Publications by authors named "Dominique Derse"
Alzheimers Dement
June 2022
Article Synopsis
- - Individuals with Down syndrome (DS) are at a higher risk for developing Alzheimer's disease (AD), and the study explores how increased copies of the APP gene play a role in this connection, termed the APP gene dose hypothesis.
- - The research involved measuring different APP products in various groups, including those with DS, AD-DS, non-demented controls, and sporadic AD cases, revealing significant differences in APP products between these groups.
- - Findings indicate that AD-DS shows higher levels of certain amyloid beta peptides compared to sporadic AD and highlight the need to further investigate the specific APP products contributing to the unique pathology observed in AD-DS.
