Plasma microRNA-155-5p is increased among patients with chronic kidney disease and nocturnal hypertension.

MicroRNAs play multiple roles in the regulation of blood pressure (BP). Nevertheless, to date, no study has assessed the association between microRNA plasma expression and BP control in chronic kidney disease (CKD) patients. Given this background, we evaluated the plasma expression of miR-155-5p, a translational inhibitor of angiotensin receptor type I, in CKD patients, to determine the association between miR-155-5p level and BP control.

Regulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy.

Multiple factors underlie the pathophysiology of hypertension, involving endothelial dysregulation, vascular smooth muscle dysfunction, increased oxidative stress, sympathetic nervous system activation and altered renin -angiotensin -aldosterone regulatory activity. A class of non-coding RNA called microRNA, consisting of 17-25 nucleotides, exert regulatory function over these processes. This paper summarizes the currently available data from preclinical and clinical studies on miRNA in the development of hypertension as well as the impact of anti-hypertensive treatment on their plasma expression.

Depression in relation to biochemical parameters and age in women with polycystic ovary syndrome.

Objective: The phenotype of women with PCOS changes with age. The study was aimed to address whether changes in biochemical parameters associated with age of the patients correlate with depression severity measured with the use of screening tools.

Study Design: This was a single center observational study.