Soft-tissue changes after maxillomandibular advancement surgery assessed with cone-beam computed tomography.

Introduction: The purpose of this study was to quantify anteroposterior and transverse facial soft-tissue changes with respect to underlying skeletal movements after maxillomandibular advancements by using cone-beam computed tomography.

Methods: Thirty white patients were treated by maxillomandibular advancements after LeFort I osteotomies and bilateral sagittal split osteotomies. The patients were scanned by using cone-beam computed tomography within 1 week before the surgery, within 1 week after the surgery, and a minimum of 8 weeks postsurgery.

Identification of a novel membrane-associated gene product that suppresses toxicity of a TrfA peptide from plasmid RK2 and its relationship to the DnaA host initiation protein.

The toxicity of a peptide derived from the amino-terminal portion of 33-kDa TrfA, one of the initiation proteins encoded by the broad-host-range plasmid RK2, was suppressed by a host protein related to DnaA, the initiation protein of Escherichia coli. The newly identified 28.4-kDa protein, termed a DnaA paralog (Dp) because it is similar to a region of DnaA but likely has a different function in initiation of plasmid RK2 replication, interacts physically with the 33-kDa TrfA initiation protein, including the initiation-active monomeric form.