Preoperative Amiodarone and Primary Graft Dysfunction in Heart Transplantation.

Background: Preoperative amiodarone effects on postorthotopic heart transplant (OHT) outcomes remain controversial.

Objective: The purpose of this study was to determine the effect of cumulative pre-OHT amiodarone exposure on severe primary graft dysfunction (PGD).

Methods: We retrospectively reviewed adult OHT recipients between August 2012 and June 2018.

Clinically important interaction between statin drugs and Clostridium difficile toxin?

Clostridium difficile associated disease (CDAD), a common type of antibiotic associated diarrhea, is increasing in frequency and affecting patients outside of traditional populations. At one time CDAD exclusively occurred in hospitalized patients or frail elderly patients receiving antibiotic therapy. It is now occurring more commonly in younger patients who are relatively healthy and may not be receiving antibiotics.