Horizons in therapy for corneal angiogenesis.

Corneal neovascularization can lead to a devastating disease process that involves the breakdown of the limbal barrier and the formation of blood vessels in the cornea, leading to severe visual impairment. This review discusses the delicate balance between antiangiogenic and angiogenic factors that govern the antiangiogenic privilege of the cornea. Current treatment methods, clinical trials, and future prospects in the management of corneal neovascularization also are discussed.

Comparison of wound strength with and without a hydrogel liquid ocular bandage in human cadaver eyes.

Purpose: To determine whether a hydrogel liquid ocular bandage improves wound strength.

Setting: John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.

CT and orbital ultrasound findings in a case of Castleman disease.

A 53-year-old man with a 2-month history of left periorbital swelling was found to have a large solid intraconal mass on CT scan. Orbital ultrasound showed that the lesion had a cavernous pattern of internal reflectivity. Histopathology revealed hyaline-vascular type Castleman disease (CD).

An anterior chamber toxicity study evaluating Besivance, AzaSite, and Ciprofloxacin.

Purpose: We determined whether Besivance (Bausch & Lomb), AzaSite (Inspire Pharmaceuticals, Inc; both with DuraSite bioadhesive [InSite Vision, Inc]) and ciprofloxacin are toxic inside the anterior chamber.

Design: Randomized, masked, placebo-controlled animal study.

Methods: Twenty New Zealand white rabbits (40 eyes) were randomized to 1 of 4 study groups: Besivance, AzaSite, ciprofloxacin, and balanced salt solution.

A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

Physiological cardiac hypertrophy is associated with mitochondrial adaptations that are characterized by activation of PGC-1alpha and increased fatty acid oxidative (FAO) capacity. It is widely accepted that phosphatidylinositol 3-kinase (PI3K) signaling to Akt1 is required for physiological cardiac growth. However, the signaling pathways that coordinate physiological hypertrophy and metabolic remodeling are incompletely understood.

Two-year follow-up of the Artisan/Verisyse iris-supported phakic intraocular lens for the correction of high myopia.

Purpose: To evaluate the implantation of Artisan/Verisyse phakic intraocular lenses (pIOLs) (Advanced Medical Optics) as an effective and safe method for the correction of high myopia.

Setting: Department of Ophthalmology, John A. Moran Eye Center, University of Utah Medical Center, Salt Lake City, Utah, USA.