Publications by authors named "Dominique C Marterstock"
The value of stimulation-induced seizures for multimodal determination of the epileptogenic zone in preoperative epilepsy diagnostics has not yet been sufficiently investigated. Patients with focal pharmacorefractory epilepsy who underwent invasive electroencephalography with cortical 50 Hz stimulation at the Epilepsy Center Erlangen between 2018 and 2023, had at least one stimulation-induced seizure, underwent resective epilepsy surgery, and had a postoperative follow-up ≥ 1 year were analyzed. 20 patients were included, 11 (55.
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- The study investigates the effectiveness of two anesthesia methods—general anesthesia (GA) and conscious sedation (non-GA)—for patients undergoing endovascular treatment for isolated posterior cerebral artery (PCA) occlusion stroke.
- Researchers analyzed data from the PLATO study focusing on patient outcomes such as the modified Rankin Scale scores after 90 days, as well as successful reperfusion rates and safety measures like intracranial hemorrhage.
- Results show that while both anesthesia methods had similar functional outcomes and safety profiles, GA was associated with significantly higher rates of successful reperfusion during treatment.
Article Synopsis
- The study investigates the effectiveness of endovascular treatment (EVT) versus medical management (MM) in patients with isolated posterior cerebral artery occlusion (iPCAO) during acute ischemic strokes, lacking prior randomized trial evidence.
- Results show that EVT leads to better functional outcomes for patients with more severe stroke symptoms (NIHSS >6), but not for those with milder symptoms (NIHSS ≤6).
- Additionally, while EVT improves outcomes, it is also linked to a higher occurrence of symptomatic intracranial hemorrhages, regardless of initial stroke severity.
Article Synopsis
- A study comparing endovascular therapy (EVT) and medical management (MM) for patients with isolated posterior cerebral artery occlusion found no significant difference in disability outcomes at 90 days.
- EVT showed a greater likelihood of achieving a substantial improvement on the National Institutes of Health Stroke Scale and better overall recovery, despite higher risks of symptomatic intracranial hemorrhage (SICH) and mortality.
- The findings suggest that while EVT may lead to better recovery, it comes with increased risks, indicating the need for careful patient selection in treatment decisions.
Background: Pathogenic variants in SPG11 cause the most common autosomal recessive complicated hereditary spastic paraplegia. Besides the prototypical combination of spastic paraplegia with a thin corpus callosum, obesity has increasingly been reported in this multisystem neurodegenerative disease. However, a detailed analysis of the metabolic state is lacking.
View Article and Find Full Text PDFBackground: SPG11-linked hereditary spastic paraplegia is characterized by multisystem neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive spasticity and weakness. Severe cognitive symptoms are present in the majority of SPG11 patients, but a systematic and multidimensional analysis of the neuropsychological phenotype in a larger cohort is lacking. While thinning of the corpus callosum is a well-known structural hallmark observed in SPG11 patients, the neuroanatomical pattern of cortical degeneration is less understood.
View Article and Find Full Text PDF: Previous studies suggest that brain atrophy can not only be defined by its morphological extent, but also by the cerebral blood flow (CBF) within a certain area of the brain, including white and gray matter. The aim of this study is to investigate known atrophy patterns in different forms of dementia and to compare segmented brain volumetrics and pulsed arterial spin labeling (pASL) data to explore the correlation between brain maps with atrophy and this non-contrast-enhanced brain-perfusion method. : Our study comprised 17 patients with diagnosed cognitive impairment (five Alzheimer's disease = AD, five frontotemporal dementia = FTD, seven mild cognitive impairment = MCI) and 19 healthy control subjects (CO).
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