Publications by authors named "Donal Mealey"
Article Synopsis
- The study investigates how fenoxycarb molecules interact and aggregate in isopropanol solutions using several analytical techniques like dynamic light scattering and infrared spectroscopy.
- Clusters of molecules can grow up to almost one micrometre in size and tend to increase in size with higher solute concentrations and longer time periods under stagnant conditions.
- The research also notes that factors like temperature, filtration, and concentration levels significantly affect cluster sizes and their behavior, pointing to complex dynamics in solution that influence molecular interactions.
Over 2100 induction time experiments were carried out for the medium-sized, antipsychotic drug molecule, risperidone in seven different organic solvents. To reach the same induction time the required driving force increases in the order: cumene, toluene, acetone, ethyl acetate, methanol, propanol, and butanol, which reasonably well correlates to the interfacial energies as determined within classical nucleation theory. FTIR spectroscopy has been used to investigate any shifts in the spectra and to estimate the interaction of solute and solvent at the corresponding site.
View Article and Find Full Text PDFIn previous work, it has been shown that the crystal nucleation of salicylic acid (SA) in different solvents becomes increasingly more difficult in the order: chloroform, ethyl acetate acetonitrile, acetone, methanol, and acetic acid. In the present work, vibration spectroscopy, calorimetric measurements, and density functional theory (DFT) calculations are used to reveal the underlying molecular mechanisms. Raman and infrared spectra suggest that SA exists predominately as dimers in chloroform, but in the other five solvents there is no clear evidence of dimerization.
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