Publications by authors named "Dominika Mihalikova"
Background: Epidemiology links noise to increased risk of metabolic diseases like diabetes and obesity. Translational studies in humans and experimental animals showed that noise causes reactive oxygen species (ROS)-mediated cardiovascular damage. The interaction between noise and diabetes, specifically potential additive adverse effects, remains to be determined.
View Article and Find Full Text PDFAims: We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress.
Methods And Results: NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs.
Effects of aircraft noise cessation on blood pressure, cardio- and cerebrovascular endothelial function, oxidative stress, and inflammation in an experimental animal model.
Sci Total Environ
December 2023
Large epidemiological studies have shown that traffic noise promotes the development of cardiometabolic diseases. It remains to be established how long these adverse effects of noise may persist in response to a noise-off period. We investigated the effects of acute aircraft noise exposure (mean sound level of 72 dB(A) applied for 4d) on oxidative stress and inflammation mediating vascular dysfunction and increased blood pressure in male C57BL/6 J mice.
View Article and Find Full Text PDFArticle Synopsis
- Environmental stressors like traffic noise contribute to a significant loss of healthy life years and require effective prevention strategies to address health impacts, especially related to vascular dysfunction.
- In a study using mice exposed to aircraft noise, various methods of activating α1AMPK—through pharmacological means, exercise, and intermittent fasting—were found to prevent endothelial dysfunction and oxidative stress caused by the noise exposure.
- The findings suggest that activating α1AMPK specifically in endothelial cells can protect against noise-induced vascular damage, highlighting the need for further research to evaluate these interventions in human populations.
Aims: Doxorubicin (DOX) is an important drug for the treatment of various tumor entities. However, the occurrence of heart failure limits its application. This study investigated differential gene expression profiles in the left and right ventricles of DOX treated mice with either preserved or impaired myocardial function.
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