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Publications by authors named "Donald S Karanewsky"

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Synopsis of recent research by authors named "Donald S Karanewsky"

  • - Donald S. Karanewsky's recent research predominantly focuses on the role of mitochondrial protease ClpP and its potential as a therapeutic target in cancer treatments, particularly for chronic lymphocytic leukemia (CLL) and other malignancies resistant to conventional therapies.
  • - His work highlights the effectiveness of imipridone compounds, such as TR-57 and ONC-212, which act as ClpP activators and show promising results in combination therapies for enhancing cell death in drug-resistant cancer cells.
  • - Karanewsky's studies also include the discovery and characterization of new small-molecule ClpP agonists, emphasizing their ability to selectively inhibit cancer growth and alter mitochondrial protein quality control mechanisms, offering insights into innovative cancer treatment strategies.

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