Publications by authors named "Dominika Stencel"
Article Synopsis
- Melanoma is a highly aggressive skin cancer with low treatment effectiveness, prompting research into alternative therapies like tigecycline, a third-generation tetracycline.
- The study found that tigecycline effectively inhibited the growth of both melanotic (COLO 829) and amelanotic (A375) melanoma cells, with more significant effects on the COLO 829 cells, which underwent apoptosis.
- A375 cells showed resistance; instead of apoptosis, they exhibited increased levels of an autophagy marker (LC3A/B) and changes in cell cycle proteins, highlighting the potential for targeted therapy using tigecycline for melanotic melanoma.
