Publications by authors named "Donald Ranft"
Periprosthetic joint infections (PJI) are serious complications after arthroplasty, associated with high morbidity, mortality, and complex treatment processes. The outcomes of different PJI entities are largely unknown. The aim of this study was to access the early outcomes of different PJI entities.
View Article and Find Full Text PDFBackground: Institution-specific guidelines (ISGs) within the framework of antimicrobial stewardship programs offer locally tailored decision support taking into account local pathogen and resistance epidemiology as well as national and international guidelines.
Objectives: To assess the impact of ISGs for antimicrobial therapy on antibiotic consumption and subsequent changes in resistance rates and Clostridioides difficile infections (CDIs).
Methods: The study was conducted at the Leipzig University Hospital, a 1,451-bed tertiary-care medical center, and covered the years 2012 to 2020.
Aim: To evaluate recommendations of an antibiotic stewardship (ABS) team during routine weekly visits and to analyse their implementation and reasons for non-implementation by the ward physicians.
Methods: Multiprofessional ABS Rounds (members: infectiology, microbiology, pharmacy and hospital epidemiology) were accompanied by an observer in nine intensive and peripheral wards of a university hospital (1451 beds) for eight weeks. The recommendations of the ABS team were prospectively analysed, and when these were not implemented, ward physicians in charge were asked to give reasons for non-implementation.
Article Synopsis
- * Methods: Conducted in a large academic medical center in Germany, the research involved a structured electronic survey sent to doctors, with data collected on the use and effectiveness of ISGs presented in various formats (print, PDF, app).
- * Results: Out of 914 contacted doctors, 282 responded, showing that ISGs were frequently used and highly regarded for their ease of use, especially by younger clinicians. Notably, a significant percentage reported behavioral changes in their prescribing practices after using the guidelines, with app users
Article Synopsis
- The study examined infection rates of Clostridium difficile (CDI) at Leipzig University Hospital from 2013 to 2019, using multivariate linear regression analysis.
- Ceftriaxone was identified as the only independent predictor for the incidence of CDI, indicating a significant link between its use and infection rates.
- The research highlights the importance of understanding the pharmacokinetic and pharmacodynamic properties of antibiotics, particularly ceftriaxone's biliary excretion, when evaluating their risk of promoting CDI.