Publications by authors named "Dominique Vital-Durand"
Multiple cases of sensitization to an antiseptic containing chlorhexidine digluconate/benzalkonium chloride/benzyl alcohol with different profiles of sensitization in adults and children.
Contact Dermatitis
July 2022
Article Synopsis
- An aqueous antiseptic containing chlorhexidine digluconate, benzalkonium chloride, and benzyl alcohol (CBB) is commonly used in France, but its potential to cause allergic contact dermatitis (ACD) has been inadequately studied previously.
- A retrospective study analyzed 102 patients with confirmed ACD to CBB, revealing extensive skin lesions in 63% of cases and a significant delay in diagnosis for 55% of patients.
- Positive patch tests for CBB were found in 93.8% of patients, with benzyl alcohol being the main allergen in adults and chlorhexidine digluconate in children, indicating distinct sensitization profiles between age groups.*
Background: Iodopropynyl butylcarbamate (IPBC) is a broad-spectrum preservative for use in several product types, including cosmetics, in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and the risk of subsequent iodine overdose.
Objectives: To report on concomitant patch test reactions observed with iodine and IPBC in patients sensitized to iodine-containing antiseptics.
Patients: Between 2012 and 2018, seven patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis caused by wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and/or povidone-iodine (PVP-I), which was considered to be relevant for their dermatitis.
Background: Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard.
Objectives: To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium.
Methods: A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint.
Background: The preservative methylisothiazolinone (MI) is used in combination with methylchloroisothiazolinone (MCI), but the MCI/MI mixture has been identified as highly allergenic. MI is considered to be less allergenic, and since the mid-2000s has been widely used alone, but is now clearly identified as a contact allergen. The French Vigilance Network for Dermatology and Allergy of the Study and Research Group on Contact Dermatitis (REVIDAL-GERDA) added MI to its baseline patch testing series in 2010.
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