Comparative effectiveness of nonsurgical interventions in the treatment of patients with knee osteoarthritis: A PRISMA-compliant systematic review and network meta-analysis.

Background: To find out, based on the available recent randomized controlled trials (RCTs), if the nonsurgical interventions commonly used for knee osteoarthritis patients are valid and quantify their efficiency.

Methods: The database of MEDLINE and EMBASE were searched for RCTs evaluating nonsurgical treatment strategies on patients with mild to moderate knee osteoarthritis. A Bayesian random-effects network meta-analysis was performed.

Osteochondral repair combining therapeutics implant with mesenchymal stem cells spheroids.

Functional articular cartilage regeneration remains challenging, and it is essential to restore focal osteochondral defects and prevent secondary osteoarthritis. Combining autologous stem cells with therapeutic medical device, we developed a bi-compartmented implant that could promote both articular cartilage and subchondral bone regeneration. The first compartment based on therapeutic collagen associated with bone morphogenetic protein 2, provides structural support and promotes subchondral bone regeneration.

Computer-assisted total knee arthroplasty: comparative results in a preliminary series of 72 cases.

The aim of this study was to assess the value of navigation in achieving correct positioning of the implants and soft-tissue balance in total knee arthroplasty. We compared the axis alignment achieved in 72 LCS TKA's performed with navigation assistance to a historical cohort of 62 LCS TKA's implanted with the conventional instrumentation. The position of the tibial and femoral implants and the post-operative mechanical axes of the lower limbs were compared in the two series: there was a highly significant improvement in the alignment accuracy in the navigated series (p < 0.