A Machine Learning Model to Predict Risk for Hepatocellular Carcinoma in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.

Background And Aims: Hepatocellular carcinoma (HCC) incidence is increasing and correlated with metabolic dysfunction-associated steatotic liver disease (MASLD; formerly nonalcoholic fatty liver disease), even in patients without advanced liver fibrosis who are more likely to be diagnosed with advanced disease stages and shorter survival time, and less likely to receive a liver transplant. Machine learning (ML) tools can characterize large datasets and help develop predictive models that can calculate individual HCC risk and guide selective screening and risk mitigation strategies.

Methods: Tableau and KNIME Analytics were used for descriptive analytics and ML tasks.

Dissecting chickpea genomic loci associated with the root penetration responsive traits in compacted soil.

Soil compaction reduces root exploration in chickpea. We found genes related to root architectural traits in chickpea that can help understand and improve root growth in compacted soils. Soil compaction is a major concern for modern agriculture, as it constrains plant root growth, leading to reduced resource acquisition.

Additive fabrication and experimental validation of a lightweight thermoelectric generator.

We develop a thermoelectric generator based on catalytic combustion and operating in the low power range (up to 10 W). Considering the target of small-scale thermoelectric generators, the additive technique was chosen as an enabling technology to customize the different parts of the presented device. The generator consists of a hexagonal shaped combustion chamber coupled to commercial thermoelectric modules, water-cooled at the cold side.

A double pulse LII experiment on carbon nanoparticles: insight into optical properties.

In this work cooled carbon nanoparticles are investigated with the aim of gaining knowledge on their properties. To this purpose, a double pulse experiment is employed consisting essentially of a modified Laser-Induced Incandescence (LII) approach. Before the conventional LII measurements, nanoparticles are additionally irradiated applying different laser fluences.

Cobalt Oxide Synthesis via Flame Spray Pyrolysis as Anode Electrocatalyst for Alkaline Membrane Water Electrolyzer.

Nanostructured cobalt oxide powders as electro catalysts for the oxygen evolution reaction (OER) in an alkaline membrane electrolysis cell (AME) were prepared by flame spray synthesis (FS); an AME's anode was then produced by depositing the FS prepared cobalt oxide powders on an AISI-316 sintered metal fiber by the electrophoretic deposition (EPD) method. FS powders and the composite electrode were characterized by SEM, XRD, and XPS analysis. The electrode showed an increase in the OER catalytic activity in a KOH 0.

In-flow optical characterization of flame-generated carbon nanoparticles sampled from a premixed flame.

In this work, the optical absorption properties of carbon nanoparticles are investigated by applying in-flow extinction and laser-induced incandescence measurements. Carbon nanoparticles are produced in an ethylene/air premixed flame and sampled at different heights above the burner. From extinction measurements, the absorption coefficient is obtained in a wide spectral range, considering the negligible scattering under our experimental conditions.

Effect of Laser Irradiation on Emissivity of Flame-Generated Nanooxides.

The application of pyrometry to retrieve particle temperature in particulate-generating flames strictly requires the knowledge of the spectral behavior of emissivity of light-emitting particles. Normally, this spectral behavior is considered time-independent. The current paper challenges this assumption and explains why the emissivity of oxide nanoparticles formed in flame can change with time.

Genetic relationship, population structure analysis and pheno-molecular characterization of rice ( L.) cultivars for bacterial leaf blight resistance and submergence tolerance using trait specific STS markers.

Unlabelled: Rice is an important source of calorie for the growing world population. Its productivity, however is affected by climatic adversities, pest attacks, diseases of bacterial, viral and fungal origin and many other threats. Developing cultivars that are high yielding and stress resilient seems a better solution to tackle global food security issues.

Identification of QTLs for high grain yield and component traits in new plant types of rice.

A panel of 60 genotypes comprising New Plant Types (NPTs) along with indica, tropical and temperate japonica genotypes was phenotypically evaluated for four seasons in irrigated situation for grain yield per se and component traits. Twenty NPT genotypes were found promising with an average grain yield varying from 5.45 to 8.

Marker-assisted selection for grain number and yield-related traits of rice ( L.).

Continuous rise in the human population has resulted in an upsurge in food demand, which in turn demand grain yield enhancement of cereal crops, including rice. Rice yield is estimated via the number of tillers, grain number per panicles, and the number of spikes present per panicle. Marker-assisted selection (MAS) serve as one of the best ways to introduce QTLs/gene associated with yield in the rice plant.

In silico characterization of the impact of mutation (LEU112PRO) on the structure and function of carotenoid cleavage dioxygenase 8 in Oryza sativa.

Mutation (p.LEU112PRO) in "carotenoid cleavage dioxygenase 8" (CCD8) protein increases tiller formation in rice plants by cross-talking with auxin and cytokinins. However, owing to the nonexistence of a "three-dimension" structure of CCD8, detail information about its structure and function remain elusive until date.

approaches to detect inhibitors of the human severe acute respiratory syndrome coronavirus envelope protein ion channel.

Recent outbreak of Coronavirus disease (COVID-19) pandemic around the world is associated with 'severe acute respiratory syndrome' (SARS-CoV2) in humans. SARS-CoV2 is an enveloped virus and E proteins present in them are reported to form ion channels, which is mainly associated with pathogenesis. Thus, there is always a quest to inhibit these ion channels, which in turn may help in controlling diseases caused by SARS-CoV2 in humans.

Characterization of haplotypes and single nucleotide polymorphisms associated with Gn1a for high grain number formation in rice plant.

Rice serves as one of the essential staple food for half of the global human population. However, due to rapid human population growth, there is an increase in food demand across the globe. Thus, to lessen the gap between food demand and supply, there is an urgent requirement for grain yield enhancement in various important cereals crops, including rice.

Computational characterization of structural and functional roles of DREB1A, DREB1B and DREB1C in enhancing cold tolerance in rice plant.

Rice serves as the major food for almost half of the world population. Because of its origin in the tropical and subtropical area, rice is more sensitive towards cold stress. Three homologs of DREB1, namely DREB1A, DREB1B and DREB1C are induced Queryduring cold stress and after binding with GCC-box in the promoter region of the target gene, they enhance cold tolerance in rice plants.

Computational approach towards understanding structural and functional role of cytokinin oxidase/dehydrogenase 2 (CKX2) in enhancing grain yield in rice plant.

Cytokinin oxidase/dehydrogenase (CKX) is the only known enzyme associated with irreversible degradation of cytokinins in plants. CKX2 contains flavin adenine dinucleotide (FAD) domain. Earlier studies utilising antisense & hpRNAi suppression techniques in mutant/transgenic rice plants revealed that when CKX2 binds with FAD, CKX2 expression reduces, which in turn causes cytokinin aggregation in inflorescence meristem that subsequently enhances both branches and grain number resulting in increased grain yield.

Computational approach to understand molecular mechanism involved in BPH resistance in Bt- rice plant.

In silico approach was utilised to identify differentially expressed key hub genes during BPH infestation on Bt rice plant, under laboratory conditions. Re-analysis of GSE74745 data with in-house R scripts and STRING database reveals that only 5 key hub genes, namely Os05g0176100, Os06g0683200, Os07g0208500, Os07g0252400 and Os07g0424400, belonging to cellulose synthase family, are differentially expressed and have confidence score ≥0.9 among themselves.

Study of the Performances of a Thermoelectric Generator Based on a Catalytic Meso-Scale H₂/C₃H₈ Fueled Combustor.

In this work the thermoelectric generator (TEG) based on catalytic combustion already developed in our lab has been further investigated and improved. The system made of two thermoelectric (TE) modules coupled with a catalytic combustor has been used in this work to obtain higher overall efficiency by adding hydrogen to the fuel mixture. Since implementation of hydrogen as a fuel has shown low and stable combustion temperature in literature, it is expected to achieve good overall efficiency of TEG.

Insights into the structure-function relationship of brown plant hopper resistance protein, Bph14 of rice plant: a computational structural biology approach.

Brown plant hopper (BPH) is one of the major destructive insect pests of rice, causing severe yield loss. Thirty-two BPH resistance genes have been identified in cultivated and wild species of rice Although, molecular mechanism of rice plant resistance against BPH studied through map-based cloning, due to non-existence of NMR/crystal structures of Bph14 protein, recognition of leucine-rich repeat (LRR) domain and its interaction with different ligands are poorly understood. Thus, in the present study, in silico approach was adopted to predict three-dimensional structure of LRR domain of Bph14 using comparative modelling approach followed by interaction study with jasmonic and salicylic acids.

Laser-Induced Breakdown Spectroscopy Analysis of Lead Aerosol in Nitrogen and Air Atmosphere.

In this work, laser-induced breakdown spectroscopy (LIBS) is applied for quantitative measurements of Pb in aerosols. In order to investigate the carrier gas role and, in particular, the effect of O addition to the gas itself, measurements are carried out in nitrogen and air atmosphere. Aerosol particles are produced by nebulizing Pb(CHCOO) * 3HO aqueous solutions of known concentration and the atomic line of 405.

Pigmented villonodular synovitis. A follow-up study.

Pigmented villonodular synovitis (PVS) was diagnosed in 25 patients during the period 1950--76. Twenty-two of the patients were re-examined 2--28 years later. Three patients with local affection of tendon sheaths, treated by excision, were all free of symptoms at follow-up.

A double-blind study comparing sulindac with indomethacin in rheumatoid arthritis.

Forty-two patients with definite or classical rheumatoid arthritis were included in a 6-week double-blind study to compare sulindac with indomethacin. Patients were randomly assigned to therapy, either sulindac 100 mg b.i.

Persistent local cutaneous atrophy following corticosteroid injection for tendinitis.

A 21-year-old female, treated with triamcinolone for tendinitis in the oblique muscles of both forearms, developed a skin atrophy, localized around the injection points. The patient was followed over a period of more than five years during which a partial remission of the skin changes was observed. A synopsis covering local use of steroids for various diseases is given.