Evaluation of invasive breast cancer samples using a 12-chemokine gene expression score: correlation with clinical outcomes.

Background: A unique 12-chemokine gene expression score (CS) accurately predicted the presence of tumor-localized, ectopic lymph node-like structures (TL-ELNs) and improved overall survival (OS) in primary colorectal cancer and metastatic melanoma. We analyzed the correlation between CS, clinicopathological variables, molecular data, and 366 survival in Moffitt Cancer Center's Total Cancer Care (TCC) patients with non-metastatic breast cancer.

Methods: Affymetrix gene expression profiles were used to interrogate the CS by the principal component method.