Estrogen Receptor Genes, Cognitive Decline, and Alzheimer Disease.

Background And Objectives: Lifetime risk of Alzheimer disease (AD) dementia is twofold higher in women compared with men, and low estrogen levels in postmenopause have been suggested as a possible contributor. We examined 3 (, , and ) variants in association with AD traits as an indirect method to test the association between estrogen and AD in women. Although the study focus was on women, in a comparison, we separately examined molecular variants in men.