Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.

Polycystic ovary syndrome (PCOS) represents the most common cause of anovulatory infertility and affects 5-10% of women of reproductive age. The etiology of PCOS is still unknown. The current study is the first to describe consistent differences in gene expression profiles in human ovaries comparing PCOS patients vs.

Androgen receptor expression in the cervix of androgen-treated female-to-male transsexuals: association with morphology and chain-specific keratin expression.

Long-term androgen treatment of female-to-male transsexuals is associated with morphological changes of the ectocervical epithelium. This study was designed to correlate the histological changes of the ectocervix to modulation of androgen receptor (AR) and keratin expression. We evaluated AR expression by immunohistochemistry using monoclonal antibody F39.

Ovarian morphology in long-term androgen-treated female to male transsexuals. A human model for the study of polycystic ovarian syndrome?

Descriptions of the effect of androgens on ovarian human tissues are exceptional. This opportunity was provided for us by 17 women with transsexualism--female to male transsexuals (TSX)--who had been given androgens for a mean period of 21 months before hystero-salpingo-oophorectomy took place. Twenty-nine ovaries from TSX and 14 control ovaries from 13 regularly cycling women were examined.

Growth of a prolactinoma during pregnancy. Case report and review.

A patient with hyperprolactinaemia and anovulation is described. Ovulation was induced with bromocriptine and the ensuing pregnancy caused rapid deterioration of vision and neurosurgical intervention. The management of hyperprolactinaemic infertility and the complications occurring during pregnancy in these patients are discussed.