Lack of significant interactions between clopidogrel and proton pump inhibitor therapy: meta-analysis of existing literature.

Background: Published data regarding the effect of concomitant clopidogrel and proton pump inhibitor (PPI) therapy on cardiovascular outcomes have been conflicting.

Aim: To perform an updated meta-analysis in order to determine changes in risk differences (RD) between primary and secondary outcome analyses.

Methods: Primary analysis was based on definite vascular outcomes, including all cause mortality, cardiac death, myocardial infarction, and/or stroke.

Systematic review: benefits and harms of in-hospital use of recombinant factor VIIa for off-label indications.

Background: Recombinant factor VIIa (rFVIIa), a hemostatic agent approved for hemophilia, is increasingly used for off-label indications.

Purpose: To evaluate the benefits and harms of rFVIIa use for 5 off-label, in-hospital indications: intracranial hemorrhage, cardiac surgery, trauma, liver transplantation, and prostatectomy.

Data Sources: Ten databases (including PubMed, EMBASE, and the Cochrane Library) queried from inception through December 2010.

Three-port versus four-port laparoscopic cholecystectomy in acute and chronic cholecystitis.

Background: Several modifications have been introduced to laparoscopic cholecystectomy (LC). The three-port technique has been practiced on a limited scale. Our aim was to compare the three-port and four-port LC in acute (AC) and chronic cholecystitis (CC).

The diagnosis of acute cholecystitis in patients undergoing early laparoscopic cholecystectomy in a community hospital.

Background: Early laparoscopic cholesyctectomy is the procedure of choice for acute cholecystitis; however, the diagnosis of acute cholecystitis in a community hospital setting is not always a simple matter.

Methods: A retrospective review of 70 patients who have been admitted through the A&E department with the symptomatic gall bladder stones between July 2002 and May 2003.

Results: To diagnose acute cholecystitis, as a single test, the sensitivity and the predictive value of the clinical-based diagnosis were 72.