Examining community-level social vulnerability and emergency department use for people living with sickle cell disease in Michigan.

This study examined associations between emergency department (ED) visits and social vulnerability index (SVI) among Michigan's population with sickle cell disease (SCD) using data from the Michigan Sickle Cell Data Collection program (n = 3658 in 2018). SVI was higher among census tracts where people with SCD resided (mean SVI = 0.67; SD = 0.

Calculation of livestock biomass and value by province in Indonesia: Key information to support policymaking.

Accurate estimations of the biomass and value of livestock in Indonesia are of great use in supporting investment decisions by the public and private sector and as a basis for estimating the losses due to animal disease. Biomass and the partial direct use value for key livestock species (cattle, buffalo, sheep, goats, pigs, chickens) for all provinces of Indonesia were derived from secondary data using a novel spreadsheet-based model. Using beef cattle as an example, we also explored the use of a herd dynamics model to validate base data on populations and productivity used to generate biomass values, and these were found to be generally robust.

Beyond Numbers: Determining the Socioeconomic and Livelihood Impacts of African Swine Fever and Its Control in the Philippines.

The impacts of African Swine Fever (ASF) have most frequently been described quantitatively though it is increasingly acknowledged these impacts extend well beyond numbers. During 2020, a multidisciplinary team of researchers developed a framework for Socioeconomic and Livelihood Impact Assessment (SELIA) of livestock diseases in smallholder communities. Two key innovations within this SELIA framework are the integration of sustainable livelihoods concepts to capture rich information beyond financial impacts, and the inclusion of stakeholders across the value chain, beyond farmers.

Telehealth Use Before and During the COVID-19 Pandemic Among Children with Sickle Cell Anemia.

Sickle cell anemia (SCA) is a genetic condition that predominantly affects minority populations in the United States. A lack of access to care is strongly associated with poor outcomes and quality of care among children and adolescents with SCA. The use of telehealth, which has rapidly expanded during the COVID-19 pandemic, has been shown to improve access to care for many conditions.

Investigating the Socio-Economic and Livelihoods Impacts of African Swine Fever in Timor-Leste: An Application of Spatial Group Model Building.

Small-scale pig farming is highly important to the economic and social status of households in Timor-Leste. The presence of an African Swine Fever (ASF) outbreak in Timor-Leste was confirmed in 2019, a major concern given that around 70% of agricultural households practice pig farming. This research used a virtual spatial group model building process to construct a concept model to better understand the main feedback loops that determine the socio-economic and livelihood impacts of the ASF outbreak.

Influenza immunization coverage of children with sickle cell disease.

Objectives: To assess receipt of annual flu immunization among children living with sickle cell disease (SCD).

Methods: Receipt of flu immunization (2014-2019) by SCD status was assessed among all Michigan children <18 years of age using the statewide immunization registry. Logistic regression was used to estimate the odds of annual flu immunization by SCD status and age.

Necessity, Entailment, Shared Agonism.

This short paper offers a series of responses to Jochem Zwier and Timothy Barker's comments on my extended paper 'Taking Exception: Philosophy of Technology as a Multidimensional Problem Space.' Part one responds to questions concerning the modality of the renewed understanding of the theme of the transcendental that was argued for in my initial paper: I argue for the deep of such a move, against any sense that it is Part two takes this consideration of modality further, considering the that a renewal of the theme of the transcendental stands to offer philosophy of technology today. I argue that the contingency of our contemporary sense of the transcendental can be precisely what makes it valuable.

Primary Immunization Series Coverage of Children With Sickle Cell Disease.

Introduction: Children with sickle cell disease are at increased risk of serious infections, many of which can be prevented by receipt of recommended immunizations. Study objectives were to (1) assess the primary immunization series coverage among children with sickle cell disease and (2) compare the coverage with that of those without sickle cell disease.

Methods: The Michigan Care Improvement Registry was used to obtain primary immunization series doses and sickle cell disease status for all eligible children in Michigan born in 2001-2016 (analysis was conducted in 2019).

Counting the cost: The potential impact of African Swine Fever on smallholders in Timor-Leste.

In September 2019, Timor-Leste, where pigs are kept by more than 70 percent of households, became the eleventh Asian country to report African Swine Fever (ASF). Drawing on our recent, as-yet unpublished research we show that while national pork consumption is low, pigs hold tremendous monetary value for smallholders within the economy of ceremonies. Given the sums of money paid for live pigs, the value of the national pig herd is around USD160 million - more than USD1000 per pig keeping household.

Health Disparities and the Global Landscape of Lymphoma Care Today.

Lymphoma encompass a wide variety of distinct disease entities, including, but not limited to, subtypes of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). In the last 3 decades, therapeutic advancements have resulted in substantial improvements in lymphoma outcome. In most high-income regions, HL is a largely curable disease and for patients with two frequent subtypes of NHL, diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL), survival has dramatically improved with the incorporation of rituximab as a standard treatment approach.

Leucine-enriched protein feeding does not impair exercise-induced free fatty acid availability and lipid oxidation: beneficial implications for training in carbohydrate-restricted states.

Given that the enhanced oxidative adaptations observed when training in carbohydrate (CHO)-restricted states is potentially regulated through free fatty acid (FFA)-mediated signalling and that leucine-rich protein elevates muscle protein synthesis, the present study aimed to test the hypothesis that leucine-enriched protein feeding enhances circulating leucine concentration but does not impair FFA availability or whole body lipid oxidation during exercise. Nine males cycled for 2 h at 70% VO2peak when fasted (PLACEBO) or having consumed a whey protein solution (WHEY) or a leucine-enriched whey protein gel (GEL), administered as 22 g 1 h pre-exercise, 11 g/h during and 22 g 30 min post-exercise. Total leucine administration was 14.

Information theory and signal transduction systems: from molecular information processing to network inference.

Sensing and responding to the environment are two essential functions that all biological organisms need to master for survival and successful reproduction. Developmental processes are marshalled by a diverse set of signalling and control systems, ranging from systems with simple chemical inputs and outputs to complex molecular and cellular networks with non-linear dynamics. Information theory provides a powerful and convenient framework in which such systems can be studied; but it also provides the means to reconstruct the structure and dynamics of molecular interaction networks underlying physiological and developmental processes.

Reported dose as a measure of drug exposure after paracetamol overdose in children.

The decision to administer antidote after paracetamol overdose is based on the extent of drug exposure, and this often relies on the reported dose. Few data exist concerning the validity of this approach in children. The present observational study sought to examine the relationship between the reported dose and paracetamol concentrations in patients aged ≤18 years admitted to York Hospital between October 2008 and November 2010 inclusive.

Congenital cytomegalovirus infection associated with development of neonatal emphysematous lung disease.

A 26-week-gestation infant developed cystic lung changes which required lobar resection at 6 weeks of age. Lung histology showed cytomegalovirus (CMV) inclusion bodies. The authors present the radiology and histology images of this case and review the literature regarding congenital CMV infection and cystic lung disease.

Abdominal pain and hyperamylasaemia--not always pancreatitis.

A raised serum amylase concentration, at least four times the upper limit of normal (ULN), is used to support the diagnosis of acute pancreatitis in a patient presenting with abdominal pain. The authors report a case of toxic shock syndrome complicated by a raised serum amylase concentration that peaked at 50 times the ULN in a patient with recurrent abdominal pain. The commonest cause of hyperamylasaemia is pancreatic; however, further investigation of serum lipase and amylase isoenzyme studies found this to be of salivary origin and attributable to soft tissue inflammation of the salivary gland.

Trimethylsilylated allyl complexes of nickel. The stabilized bis(pi-allyl)nickel complex [eta3-1,3-(SiMe3)2C3H3]2Ni and its mono(pi-allyl)NiX (X=Br, I) derivatives.

Reaction of 2 equiv of K[1,3-(SiMe3)2C3H3] with NiBr2(dme) in THF at -78 degrees C produces the orange pi-allyl complex [1,3-(SiMe3)2C3H3]2Ni (1). Unlike the pyrophoric (C3H5)2Ni, the trimethylsilylated derivative only slowly decomposes in air (from hours to days). Both eclipsed (1a) and staggered (1b) conformations are found in solution; the eclipsed form irreversibly converts to the thermodynamically more stable staggered conformation when heated above 85 degrees C.

Orthotopic liver transplantation for acute liver failure secondary to autoimmune hepatitis in a child with autoimmune polyglandular syndrome type 1.

Autoimmune polyglandular syndrome type 1 (APS-1) is an autosomal-recessive condition characterized by hypoparathyroidism, autoimmune Addison's disease, and chronic mucocutaneous candidiasis. Autoimmune hepatitis develops in 10-20% of affected patients and has a variable course ranging from asymptomatic chronic liver disease to lethal fulminant hepatic failure. Liver transplantation has been documented previously in only two patients.