Publications by authors named "Dominik John"

Background: A significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as smooth-shaped dense masses and require the recalling of women for a breast ultrasound to obtain complementary imaging information. They can be identified safely by ultrasound with no need for further assessment or treatment.

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  • GbPC-CT is gaining popularity for its ability to enhance soft-tissue contrast in imaging, but it struggles with resolution issues, especially at low doses commonly used in clinical settings.
  • The study introduces a self-supervised deep learning model called Noise2Inverse, which helps enhance image quality while reducing the required radiation dose.
  • The results show that Noise2Inverse outperforms traditional denoising methods, indicating that deep learning can improve the resolution of gbPC-CT images, making it a more viable option for medical applications.
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  • Monitoring freezing in tissue is essential during cryoablation, a cancer treatment that freezes tumors to destroy them without harming nearby healthy tissue.
  • A common way to check the freezing is through CT scans, but it's hard to see the difference between frozen and unfrozen tissue.
  • Researchers found that using X-ray dark-field imaging can make it much easier to see frozen areas, which may improve how doctors monitor the treatment.
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Purpose: To compare the performance of the dominant and nondominant hand during fundamental arthroscopic simulator training.

Methods: Surgical trainees who participated in a 2-day simulator training course between 2021 and 2023 were classified, according to their arthroscopic experience in beginners and competents. Only right-handed individuals with complete data sets were included in the study.

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Purpose: It is reasonable to question whether the case volume is a suitable proxy for the manual competence of an arthroscopic surgeon. The aim of this study was to evaluate the correlation between the number of arthroscopies previously performed and the arthroscopic skills acquired using a standardized simulator test.

Methods: A total of 97 resident and early orthopaedic surgeons who participated in arthroscopic simulator training courses were divided into five groups based on their self-reported number of arthroscopic surgeries: (1) none, (2) < 10, (3) 10 to 19, (4) 20 to 39 and (5) 40 to 100.

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New communication technologies allow patients to communicate with their physicians from anywhere using computer or smartphone. Adding video to the mere phone call optimizes the personal contact between patient and physicians regardless of distance. Legal and reimbursements requirements must be taken into account, especially only certified software products must be used.

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Purpose: The purpose of this study was to identify modifiable factors associated with research activity among residents working in orthopedic surgery and traumatology.

Methods: Residents at 796 university-affiliated hospitals in Austria, Germany, and Switzerland were invited to participate. The online survey consisted of questions that ascertained 13 modifiable and 17 non-modifiable factors associated with the residents' current research activities.

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Background: Bioabsorbable suture anchors have been associated with bone-derived complications, such as osteolysis and cyst formation, after rotator cuff repair. The purpose of this study was to assess the osseous degradation process of the novel biocomposite suture anchor material polylactic-co-glycolic acid (PLGA)/beta-tricalcium phosphate (ß-TCP)/calcium sulfate (CS) after arthroscopic single-row rotator cuff repair. The focus of interest was the appearance of osteolysis and the rate of total resorption of the implants after 21 months.

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Tissue macrophages and inflammatory neutrophils represent important cells of the innate immune system responsible for various important tasks, i.e., elimination of pathogens and/or granuloma formation.

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Using cutaneous leishmaniasis of mice, the existence of so-called T helper (Th) cells type 1 and type 2 had been identified more than 20 years ago. Nowadays, it is well accepted that additional T cell populations as well as B cell-mediated immunity is required for immunity against Leishmania major. Finally, using inbred mouse strains, the relevance of genetical factors that influence anti-pathogen immunity as well as elements of the skin-immune system have been identified.

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Migratory skin dendritic cells (DCs) are thought to play an important role in priming T cell immune responses against Leishmania major, but DC subtypes responsible for the induction of protective immunity against this pathogen are still controversial. In this study, we analyzed the role of Langerin(+) skin-derived DCs in the Leishmania model using inducible in vivo cell ablation. After physiologically relevant low-dose infection with L.

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