using environmentally friendly polymers can make up for the harm to the ecological environment caused by traditional modification. Mechanical and microscopic properties of modified expansive soils were analyzed through indoor tests. The results showed that the liquid limit and plasticity index decreased by 52.