A randomized control trial of high-dose micronutrient-antioxidant supplementation in healthy persons with untreated HIV infection.

Background: Although micronutrient and antioxidant supplementation are widely used by persons with human immunodeficiency virus (HIV), a therapeutic role beyond recommended daily allowances (RDA) remains unproven. An oral high-dose micronutrient and antioxidant supplement (Treatment) was compared to an RDA supplement (Control) for time to progressive immunodeficiency or initiation of antiretroviral therapy (ART) in people living with HIV (PLWH).

Methods: This study was a randomized, double-blind, placebo-controlled multicenter clinical trial.

Challenges in initiating antiretroviral therapy in 2010.

Many clinical trials have shown that initiating antiretroviral therapy (ART) at higher rather than lower CD4 T cell-positive counts results in survival benefit. Early treatment can help prevent end-organ damage associated with HIV replication and can decrease infectivity. The mainstay of treatment is either a non-nucleoside reverse transcriptase inhibitor or a ritonavir-boosted protease inhibitor in combination with two nucleoside reverse transcriptase inhibitors.

Cardiovascular and thermal responses to repeated head-up tilts following exercise-induced heat stress.

Background: We evaluated the acute cardiovascular and thermoregulatory responses to repeated 70 degrees head-up tilts (HUT) performed following exercise-induced hyperthermia.

Methods: Eight male subjects underwent intermittent episodes of 70 degrees HUT in either a non-exercise/ non-heat stress state (NH) or an exercise-induced hyperthermic state (EIH). Subjects remained supine for 30 min in a thermoneutral environment (22 degrees C) and were subsequently exposed to three successive 6-min 70 degrees head-up tilts (HUT1, HUT2, HUT3), each separated by 10 min of supine resting.

Influence of nonthermal baroreceptor modulation of heat loss responses during uncompensable heat stress.

We evaluated the hypothesis that with increasing levels of hyperthermia, thermal influences would predominate over nonthermal baroreceptor control of cutaneous vascular conductance (CVC) and local sweat rate (LSR). On separate days, eight male participants were positioned in either an upright seated posture (URS) or a 15 degrees head-down tilt (HDT) posture in a thermoneutral condition and during passive heating, until mean body temperature (T(body)) increased by 1.5 degrees C.

Menstrual cycle and oral contraceptive use do not modify postexercise heat loss responses.

It is unknown whether menstrual cycle or oral contraceptive (OC) use influences nonthermal control of postexercise heat loss responses. We evaluated the effect of menstrual cycle and OC use on the activation of heat loss responses during a passive heating protocol performed pre- and postexercise. Women without OC (n = 8) underwent pre- and postexercise passive heating during the early follicular phase (FP) and midluteal phase (LP).