Chiral Self-Assembly of a Pyrene-Appended Glutamylalanine Dipeptide and Its Charge Transfer Complex: Fabrication of Magneto-Responsive Hydrogels and Human Cell Imaging.

The formation of a robust, self-healing hydrogel of a novel pyrene-appended dipeptide, Py-E-A (L-Glutamic acid short as E; L-Alanine short as A) is demonstrated. Detailed studies suggest that nanoscopic fibers with a length of several micrometers have formed by chiral self-organization of Py-E-A gelators. Additionally, live human PBMCs imaging is shown using the Py-E-A fluorophore.

Shifting phenotype and differentiation of CD11bGr.1 immature heterogeneous myeloid derived adjuster cells support inflammation and induce regulators of IL17A in imiquimod induced psoriasis.

Objective And Design: The exact immunological mechanism of widespread chronic inflammatory skin disorder psoriasis has not been fully established. CD11bGr.1 myeloid-derived cells are immature heterogeneous cells with T-cell suppressive property in neoplasia; however, influence of these cells on adaptive immunity is highly contextual; therefore, we dubbed these cells as myeloid-derived adjuster cells (MDAC).

Novel Octahedral Nickel (II) Complex with Flexible Piperazinyl Moiety Exhibits Potent Cytotoxic Effect Along with Anti-Migratory and Anti-Metastatic Effect on Human Cancer Cells.

Synthesis of non-platinum transition metal complexes with N,O donor chelating ligand for application against pathogenesis of cancer with higher efficacy and selectivity is currently an important field of research. We assessed the anti-cancer effect of a mixed ligand Ni(II) complex on human breast and lung cancer cell lines in this investigation. Mononuclear mixed ligand octahedral Ni(II) complex [NiL(NO)(MeOH)] complex (1), with tri-dentate phenol-based ligand 2,4-dichloro-6-((4-methylpiperazin-1-yl) methyl) phenol (HL) along with methanol and nitrate as ancillary ligand was prepared.

Primary small cell neuroendocrine carcinoma of the anterior mediastinum presenting with trepopnea.

We report the case of an elderly man who had visited many physicians with breathlessness and was treated in an outpatient care. The cause of breathlessness was not evaluated, which turned out to be a slow-growing tumour in the mediastinum. Later, we diagnosed it to be a case of neuroendocrine carcinoma arising from the anterior mediastinum.