Publications by authors named "Dominika Deborska Materkowska"
Article Synopsis
- Many kidney transplant patients are classified as having no rejection after biopsy, but some may actually have undetected rejection activities.
- A study of over 5,000 biopsies found that more than half were marked as no rejection, yet many showed signs of subthreshold T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR).
- Patients with these hidden rejection activities are at increased risk of future graft issues, as higher levels of TCMR and ABMR correlate with worse kidney function and higher chances of rejection in subsequent biopsies.
Article Synopsis
- Protocol biopsies can identify early subclinical issues in kidney transplant patients which may lead to graft dysfunction, but their routine use varies across transplant centers.* -
- In a study of 61 patients, those with mild inflammatory lesions and BK virus nephropathy showed improved long-term outcomes after treatment adjustments following protocol biopsies.* -
- Overall, protocol biopsies appear valuable for early detection of problems in transplants, helping to maintain stable kidney function and potentially preventing graft failure.*
Potential utility of urinary chemokine CCL2 to creatinine ratio in prognosis of 5-year graft failure and mortality post 1-year protocol biopsy in kidney transplant recipients.
Michal Gniewkiewicz Jolanta Gozdowska Dominika Deborska-Materkowska Katarzyna Czerwinska Agnieszka Perkowska-Ptasinska
Immun Inflamm Dis
June 2023
Article Synopsis
- Chemokines are small proteins involved in processes like inflammation and are being studied for their role in transplant medicine, specifically in predicting outcomes after renal transplants.
- * This study focused on urinary chemokines CCL2 and CXCL10 to assess their effectiveness in forecasting 5-year graft failure and mortality in kidney transplant patients after a one-year biopsy.
- * Results indicated that higher levels of urinary CCL2 correlated with increased risk of graft failure and death, suggesting that CCL2 could serve as a valuable biomarker in the context of personalized medicine.
Antiviral prophylaxis, male sex, and killer immunoglobulin-like receptor KIR2DL3 as markers for stratifying the risk of BK polyomavirus-associated nephropathy in kidney transplant recipients.
Dominika Dęborska-Materkowska Agnieszka Perkowska-Ptasinska Anna Sadowska-Jakubowicz Joanna Pazik Marta Serwańska-Świętek
Pol Arch Intern Med
January 2023
Article Synopsis
- The study focuses on the risk of polyomavirus-associated nephropathy (PyVAN) in kidney transplant recipients, highlighting a concerning incidence rate and potential graft loss.
- It examines the link between patients’ killer-cell immunoglobulin-like receptor (KIR) genotypes and the development of PyVAN, alongside other risk factors like acute rejection and lack of antiviral measures.
- Results indicate that certain genetic factors, particularly the presence of KIR2DL3, along with factors like male sex and past acute rejection episodes, significantly increase the likelihood of developing PyVAN after transplantation.
Article Synopsis
- COVID-19, primarily known for affecting the lungs, can also cause various extrapulmonary symptoms that impact other organs and systems in the body.
- The article discusses three cases: a 29-year-old woman with new-onset diabetes, a 34-year-old man with multiple painful conditions likely due to coagulopathy, and a 68-year-old kidney donor with skin lesions and recurrent fever.
- The findings highlight the importance of recognizing these diverse symptoms for proper diagnosis and treatment, emphasizing that SARS-CoV-2 can lead to a wide range of health issues beyond respiratory problems.
Article Synopsis
- The COVID-19 pandemic, caused by the SARS-CoV-2 virus, elicits a strong immune response that can lead to severe systemic inflammation and cytokine release syndrome in critical cases.
- The evolving SARS-CoV-2 variants challenge the immunity developed through previous infections or vaccinations, making immune response understanding crucial for managing the disease.
- This paper reviews the mechanisms of immune responses to various COVID-19 vaccines and highlights specific considerations for different patient populations with altered immune systems, along with tools for studying immune responses to the virus.*
Article Synopsis
- The COVID-19 pandemic, starting in December 2019, spurred a surge in research focused on the virus and potential treatments, particularly concerning its effects on various populations.
- Solid organ transplant (SOT) recipients, who live with long-term immunosuppression, are particularly vulnerable to severe COVID-19 infections and face a higher risk of mortality.
- The study discusses the balance between the harmful effects of hyperinflammation during severe COVID-19 and the weakened antiviral T cell responses in SOT patients, exploring current immunology research and potential vaccination and treatment strategies for this group.
Article Synopsis
- * The Banff Working Group introduced a new classification for PyVAN based on viral load and interstitial fibrosis levels to better understand and categorize the condition.
- * In a study of 124 kidney transplant patients, the new classification did not effectively predict risk for graft failure, with class 3 showing the worst outcomes but no significant differences between classes 1 and 2; additional factors like post-transplant timing and inflammation also played a role in graft failure.
Background: Despite its established association with chronic kidney disease (CKD) the role of myosin-9 (MYH9) gene variation on transplanted kidney function remains unknown. This study aimed at evaluating the effect of donor MYH9 nephrogenic variants on renal allograft function within the first post transplantation year.
Methods: In the longitudinal kidney transplant study 207 deceased donors were genotyped for previously known risk MYH9 single nucleotide polymorphisms (SNPs).
Article Synopsis
- * This study investigated the levels of microRNA-21-5p (miR-21) in the urine of 31 kidney transplant patients to see if it correlates with IFTA and overall kidney function, using real-time quantitative PCR to analyze samples.
- * Results showed that higher miR-21 levels were associated with more severe IFTA and correlated significantly with kidney function markers, suggesting miR-21 could serve as a promising non-invasive biomarker for monitoring kidney transplant health.
Urinary levels of CCL2 and CXCL10 chemokines as potential biomarkers of ongoing pathological processes in kidney allograft: an association with BK virus nephropathy.
Michał S Gniewkiewicz Magdalena Czerwińska Jolanta Gozdowska Katarzyna Czerwińska Anna Sadowska Dominika Dęborska-Materkowska
Pol Arch Intern Med
September 2019
Article Synopsis
- Early identification of high-risk kidney transplant recipients can improve immunosuppressive therapy and patient outcomes.
- This study assessed whether measuring urinary CCL2 and CXCL10 chemokines could serve as a noninvasive tool to detect ongoing issues in kidney transplants.
- Findings suggest that the CCL2 to creatinine ratio can predict BK virus nephropathy, while the CXCL10 ratio did not show the same predictive capability, indicating the need for more research on these markers.
Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.
Dominika Deborska-Materkowska Agnieszka Perkowska-Ptasinska Anna Sadowska-Jakubowicz Jolanta Gozdowska Michał Ciszek
Int J Mol Sci
January 2019
Article Synopsis
- Cytomegalovirus (CMV) infection poses significant risks to kidney transplant recipients, leading to serious complications and potential mortality.
- Research involving 138 transplant recipients revealed that specific KIR genes and their ligands, along with factors like kidney function and timing of antiviral treatment, influence the likelihood of developing posttransplant CMV infection.
- The study highlights the importance of both genetic and environmental factors in determining susceptibility to CMV infection after kidney transplantation, emphasizing the role of KIR/HLA genotype in immunity against the virus.
Article Synopsis
- A study was conducted to assess the risk of late cytomegalovirus (CMV) infection in kidney transplant recipients after stopping prophylactic antiviral treatment.
- The research involved 86 patients divided into groups based on their pretransplant CMV antibody status, with viral T-cell responses measured using the QF-CMV assay.
- Results showed that 24% of patients developed CMV viremia within a year of transplantation, with a significant difference in infection rates based on the T-cell response and the presence of hypogammaglobulinemia.
Article Synopsis
- * Aging leads to a natural decline in kidney function, increasing vulnerability to conditions like hypertension and diabetes, and complicating the diagnosis and treatment of kidney diseases in older adults.
- * Elderly patients with CKD often present with multiple health issues and unique medication metabolism, necessitating personalized treatment approaches that consider their complex health profiles.
Article Synopsis
- This report is the first comprehensive analysis of kidney diseases in Poland, analyzing data from 9,394 renal biopsies conducted between 2009 and 2014.
- The findings indicate a steady increase in the number of renal biopsies per million people, from 36 in 2009 to 44 in 2014, with significant regional differences across provinces in Poland.
- The most prevalent kidney diseases identified were immunoglobulin A nephropathy (20%) and focal segmental glomerulosclerosis (15%) in adults, while in children, minimal change disease (22%) was most common, highlighting diverse glomerulopathies based on patient age and condition type.
Article Synopsis
- Longer life expectancy leads to more cases of kidney disease in the elderly, and this study analyzes kidney biopsy findings in patients aged 65 and older compared to younger adults.
- The research included 352 elderly patients and 2,214 younger patients, revealing that nephrotic range proteinuria was the main reason for biopsies in the elderly, with specific kidney conditions like membranous glomerulonephritis being prevalent.
- It was found that common age-related kidney issues (like hypertensive damage) were less frequent, with many elderly patients showing no diabetic changes despite having diabetes, indicating distinct patterns of kidney disease in older individuals.
Severe cytomegalovirus infection in a second kidney transplant recipient treated with ganciclovir, leflunomide, and immunoglobulins, with complications including seizures, acute HCV infection, drug-induced pancytopenia, diabetes, cholangitis, and multi-organ failure with fatal outcome: a case report.
Dorota Miszewska-Szyszkowska Natalia Mikołajczyk Ewa Komuda-Leszek Renata Wieczorek-Godlewska Robert Świder Dominika Dęborska-Materkowska
Ann Transplant
March 2015
Article Synopsis
- - Cytomegaly is a major infectious risk for organ transplant recipients, impacting both the success of the transplant and overall patient survival.
- - A 32-year-old woman faced severe complications after her second kidney transplant, struggling with recurrent CMV infection despite multiple treatment strategies, including ganciclovir and combination therapies.
- - Ultimately, her condition deteriorated due to multiple organ failure after a sequence of complications, showcasing the challenges in managing CMV infections in transplant patients.
Human herpesvirus 6 (HHV-6) is a lymphotropic herpesvirus of emerging clinical significance in immunocompromised patients. Little is known about clinical impact and relevance of HHV-6 variant A infection in renal transplant recipients. We describe the case of a 44-year-old woman who underwent second allogenic kidney transplantation (Tx).
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