Secondary metabolite profiles and anti-SARS-CoV-2 activity of ethanolic extracts from nine genotypes of Cannabis sativa L.

This study deals with the comprehensive phytochemical composition and antiviral activity against SARS-CoV-2 of acidic (non-decarboxylated) and neutral (decarboxylated) ethanolic extracts from seven high-cannabidiol (CBD) and two high-Δ-tetrahydrocannabinol (Δ-THC) Cannabis sativa L. genotypes. Their secondary metabolite profiles, phytocannabinoid, terpenoid, and phenolic, were determined by LC-UV, GC-MS, and LC-MS/MS analyses, respectively.

Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing.

Although medical cannabis was legalized in Czechia in 2013 and its use in topical treatments of skin disorders is now allowed, galenic formulations prepared from medical cannabis have not been widely implemented in the Czech healthcare system. One of the main reasons is the lack of a straightforward standardized protocol for their preparation. Cannabinoids, e.

Cannabis-derived products antagonize platinum drugs by altered cellular transport.

Cannabinoids, a class of compounds derived from Cannabis sativa L., have recently become more widely accessible for public consumption in the form of diverse cannabis products, in parallel with weakening the measures that so far restricted their availability. The US Food and Drug Administration has approved several cannabis-derived drugs for management of various diseases as well as chemotherapy-induced nausea and vomiting.

Investigation of the Effect of the Auxin Antagonist PEO-IAA on Cannabinoid Gene Expression and Content in L. Plants under In Vitro Conditions.

The in vitro shoot propagation of L. is an emerging research area for large-scale plant material production. However, how in vitro conditions influence the genetic stability of maintained material, as well as whether changes in the concentration and composition of secondary metabolites can be expected are aspects that need to be better understood.

Cis-Δ-tetrahydrocannabinolic acid occurrence in Cannabis sativa L.

Cannabidiolic acid (CBDA) and trans-Δ-tetrahydrocannabinolic acid (trans-Δ-THCA) are known to be the major phytocannabinoids in Cannabis sativa L., along with their decarboxylated derivatives cannabidiol (CBD) and trans-Δ-tetrahydrocannabinol (trans-Δ-THC). The cis isomer of Δ-THC has been recently identified, characterized and quantified in several Cannabis sativa varieties, which had been heated (decarboxylated) before the analysis.

Influence of Technological Maturity on the Secondary Metabolites of Hemp Concentrate ( L.).

During the last decade, the popularity of hemp products has been rising rapidly. Products containing cannabidiol (CBD) are of predominant interest. Traditional hemp products are frequently enriched by CBD due to their potential therapeutic effects.

Influence of Extraction Solvent on the Phenolic Profile and Bioactivity of Two Species.

The phenolic composition, as well as the antioxidant and antimicrobial activities of two poorly investigated species, Waldst. and the endemic Vis., were studied.