Publications by authors named "Donatella Tansella"

Heart failure (HF) remains a critical global health challenge, necessitating advancements in diagnostic and therapeutic strategies. This review explores the evolution of imaging technologies and their impact on HF management, focusing on three-dimensional echocardiography (3DE), myocardial strain imaging, and vortex dynamics imaging. Three-dimensional echocardiography enhances traditional echocardiography by providing more accurate assessments of cardiac structures, while myocardial strain imaging offers the early detection of subclinical myocardial dysfunction, crucial in conditions such as chemotherapy-induced cardiotoxicity and ischemic heart disease.

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Coronary artery disease (CAD) is the leading global cause of mortality, accounting for approximately 30% of all deaths. It is primarily characterized by the accumulation of atherosclerotic plaques within the coronary arteries, leading to reduced blood flow to the heart muscle. Early detection of atherosclerotic plaques is crucial to prevent major adverse cardiac events.

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Article Synopsis
  • - The study examined the link between specific autoantibodies (AT1R-AAs and ETAR-AAs) and left ventricular remodeling (LVR) in patients who experienced a myocardial infarction (heart attack), highlighting how these antibodies affect treatment outcomes.
  • - Conducted on 131 patients treated for ST-segment-elevation myocardial infarction, researchers found a significant prevalence of these autoantibodies in those who developed LVR, with 39% of patients with LVR being seropositive for AT1R-AAs.
  • - The findings indicate that AT1R-AAs not only correlate with LVR but also serve as a risk factor for future serious heart-related events, suggesting potential targets for improving
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Aims: Spontaneous coronary artery dissection (SCAD) is an uncommon cause of acute myocardial infarction in women and has an unclear pathophysiology. Autoantibodies (AAs) targeting angiotensin-II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) have known detrimental effects on endothelial function. We investigated the prevalence of these AAs in SCAD-affected female patients.

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