Syndromic immunodeficiencies: a pediatrician's perspective on selected diseases.

Background: Syndromic immunodeficiencies are a genetically and pathophysiologically heterogeneous group of inborn errors of immunity. These are characterized by multiple extra immune clinical symptoms and a wide range of immunological phenotypes with increased susceptibility to infections, autoimmune phenomena, immune dysregulation, organ-specific pathology, and malignancy.

Objective: To increase the pediatricians' awareness of this multifaceted group of primary immunodeficiencies in children.