Publications by authors named "Donado K"
Background And Objective: Sensitization to Blomia tropicalis is associated with asthma in various tropical and subtropical countries; however, information about the specific molecular components associated with this disease is scarce. Using molecular diagnosis, we sought to identify B tropicalis allergens associated with asthma in Colombia.
Methods: Specific IgE (sIgE) to 8 B tropicalis recombinant allergens (Blo t 2, 5, 7, 8, 10, 12, 13, and 21) was determined using an in-house ELISA system in asthma patients (n=272) and controls (n=298) recruited in a national prevalence study performed in several Colombian cities (Barranquilla, Bogotá, Medellín, Cali, and San Andrés).
Article Synopsis
- - The study focused on evaluating the allergenic properties of Blo t 2, a specific allergen from house dust mites, using both human and mouse models to assess its effects.
- - Results showed that sensitivity to Blo t 2 was comparable to another allergen, Blo t 21, but higher than Der p 2, with most patients having a low-intensity allergic response.
- - Immunization of mice with Blo t 2 led to significant allergic reactions, including skin inflammation and lung issues, confirming its allergenic activity and importance in clinical settings.