CD8α Dendritic Cells Dictate Leukemia-Specific CD8 T Cell Fates.

APCs are essential for the orchestration of antitumor T cell responses. Batf3-lineage CD8α and CD103 dendritic cells (DCs), in particular, are required for the spontaneous initiation of CD8 T cell priming against solid tumors. In contrast, little is known about the APCs that regulate CD8 T cell responses against hematological malignancies.

Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia.

Exposure of cancer cells to particular chemotherapeutic agents or γ-irradiation induces a form of cell death that stimulates an immune response in mice. This "immunogenic cell death" requires calreticulin (CRT) translocation to the plasma membrane, which has been shown to promote cancer cell phagocytosis. However, it remains unclear whether the effect of CRT on cancer cell phagocytosis is alone sufficient to affect tumor immunity.

PD-1 regulates extrathymic regulatory T-cell differentiation.

Treg cells and the programed death-1/programed death ligand-1 (PD-1/PD-L1) pathway are both critical for maintaining peripheral tolerance to self-Ags. A significant subset of Treg cells constitutively expresses PD-1, which prompted an investigation into the role of PD-1/PD-L1 interactions in Treg-cell development, function, and induction in vivo. The phenotype and abundance of Treg cells was not significantly altered in PD-1-deficient mice.