Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in parasites.

Unlabelled: Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in () but also in other genes, like . K13 and its compartment neighbors (KICs), including UBP1, are involved in endocytosis of host cell cytosol.

Natural killer cells suppress cancer metastasis by eliminating circulating cancer cells.

Despite significant advances in cancer treatment, the metastatic spread of malignant cells to distant organs remains a major cause of cancer-related deaths. Natural killer (NK) cells play a crucial role in controlling tumor metastasis; however, the dynamics of NK cell-mediated clearance of metastatic tumors are not entirely understood. Herein, we demonstrate the cooperative role of NK and T cells in the surveillance of melanoma metastasis.

Extracellular matrix-natural killer cell interactome: an uncharted territory in health and disease.

Extracellular matrix (ECM) constantly undergoes remodeling to maintain the tissue homeostasis and an impaired ECM remodeling is a hallmark of many diseases, including cancer, infections, and inflammatory disorders. ECM has recently become recognized to regulate the immune response in peripheral tissues. Most immune cells express a diverse array of ECM receptors that, upon engagement by their cognate ECM ligands, can regulate their movement and effector functions.