Automatic vessel attenuation measurement for quality control of contrast-enhanced CT: Validation on the portal vein.

Background: Adequate image enhancement of organs and blood vessels of interest is an important aspect of image quality in contrast-enhanced computed tomography (CT). There is a need for an objective method for evaluation of vessel contrast that can be automatically and systematically applied to large sets of CT exams.

Purpose: The purpose of this work was to develop a method to automatically segment and measure attenuation Hounsfield Unit (HU) in the portal vein (PV) in contrast-enhanced abdomen CT examinations.

Structural insights into the design of reversible fluorescent probes for metallo-β-lactamases NDM-1, VIM-2, and IMP-1.

Metallo-β-lactamases (MBLs) are enzymes that are capable of hydrolyzing most β-lactam antibiotics and all clinically relevant carbapenems. We developed a library of reversible fluorescent turn-on probes that are designed to directly bind to the dizinc active site of these enzymes and can be used to study their dynamic metalation state and enzyme-inhibitor interactions. Structure-function relationships with regards to inhibitory strength and fluorescence turn-on response were evaluated for three representative MBLs.

Assessment of the global noise algorithm for automatic noise measurement in head CT examinations.

Purpose: The global noise (GN) algorithm has been previously introduced as a method for automatic noise measurement in clinical CT images. The accuracy of the GN algorithm has been assessed in abdomen CT examinations, but not in any other body part until now. This work assesses the GN algorithm accuracy in automatic noise measurement in head CT examinations.

Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe.

New Delhi metallo-β-lactamase (NDM) grants resistance to a broad spectrum of β-lactam antibiotics, including last-resort carbapenems, and is emerging as a global antibiotic resistance threat. Limited zinc availability adversely impacts the ability of NDM-1 to provide resistance, but a number of clinical variants have emerged that are more resistant to zinc scarcity (e.g.

Impact of flare-ups on the lives of individuals with low back pain: A qualitative investigation.

Objectives: Investigating flare-ups has become relevant to understanding and managing low back pain (LBP), particularly because there has been a shift in the conceptualization of LBP from acute or chronic to fluctuating or episodic. Available research mainly consists of quantitative studies, which are unable to fully explore the perspectives of individuals with LBP. This study aimed to address this gap by exploring the changes in individual's lives when they experience LBP flare-up.