Low rate of production of apolipoproteins B100 and AI in 2 patients with Anderson disease (chylomicron retention disease).

Objective: Anderson disease is a rare inherited lipid malabsorption syndrome associated with hypocholesterolemia and linked to SAR1B mutations. The aim of this article was to analyze the mechanisms responsible for the low plasma apolipoprotein Apo-B100 and Apo-AI in 2 patients with Anderson disease.

Methods And Results: A primed constant infusion of (13)C-leucine was administered for 14 hours to determine the kinetics of lipoproteins.

Predicting mortality in systemic Wegener's granulomatosis: a survival analysis based on 93 patients.

Objective: To determine predictors of survival of patients with systemic Wegener's granulomatosis (WG).

Methods: We retrospectively studied 93 patients (median age 52 years, male/female ratio 1.7) with systemic WG.

[Clostridium difficile infection in a Department of Internal Medicine. A consecutive series of 45 patients].

Objectives And Methods: A retrospective study of 45 patients with Clostridium difficile infection over a 4-year period in a department of Internal Medicine.

Results: Mean age was 79 years; sex-ratio (F/M)=1.5; 38% of the patients had neurological or severe psychiatric disorders; 20% had a neoplastic disease.