Publications by authors named "Donald E"

Introduction: Effective communication and understanding are imperative for heart transplant (HT) recipients who require lifelong adherence to treatment plans and medications. Whether non-native English speaking (NNES) recipients have inferior outcomes compared to native English-speaking recipients (NES) has not been studied post-HT.

Methods: We reviewed adult HT recipients at Columbia University Irving Medical Center from January 2005 through December 2022 with primary language determined by chart review.

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The evolution of bipedal gait is a key adaptive feature in hominids, but the running abilities of early hominins have not been extensively studied. Here, we present physics simulations of Australopithecus afarensis that demonstrate this genus was mechanically capable of bipedal running but with absolute and relative (size-normalized) maximum speeds considerably inferior to modern humans. Simulations predicted running energetics for Australopithecus that are generally consistent with values for mammals and birds of similar body size, therefore suggesting relatively low cost of transport across a limited speed range.

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Background: Cardiac allograft vasculopathy (CAV) leads to impaired myocardial blood flow (MBF), increasing the risk of cardiovascular death or retransplant among heart transplantation (HT) recipients. Data on elevation in donor-derived cell-free DNA (dd-cfDNA) and CAV in the absence of rejection are mixed. We sought to test the hypothesis that CAV with reduced MBF (RMBF) is associated with elevated dd-cfDNA.

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The Europa Imaging System (EIS) consists of a Narrow-Angle Camera (NAC) and a Wide-Angle Camera (WAC) that are designed to work together to address high-priority science objectives regarding Europa's geology, composition, and the nature of its ice shell. EIS accommodates variable geometry and illumination during rapid, low-altitude flybys with both framing and pushbroom imaging capability using rapid-readout, 8-megapixel (4k × 2k) detectors. Color observations are acquired using pushbroom imaging with up to six broadband filters.

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  • Women are under-represented in academic cardiology publishing, and implementing double-blind peer reviews is thought to help reduce gender bias in authorship.
  • The Journal of Cardiac Failure switched to double-blind reviews in July 2021 and studied changes in author demographics over three time periods from 2021 to 2023.
  • The analysis revealed a rise in female first authors from 24% to 39%, indicating that double-blind reviews might enhance gender diversity in authorship, while senior authorship by women remained consistent.
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  • - A 70-year-old man with a history of atrial flutter was hospitalized for symptoms and imaging suggesting an acute stroke, including a slow pulse and facial weakness.
  • - His ECG revealed a unique type of bradycardia indicating issues with his heart's electrical system, likely connected to the stroke.
  • - After monitoring, he regained a normal heart rhythm and didn't experience any further arrhythmias during his hospital stay.
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  • More women of childbearing age are surviving heart transplants and many wish to become pregnant, but there's little information on their counseling experiences or knowledge regarding pregnancy after transplantation.
  • A survey of 64 women who underwent heart transplants revealed that many felt they lacked adequate information about post-transplant pregnancy and contraception before and after the procedure.
  • The results indicate a significant gap in communication between healthcare providers and these women, suggesting a need for improved education and support regarding reproductive health after heart transplantation.*
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  • The study examined the effects of glucagon-like-peptide 1 receptor agonists (GLP1-RA) on heart transplant recipients dealing with diabetes and obesity, as there has been limited research in this area.
  • A total of 74 patients were analyzed, with significant improvements in cardiometabolic parameters such as reduced BMI, lower blood sugar levels (HbA1C), and decreased LDL cholesterol after using GLP1-RA for around 383 days.
  • Results indicated that GLP1-RA therapy was effective in managing diabetes and weight in these patients, with minimal impact on their immunosuppression medication adjustments.
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Introduction: Over the past two decades, Tanzania's burden of non-communicable diseases has grown disproportionately, but limited resources are still prioritized. A trained human resource for health is urgently needed to combat these diseases. However, continuous medical education for NCDs is scarce.

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  • This study explores the challenges faced by pediatric heart transplant (HT) recipients when transitioning to adult care, focusing on identifying risk factors for poor health outcomes.
  • Researchers analyzed data from 72 patients who made this transition between 2011 and 2021, noting key factors such as medication adherence, psychiatric history, and age at transition.
  • The findings emphasize the need for structured transition plans tailored to high-risk individuals to improve adherence and outcomes in adult HT care.
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Person-centredness is a cornerstone to a palliative approach to care. However, there is a risk that a person-centred perspective is lost in how a palliative approach is evaluated. We explored the extent to which evaluations of a palliative approach are consistent with its person-centred ethical stance.

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  • * The focus on acute management in healthcare systems is affecting the ability of these clients to receive the support they need, which is especially important for those wishing to die at home.
  • * The study emphasizes the need to reconsider how these shifts in homecare practices impact families and clients, especially in relation to palliative care principles.
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Cadaveric anatomy is frequently described as the gold standard for anatomy education. Increasingly and especially following the COVID-19 pandemic, there is acceptance that a blended approach for anatomy curriculum delivery is optimal for learners.Setting up a new UK Medical School in 2019 necessitated building a new cadaveric anatomy facility.

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  • Up to 10% of heart transplant patients may require permanent pacemakers (PPMs), with this study focusing on the long-term outcomes of those who did.
  • Out of 1,082 heart transplant recipients studied, 41 (3.8%) needed PPMs mainly due to sinus node dysfunction and AV nodal disease, experiencing few complications.
  • Notably, PPM implantations decreased after 2018, suggesting a shift towards more cautious management in the early postoperative period, with no significant differences in mortality or re-transplantation rates among patients with and without PPMs.
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  • Historically, women have faced disparities in access to heart transplantation and have had worse outcomes compared to men, prompting a study to assess improvements in sex differences under the 2018 allocation system.* -
  • The study analyzed data from over 15,000 adult patients listed for heart transplantation, revealing that while women had lower priority statuses and less use of some mechanical support compared to men, they had a higher cumulative incidence of transplantation within six months under the new allocation system.* -
  • Despite the continued lower use of temporary mechanical support for women, changes in the allocation system show an improvement in their outcomes, including a significant increase in the distance traveled for organ procurement.*
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Introduction: People who experience social disadvantage including homelessness suffer from numerous ill health effects when compared to the general public. Use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs) enables collection of information from the point of view of the person receiving care. Involvement in research and health care decision-making, a process that can be facilitated by the use of PROMs and PREMs, is one way to promote equity in care.

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There is limited research on the biomechanical assessment of the lower limb joints in relation to dynamic movements that occur at the hip, knee, and ankle joints when performing dorsiflexion (DF) and plantarflexion (PF) among males and females. This study investigated the differences in joint angles (including range of motion (ROM)) and forces (including moments) between the left and right limbs at the ankle, knee, and hip joints during dynamic DF and PF movements in both males and females. Using a general linear model employing multivariate analysis in relation to the joint angle, ROM, force, and moment datasets, the results revealed significant main effects for gender, sidedness, phases, and foot position with respect to joint angles.

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Our patient presented in her third trimester of pregnancy with new onset of heart failure. A thorough workup in the initial postpartum period with detailed past medical history, advanced imaging modalities, and a multidisciplinary approach revealed a rare and treatable etiology of cardiomyopathy. ().

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