Toward Origami-Inspired In Vitro Cardiac Tissue Models.

The advancement of engineered cardiac tissue-based patches is paramount for providing viable solutions for restoring cardiac function through implantation. Numerous techniques described in the literature aim to provide diverse mechanical and topographical cues simultaneously, fostering enhanced cardiac maturation and functionality. Among these, cellulose paper-based scaffolds have gained attention owing to their inherent benefits, such as biocompatibility and ease of chemical and physical modification.